What is NIPT?
Non-invasive prenatal testing (NIPT) is a new method of testing for common chromosomal abnormalities that can occur in a developing baby.
These chromosome abnormalities can have profound consequences to the life and health of your child and it is important to find out as soon as possible. NIPT Test helps in early detection of these abnormalities as early as from 9th week of pregnancy.
What does NIPT detect?
NIPT Test detect for the 3 most common chromosomal disorders:
- Trisomy 21 (Down syndrome)
- Trisomy 18 (Edwards syndrome)
- Trisomy 13 (Patau syndrome)
What is the cost of NIPT Test in India?
NIPT Test cost is in range of 11000 to 13000 INR at DNA labs India. DNA labs India has sample collection facilities in the cities listed below for NIPT Test
The NIPT Test sample is a simple blood draw test and sample can be collected from Mumbai, Delhi, Bangalore, Hyderabad, Ahmedabad, Chennai, Kolkata, Surat, Pune, Jaipur, Visakhapatnam, Kanpur, Nagpur, Lucknow, Thane, Bhopal, Indore, Pimpri-Chinchwad, Patna, Vadodara, Ghaziabad, Ludhiana, Agra, Nashik, Faridabad, Meerut, Rajkot, Kalyan-Dombivli, Vasai-Virar, Varanasi, Srinagar, Aurangabad, Dhanbad, Amritsar, Navi, Mumbai, Allahabad, Howrah, Ranchi, Gwalior, Jabalpur, Coimbatore, Vijayawada, Jodhpur, Madurai, Raipur, Chandigarh, Guntur, Guwahati, Solapur, Hubli–Dharwad, Mysore, Tiruchirappalli, Bareilly, Moradabad, Tiruppur, Gurgaon, Aligarh, Jalandhar, Bhubaneswar, Salem, Mira-Bhayandar, Warangal, Jalgaon, Kota, Bhiwandi, Saharanpur, Gorakhpur, Bikaner, Amravati, Noida, Jamshedpur, Bhilai, Cuttack, Firozabad, Kochi, Nellore, Bhavnagar, Dehradun, Durgapur, Asansol, Rourkela, Nanded, Kolhapur, Ajmer, Akola
Why NIPT Test is important test in India?
NIPT is most often used to look for chromosomal disorders that are caused by the presence of an extra or missing copy (aneuploidy) of a chromosome.
NIPT is a screening test, which means that it will not give a definitive answer about whether or not a fetus has a genetic condition. In some sates and cities in India follow first cousin marriage which has been seen as a high concern for genetic abnormalities.
As per a recent study done in Mumbai, Delhi, Bangalore, Hyderabad, Ahmedabad, Chennai, Kolkata, Surat, Pune, Jaipur, Visakhapatnam, Kanpur, Nagpur, Lucknow, Thane, Bhopal, Indore, Pimpri-Chinchwad, Patna, Vadodara, Ghaziabad, Ludhiana, Agra, Nashik, Faridabad, Meerut, Rajkot, Kalyan-Dombivli, Vasai-Virar, Varanasi, Srinagar, Aurangabad, Dhanbad, Amritsar, Navi, Mumbai, Allahabad, Howrah, Ranchi, Gwalior, Jabalpur, Coimbatore, Vijayawada, Jodhpur, Madurai, Raipur, Chandigarh, Guntur, Guwahati, Solapur, Hubli–Dharwad, Mysore, Tiruchirappalli, Bareilly, Moradabad, Tiruppur, Gurgaon, Aligarh, Jalandhar, Bhubaneswar, Salem, Mira-Bhayandar, Warangal, Jalgaon, Kota, Bhiwandi, Saharanpur, Gorakhpur, Bikaner, Amravati, Noida, Jamshedpur, Bhilai, Cuttack, Firozabad, Kochi, Nellore, Bhavnagar, Dehradun, Durgapur, Asansol, Rourkela, Nanded, Kolhapur, Ajmer, Akola . It was found people marrying within community have been found to have high number of genetic disorders
How is NIPT done in india?
- An NIPT involves only a quick blood draw with a needle and syringe, it’s safe for you and your baby.
- All you’ll need to do is offer up your arm at the doctor’s office or a lab.
- Your sample is then sent to a lab, where a technician will look at the cfDNA in your blood for signs of abnormalities
Which is better Amniocentesis or NIPT?
NIPT is not perfect. Of the prenatal testing options, only amniocentesis and chorionic villus sampling (CVS) are considered diagnostic and that is why further testing is often recommended after positive results. NIPT is better–by any reasonable standard–than traditional screening tests.
Who should pregnant women get NIPT Test?
It can be done as early as the 10th week of pregnancy—even before the first blood tests and ultrasound, which can be useful for women who are over 40 and know they are at a higher risk. The test is totally safe for the baby.
What if NIPT Test is positive?
If the result is ‘positive’, ‘abnormal’ or ‘high risk’, this means your baby is likely to be affected. If you have an abnormal NIPT result, a diagnostic test such as CVS or amniocentesis can confirm the result. You should discuss your options with your doctor, midwife or genetic counsellor.
What if NIPT Test is negative?
If the result is ‘negative’, ‘normal’ or ‘low risk’, your baby is unlikely to have any of the chromosomal disorders tested. If the result is ‘positive’, ‘abnormal’ or ‘high risk’, this means your baby is likely to be affected.
Can I eat before NIPT Test?
You don’t need to do anything special to prepare for NIPT Test. You can eat and drink normally before both the blood test and the ultrasound exam.
Can NIPT test detect twins?
Non-invasive prenatal testing (NIPT) is accurate for fetal in singleton pregnancies, but its accuracy is less established in twin pregnancies. With evolution of technology and advances in science the accuracy in twins has increased.
