What is NIPT?
Noninvasive prenatal testing (NIPT), sometimes called noninvasive prenatal screening test (NIPS), is a method of determining the risk that the fetus will be born with specific genetic abnormalities.
It has been a little over two years since noninvasive prenatal testing (NIPT) was introduced as part of prenatal care to screen high-risk patients for fetal aneuploidy.
NIPT (Noninvasive prenatal testing) screens for Down syndrome (trisomy 21), Edwards syndrome (trisomy 18), and Patau syndrome (trisomy 13). Sex chromosome abnormalities, such as Turner syndrome (45, X) and Klinefelter syndrome (47, XXY), can also be detected.
What is the cost of NIPT Test?
The cost of NIPT Test ranges from Rs.12000 to Rs.13000.
How many days will it take for results to come?
Our tests are done twice so as to ensure the accuracy in excess of 99.99%. The reports will take 8-10 working days and they will be sent to your email address.
How to book an appointment over the phone?
You can reach us on any of the below-listed phone numbers and get your appointment slot booked.
- NIPT Mumbai Call: (022)48937160
- NIPT Kolkata Call: (033)40836441
- NIPT Chennai Call: (044)48137110
- NIPT Bangalore Call: (080)45684079
- NIPT Hyderabad Call: (040)49171772
- NIPT Ahmedabad Call: (079)49107674
- NIPT Pune Call: (020)71171786
- NIPT Indore Call: (0731)4853888
- NIPT Kochi Call: (0495)4269777
- NIPT Delhi Call: (011)40849842
What is the difference between Illumina and Ion torrent?
Illumina amplifies individual library molecules on a solid surface to form polonies Ion Torrent uses emulsion PCR on beads. Illumina uses reversible terminated nucleotides delivered as pools of all four. Detection is via imaging. Older instruments used a distinct fluorophore on each nucleotide.
Ion Torrent uses natural nucleotides presented as pure sets of individual nucleotides. Detection is via the H+ Ion generated during nucleotide incorporation, using electronic sensors in each well of the sequencing plate.
Down Syndrome (Trisomy 21):
Down syndrome, or trisomy 21, is a genetic condition. It is a genetic condition that occurs when there is an extra copy of a specific chromosome: chromosome 21.
Down syndrome is not an illness. The term describes the features resulting from this change. The extra chromosome can affect a person’s physical features, intellect, and overall development.
Edwards Syndrome (Trisomy 18):
Trisomy 18, also known as Edwards syndrome, is the second most common trisomy behind trisomy 21 Down syndrome ). It occurs in 1 in 5,000 live births and it is caused by the presence of an extra chromosome 18 and similar to Down syndrome.
Babies born with trisomy 18 have distinct clinical features, including developmental delay and craniofacial, limb, heart , and kidney abnormalities. Half of all babies born with Edwards syndrome die within the first week.
Patau Syndrome (Trisomy 13):
Trisomy 13 or Patau Syndrome is a genetic disorder that your baby gets when she has an extra 13th chromosome. In other words, she has three copies of her chromosome 13 when she should have just two.
It happens when cells divide abnormally during reproduction and create extra genetic material on chromosome 13. The additional chromosome can come from either the egg or the sperm.
Sex Chromosome Abnormalities:
Turner syndrome, a condition that affects only females, results when one of the X chromosomes (sex chromosomes) is missing or partially missing. Turner syndrome may be diagnosed before birth (prenatally), during infancy or in early childhood.
Klinefelter syndrome is a chromosomal condition in boys and men that can affect physical and intellectual development. Most commonly, affected individuals are taller than average are unable to father biological children.
Who should opt for this test?
All pregnant women who need insight into their baby’s development can avail of the test, regardless of their age. Medical societies today support the use of NIPT as the first line of screening test for all pregnancies, irrespective of the risk. For physicians, it is crucial to recommend this test for pregnancies where:
- The woman is above 35 years of age.
- A high risk for abnormality is found in serum screening.
- Specific abnormalities on ultrasound are identified.
How does the NIPT Test work?
NIPT (Noninvasive Prenatal Testing) analyzes cell-free DNA from a maternal blood sample (a mixture of fetal and maternal DNA) to screen for common chromosomal conditions including trisomy 21 (Down syndrome), trisomy 18 (Edwards syndrome), and trisomy 13 (Patau syndrome).
Initial screening with noninvasive prenatal testing can help to avoid this potentially unnecessary and invasive testing. There is no risk to mother or baby, and NIPT provides the earliest testing available.
Small amounts of a baby’s DNA passes into the bloodstream of the mother during pregnancy. New technology allows us to analyze this DNA directly from the mother’s blood and screen for chromosomal abnormalities.
Does the NIPT Test for Gender?
The Pre-Conception and Pre-Natal Diagnostic Techniques (Prohibition of Sex Selection) Act, 2003, commonly called PC-PNDT Act, makes it illegal to determine the sex of the unborn child or even use sex-selection technologies.
How accurate is NIPT?
NIPT is more accurate than traditional first-trimester screening. That means there will be much less chance your doctor would recommend follow-up testing such as amniocentesis. It is accurate up to 99.99%.
Interpreting the results:
A positive result means that it is likely that your baby will have one of the tested conditions. A negative result means that it is unlikely your baby will have Down syndrome or another chromosomal defect analyzed by this noninvasive prenatal test.
What to do if the result is positive?
If the outcome of your noninvasive prenatal test is positive, you should consult with your doctor and plan another diagnostic testing to confirm this result or exclude diagnosis related to that result.
How can I locate a collection centre near me?
DNA Labs India has more than 3000 collection centres for NIPT Test. We provide home collection for every test booked online. Click here to see the list of our test collection centres.