Breast ovarian cancer NGS panel PLUS Test Details:
Breast ovarian cancer panel PLUS (NGS Panel ATM, BARD1, BRIP1, CHEK2, MEN1, MLH1, MRE11A, MSH2, MSH6, MUTYH, NBN, PALB2, PMS1, PMS2, RAD50, RAD51C, RAD51D, XRCC2)
Hereditary Breast Ovarian Cancer:
Hereditary Breast and Ovarian Cancer (HBOC) Syndrome is an inherited disorder in which the risk of breast and ovarian cancer is higher than in the general population, often considerably.
People who carry these mutations may also have an increased risk of other types of cancer, including prostate cancer, pancreatic cancer and melanoma. HBOC syndrome is caused by germline mutations in genes that control tumour suppression in certain parts of the body.
According to the National Cancer Registry, breast cancer accounts for 27 per cent of all cancers in women, with one in every 28 women likely to develop it during her lifetime and one in every two women diagnosed with it succumbs.
Hereditary breast and ovarian cancer cases are on the rise in India, three times more than in western countries, said a study by leading bioinformatics firm Strand Life Sciences Ltd on Tuesday.
“Breast cancer gene mutations in the Indian population are three times more in India than in the western world due to inherited genetic disorders,” revealed the study based on the diagnosis of breast and ovarian cancer patients in the country.
What causes HBOC?
HBOC is an inherited genetic condition. This means that the cancer risk is passed from generation to generation in a family. There are 2 primary genes linked with most families who have HBOC: BRCA1 and BRCA2. BRCA stands for BReast CAncer.
Men with these gene mutations also have an increased risk of breast cancer and prostate cancer. There is a slight increase in the risk of other cancers including pancreatic cancer and melanoma among people with BRCA1 or BRCA2 mutations.
Not all families with multiple cases of breast and ovarian cancer have mutations in BRCA1 or BRCA2. There are also other genes that have been linked with an increased risk of developing breast and other cancers, such as mutations in the TP53, PTEN, CDH1, ATM, CHEK2, or PALB2 tumour suppressor genes and others.
What is the connection between breast cancer and ovarian cancer?
Breast and ovaries both are under the influence of same hormones – Estrogen and Progesterone. So, a high-risk patient is like one carrying mutations in two major genes, known as BRCA1 and BRCA2, are a frequent cause of hereditary breast/ovarian cancer.
These mutations increase the risk of developing these and other cancers. Most genetic testing for breast and ovarian cancer analyzes these two genes for mutations.
Who should be tested for HBOC?
Most breast and ovarian cancers occur by chance with no known cause, so testing for BRCA1 or BRCA2 gene mutations may not be beneficial for the average woman. These recommendations are based on your family’s history of cancer and how closely related you are to the person(s) who developed cancer.
- First-degree relatives include parents, siblings, and children.
- Second-degree relatives include aunts/uncles, grandparents, grandchildren, and nieces/nephews.
- Third-degree relatives include first-cousins, great-grandparents, or great-grandchildren.
- A family member has a known mutation in the BRCA1 or BRCA2 genes or other related breast cancer risk genes.
- A diagnosis of breast cancer at age 45 or younger.
- An unknown or limited family history.
- A personal history of male breast cancer.
- A personal history of metastatic prostate cancer.
- A personal history of ovarian cancer.
How is HBOC identified?
Mutations in the BRCA1 or BRCA2 genes can be identified through a blood or saliva test. The usual method of testing, called standard gene sequencing, can find most BRCA mutations.
There are other types of mutations called rearrangements, which include deletions or duplications in BRCA1 and BRCA2 that also may cause an increased risk for these cancers. Testing is also available for large rearrangements in BRCA1 and BRCA2.
After initial BRCA1 and BRCA2 genetic testing, additional testing may be recommended if:
- The results were “negative,” meaning no genetic mutation was detected.
- A variant of uncertain significance was detected, which means that there is a genetic change, but it is not known how that change could affect cancer risk.
What are the estimated cancer risks associated with HBOC?
Cancer risks for women with HBOC:
- The lifetime risk of breast cancer 50% to 85%
- Risk of breast cancer before age 50 30% to 50%
- The lifetime risk of ovarian cancer
- BRCA1 gene mutation 25% to 50%
- BRCA2 gene mutation 15% to 30%
- Developing a second breast cancer 40% to 60%
Cancer risks for men with HBOC
- The lifetime risk of breast cancer
- BRCA1 gene mutation 1% to 2% (10-times increase over the general population)
- BRCA2 gene mutation 6%
- Risk of prostate cancer
- BRCA1 gene mutation some increased risk
- BRCA2 gene mutation 20%
What is Breast ovarian cancer NGS panel PLUS Test?