How reliable is NIPT Test?
The test is usually conducted by specialists between 9+0 and 13+6 weeks gestation. NIPT is more than 99% accurate (with a 0.2% false positive rate), while CFTS is only around 90% accurate (with a 5% false positive rate).
What does low risk NIPT test mean?
A low risk NIPT result means that the chance for trisomy 21, trisomy 18 or trisomy 13 is less than 1:10,000. does not mean that the chances are zero. is reassuring but does not guarantee the birth of a baby without any health concerns or other genetic conditions.
What makes you high risk for Down Syndrome?
There is one key risk factor for Down syndrome i.e., maternal age. A 25-year-old woman has a 1 in 1,200 chance of having a baby with Down syndrome; by 35, the risk has increased to 1 in 350; by age 40, to 1 in 100; and by 49.
What happens if the baby is tested for Down Syndrome?
A screen positive result means that you are in a high risk group for having a baby with Down syndrome. The result is screen positive if the risk of Down syndrome in the first trimester is one in 230 or greater.
Is NIPT Test mandatory in india?
The NIPT prenatal test is a trusted elective screening tool used to assess the genetic risk of a fetal chromosomal abnormality, such as Down syndrome, in the first trimester of pregnancy.
It’s often more strongly suggested when an expecting mother has risk factors for these genetic disorders.
What causes false positives of NIPT?
- Possible causes of false positive results for trisomy 21 from NIPT include: Confined placental mosaicism (CPM)
- This is caused by a population of cells in the placenta with three copies of chromosome 21 instead of the usual two.
- Co-twin demise When one twin was lost earlier in pregnancy due to trisomy 21.
Is Down Syndrome detected at 20-week scan?
If done between 10 and 13 weeks pregnant, the blood test and ultrasound scan together will detect around 90% of babies affected with Down syndrome. If the blood test is done between 15 and 20 weeks it will identify about 75% of babies with Down syndrome.
How long does NIPT Test results take?
NIPT results usually take about 8 to 14 days. You will get a phone call when your results are ready. In a small number of pregnancies, the test is unable to give any results and repeat testing is recommended.
Does NIPT include ultrasound?
The NIPT is highly sensitive and picks up more than 99% of cases of Down syndrome. But it is still a screening test rather than a diagnostic test.
The advantage of this type of screening is that the ultrasound can pick up other problems with the pregnancy and estimate the age of the fetus.
Is NIPT more accurate than Nuchal?
There has been a subsequent tendency to abandon the previous nuchal translucency ultrasound and biochemical test because of the increased accuracy of detection of the trisomies with the NIPT test which can detect 99% of Down syndrome fetuses.
Can NIPT detect miscarriage?
A blood test can scan a fetus’s entire genome for chromosomal abnormalities at 10 weeks of pregnancy.
An extension of the non-invasive prenatal test (NIPT) for Down’s syndrome, the test could identify pregnancies that should be monitored more closely as they are at a higher risk of miscarriage or complications.
Does NIPT detects for heart defects?
- Non-invasive fetal testing, and has become a popular screening tool in assessing chromosome abnormalities when fetal anomalies are identified.
- It is suggested NIPT has low yield in fetuses with heart defects.
- Overall yield of NIPT was 64% for isolated CHD, 70.7% for non-isolated cases.
What does it mean when a baby has an extra chromosome?
A “trisomy” means that the baby has an extra chromosome in some or all of the body’s cells. In the case of trisomy 18, the baby has three copies of chromosome 18.
In the case of trisomy 13, the baby has three copies of chromosome 13. In the case of trisomy 21, the baby has three copies of chromosome 21.
Who is at risk of chromosomal abnormality?
A woman age 35 years or older is at higher risk of having a baby with a chromosomal abnormality. This is because errors in meiosis may be more likely to happen as a result of the aging process. Women are born with all of their eggs already in their ovaries.
Can Chromosomal abnormalities be cured?
Chromosomal abnormalities are genetic conditions that occur due to a problem with one of the 23 pairs of chromosomes.
In many cases, there is no treatment or cure for chromosomal abnormalities. However, genetic counseling, occupational therapy, physical therapy and medicines may be recommended.
When did NIPT testing start?
NIPT was introduced in the United States and Western Europe in late 2011, and tests are rapidly becoming available in the Middle East, South America, South and Southeast Asia, and Africa
How is risk for Down’s Syndrome calculated?
The combined risk is estimated by taking the serum‐based risk expressed as an odds and multiplying it by an NT‐based likelihood ratio.
Suppose there is a serum risk of 1 in 500 and a likelihood ratio of 10. Expressed as an odds the serum risk is 1:499 which when multiplied by 10 becomes 10:499 or 1 in 51.
Can a baby survive Edwards Syndrome?
Edwards’ syndrome affects how long a baby may survive. Sadly, most babies with Edwards’ syndrome will die before or shortly after being born. A small number (about 13 in 100) babies born alive with Edwards’ syndrome will live past their 1st birthday.
What gender does Edwards Syndrome affect?
Edwards syndrome occurs in all human populations, but is more prevalent in female offspring.
What is the life expectancy of Patau Syndrome?
The median life expectancy of Patau syndrome is 7–10 days, and 90% die in the first year of life. Survival is often attributed to mosaicism and the severity of associated malformations.
How common is Patau Syndrome?
Patau’s syndrome is a serious rare genetic disorder caused by having an additional copy of chromosome 13 in some or all of the body’s cells.
Can a person with Down Syndrome have a baby?
Women with Down syndrome are able to have children, but many men with the condition unfortunately are not able to, however it is possible.
Can Down Syndrome be cured?
Down syndrome cannot be cured. Early treatment programs can help improve skills. They may include speech, physical, occupational, and/or educational therapy.