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The NIFTY Non-Invasive Prenatal Testing (NIPT) DNA Test

The NIFTY Non-Invasive Prenatal Testing (NIPT)

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Reporting Time: 2 Week
Test Cost: 20000.00 /- Rs
Sample Type: 10 ML in Streck tube
The NIFTY Non-Invasive Prenatal Testing (NIPT) Test Description The NIFTY Non-Invasive Prenatal Testing (NIPT) NIFTY (Non-Invasive Fetal TrisomY test) is a safe, simple, non-invasive prenatal test (an NIPT), which offers screening for certain genetic conditions from as early as week 10 of pregnancy.Using the latest genetic sequencing technology, NIFTY has greater than 99% accuracy for the three most common trisomy conditions present at birth, which are Down Syndrome, Edwards Syndrome and Patau Syndrome.

NIPT is the abbreviation for Non-invasive Prenatal Testing (NIPT). NIPT test is also called as non-invasive DNA prenatal test or Cell Free DNA test or Non Invesive Fetal Testing.All the above tests use same methodology of identifying genetic anomalies in free circulating fetal DNA cell of the fetus in mother blood.

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60 Seconds Brief Video about NIPT Test - Cost 20000/- Rs

Why to get NIPT Test at DNA Labs India?

DNA Labs India is a dedicated Lab with Focus on genetics and specialized in NIPT Test. DNA Labs India has been ranked and awarded as India’s Most Trusted NIPT Test lab.
We understand its very hard to travel during pregnancy from home to lab and wait at lab to give samples. For a pregnant woman it’s a stress process and stress is not at all good for your unborn baby. We provide free home sample collection for NIPT Test patients in Delhi Mumbai Kolkata Chennai Bangalore Hyderabad and Ahmedabad.
You can reach our Delhi Lab on Cal (011) 39128834 and Book for Free Home same collection Similarly you can call Mumbai Lab on (022) 39698181, Kolkata Lab on (033) 39107669, Chennai Lab on (044) 39574844, Bangalore Lab on  (080) 33085380, Hyderabad Lab on  (040) 39564983 and Ahmedabad lab on (079) 30684184 and book for Free Home sample collection.

When to do NIPT Test ?

NIPT Test

The chromosome number of human cells should be 23 pairs (46), half of which come from father and half from mother. Normal people have 22 pairs of chromosomes, while the other pair is sex-determining sex chromosomes. It is these 23 pairs of chromosomes that make up the human genome. The cause of Down's syndrome is that there is one more chromosome on the 21st chromosome of the patient. Because there is one more chromosome 21, it is called the trisomy 21 syndrome, that is, the patient with Down syndrome. The genome is actually abnormal.
  • If Pregnant Women age greater than 32 Years go for NIPT Test

    The risk of the chromosomal aneuploid fetus is significantly higher in older pregnant women whose age is 32+. NIPT clinical data show that the aneuploidy positive rate of the three major chromosomes elderly women when agre is greater than 32 years old is 4.36%, and the aneuploidy positive rate of the three major chromosomes high-risk pregnant women when age is greater than 35 years is 11.94%.
  • If Pregnant Women Has a Family History of Genetic Conditions

    There is a 5 – 25% chance of having a baby with Down syndrome or any other trisomy if you have an affected family member. Even if the risk of trisomy is low there is a chance of the child having mosaicism or chromosomal translocation. Chromosomal Translocation form 1% of genetic risk from family history and are inherited.
  • If You had any history of miss carriage or natural abortion

    The history of miscarriage or frequent abortions can be the cause of chromosomal abnormalities or translocations that are undetected It is seen that 30% of down syndrome pregnancies that are left the undiagnosed result in miscarriage or Stillbirth.
  • If your Double marker score is abnormal or shows a high risk

    If your double marker test showed as high risk for Downs Syndrome(Trisomy 21) and you fall in any of one of the listed conditions hear. Your hospital doctor would recommend you to get NIPT Test as your chances of having downs positive baby increases to 11%. Down syndrome is the most common autosomal chromosome aneuploidy across the globe.
  • If your first baby is born with genetic problems

    If you have a baby with Down syndrome, your risk for having another increase with each pregnancy. For each pregnancy, your chances of having another baby with Down syndrome is about 1 in 100 (1 per cent) till the age of 40 years.
  • If your pregnant through IVF treatment get NIPT Test

    IVF treatment increases the risk of birth defects such as Down, patau and Edward syndrome due to the age of the mother and drugs used in the treatments. The risk of trisomy increases because of the procedure, usually, 3-5% of IVF pregnancies result in some birth defects that risk further increase with maternal and age of the donor.