Breast ovarian cancer NGS panel PLUS Test is a medical speciality that determines the cause and nature of diseases by examining and testing body tissues (EDTA blood or DNA). It is a Breast ovarian cancer NGS panel PLUS Test that screens for serious conditions.
What type of sample are needed to do a Breast ovarian cancer NGS panel PLUS Test?
An EDTA blood or DNA for testing can be obtained from several bodily sources. The cells are the most commonly tested are derived.
Standard Biological Breast ovarian cancer NGS panel PLUS Test Samples: EDTA blood or DNA
How accurate is Breast ovarian cancer NGS panel PLUS Test?
Breast ovarian cancer NGS panel PLUS Test is generally considered to be the most accurate testing method available. DNA Labs India’s Breast ovarian cancer NGS panel PLUS Test is considered as a benchmark by most doctors. The most precise and accurate Breast ovarian cancer NGS panel PLUS Test in India.
How many days does it take to obtain Breast ovarian cancer NGS panel PLUS Test results?
Results of Breast ovarian cancer NGS panel PLUS Test test are usually available from the laboratory within 1 week to 5 weeks.
For a standard Breast ovarian cancer NGS panel PLUS Test, DNA Labs India returns Breast ovarian cancer NGS panel PLUS Test results in 7 to 10 business days once all samples are received at the lab.
DNA Labs India understands that waiting for Breast ovarian cancer NGS panel PLUS Test results for this potentially life-changing test is stressful, so we provide speedy service without sacrificing accuracy.
Once complete, results are posted immediately to our secure online portal, and you will be notified by email right away.
Can Breast ovarian cancer NGS panel PLUS Test be done during pregnancy?
Prenatal Breast ovarian cancer NGS panel PLUS Test is a sensitive subject because of the ethical and legal issues involved, including the risks of an invasive test. You need to talk with your doctor.
How much does a Breast ovarian cancer NGS panel PLUS Test cost?
A standard Breast ovarian cancer NGS panel PLUS Test cost you 20000/- INR.
Why Choose DNA Labs India for Breast ovarian cancer NGS panel PLUS Test?
DNA labs India’s Breast ovarian cancer NGS panel PLUS Test follows with dual testing for 100% accuracy when determining a Breast ovarian cancer NGS panel PLUS Test.
- We are the leading lab for Breast ovarian cancer NGS panel PLUS Test in India
- Greater Accuracy
- Collection centres across India
- Outstanding customer service
- Strict privacy and confidentiality assured
- Full-service laboratories providing testing for use in complex cases
How to Schedule an Appointment for Breast ovarian cancer NGS panel PLUS Test?
You can either book online at the link provided. If you book and make the payment online free home collection service is provided to patients of all Breast ovarian cancer NGS panel PLUS Test.
How can I locate a Breast ovarian cancer NGS panel PLUS Test facility?
DNA labs India has 3000 plus sample collection centres across India for Breast ovarian cancer NGS panel PLUS Test.
You can choose the centre and book the Breast ovarian cancer NGS panel PLUS Test online. For all online bookings made and payment paid a free home sample collection service is provided.
List of Breast ovarian cancer NGS panel PLUS Test collection centres in India is Mumbai, Delhi, Bangalore, Hyderabad, Ahmedabad, Chennai, Kolkata, Surat, Pune, Jaipur, Visakhapatnam, Kanpur, Nagpur, Lucknow, Thane, Bhopal, Indore, Pimpri-Chinchwad, Patna, Vadodara, Ghaziabad, Ludhiana, Agra, Nashik, Faridabad, Meerut, Rajkot, Kalyan-Dombivli, Vasai-Virar, Varanasi, Srinagar, Aurangabad, Dhanbad, Amritsar, Navi, Mumbai, Allahabad, Howrah, Ranchi, Gwalior, Jabalpur, Coimbatore, Vijayawada, Jodhpur, Madurai, Raipur, Chandigarh, Guntur, Guwahati, Solapur, Hubli–Dharwad, Mysore, Tiruchirappalli, Bareilly, Moradabad, Tiruppur, Gurgaon, Aligarh, Jalandhar, Bhubaneswar, Salem, Mira-Bhayandar, Warangal, Jalgaon, Kota, Bhiwandi, Saharanpur, Gorakhpur, Bikaner, Amravati, Noida, Jamshedpur, Bhilai, Cuttack, Firozabad, Kochi, Nellore, Bhavnagar, Dehradun, Durgapur, Asansol, Rourkela, Nanded, Kolhapur, Ajmer, Akola.