Why NIPT Test for Trisomy 21 ?

Down syndrome is one of the leading genetic causes of intellectual disability in the world which is caused due to trisomy, translocation, and mosaic. This condition alone accounts for 15–20% of Down syndrome patients across the world’s population. Trisomy 21 attributes 95% of the Down Syndrome. People with Down Syndrome are susceptible to various chronic disorders, infections, and disabilities. Of all developmental disabilities such as Autism, Attention Deficit Hyperactive Disorders, and the Intellectual Disability is most common. According to population data, children are suffering from Down syndrome Hearing loss which accounts for 75%, 50-75% has a sleep disorder, and ear infection, 60% has eye disease, 50% has heart disease, and 22% have a psychiatric disorder. The condition can not be cured but is treatable if detected earlier.

Why NIPT Test for Trisomy 18 ?

Trisomy 18, the person has an extra copy of chromosome 18 is also called Edwards syndrome. This chromosomal condition is associated with abnormalities in many parts of the body. Individuals with trisomy 18 often have slow growth before birth (intrauterine growth retardation) and a low birth weight. Affected individuals may have heart defects and abnormalities of other organs that develop before birth. Other features of trisomy 18 include a small, abnormally shaped head; a small jaw and mouth; and clenched fists with overlapping fingers. Due to the presence of several life-threatening medical problems, many individuals with trisomy 18 die before birth or within their first month. Five to 10 per cent of children with this condition live past their first year, and these children often have a severe intellectual disability. This condition occurs in about 1 in 5,000 live-born infants, it is more common in pregnancy, but many affected fetuses do not survive to term. Although women of all ages can have a child with trisomy 18, the chance of having a child with this condition increases as a woman gets older.

Why NIPT Test for Trisomy 13 ?

Trisomy 13 also known as Patau syndrome is a rare developmental genetic abnormality with three copies of chromosome 13, instead of the usual two copies, there can also be a chromosomal translocation. Patau syndrome occurs in approximately 1 in 10,000 live births and mosaic trisomy 13 is thought to account for about 5% of them. Individuals with trisomy 13 often have heart defects, brain or spinal cord abnormalities, very small or poorly developed eyes, extra fingers or toes, an opening in the lip a condition known as cleft lip or without an opening in the roof of the mouth a condition known as cleft palate, and weak muscle tone a condition known as hypotonia. Due to the presence of several life-threatening medical problems, many infants with trisomy 13 die within their first days or weeks of life.

NIPT Test Details

NIFTY screens for the three most common trisomy conditions present at birth which are Down Syndrome, Edwards Syndrome and Patau Syndrome. Independent validation studies, including the worlds largest study on the use of NIPT in clinical practice in nearly 147,000 women, have shown NIFTY has an accuracy rate of over 99% for detection of these conditions.

Cell-free DNA fragments (cfDNA) are short fragments of DNA, which can be found circulating in the blood. During pregnancy, cfDNA fragments originating from both the mother and fetus are present in the maternal blood circulation.

The NIFTY test requires taking a small maternal blood sample. cfDNA in the maternal blood is then analysed with our proprietary genetic sequencing technology and bioinformatics pipelines to screen for any chromosomal abnormality in the fetus. If any abnormality is present, small excesses or deficits in counts of the affected chromosome can be detected.

The technology behind the NIFTY test allows for highly accurate results with detection rates for the three most common trisomy conditions present at birth (Down Syndrome, Edwards Syndrome and Patau Syndrome) of over 99%. But its important to understand that non-invasive prenatal tests such as NIFTY are classified as screening tests. This means that they do not test with 100% accuracy, such as with an invasive diagnostic procedure such as amniocentesis.

Trisomies: Down Syndrome (21), Edwards Syndrome (18), Patau Syndrome (13) 22 16 9

Sex Chromosome Aneuploidies: Turner Syndrome, Klinefelter Syndrome, XXX, XYY

Deletion/Duplication Syndromes: Cri-du-chat Syndrome, 1p36, 2q33.1, Prader-Willi/Angelman Syndrome (15q11.2), Jacobsen Syndrome (11q23), DiGeorge Syndrome II (10p14-p13), 16p12, Van der Woude Syndrome (1q32.2)

Remember, non-invasive prenatal testing may or may not be right for you. Prior to undertaking any non-invasive prenatal testing, you should consult a qualified healthcare professional regarding any risks, diagnoses, treatment and/or any other potentially relevant healthcare issues.