Chromosomal SNP Micro Array – 750K Test Details:
A microarray is a laboratory tool used to detect the expression of thousands of genes at the same time. DNA microarrays are microscope slides that are printed with thousands of tiny spots in defined positions, with each spot containing a known DNA sequence or gene.
Often, these slides are referred to as gene chips or DNA chips. The DNA molecules attached to each slide act as probes to detect gene expression, which is also known as the transcriptome or the set of messenger RNA (mRNA) transcripts expressed by a group of the gene.
What is an SNP array?
SNPs may be associated with complex traits and multigenic disorders. PCR can only detect a few SNP at once therefore a microarray-based SNPs array is developed to screen SNPs from a genome.
The SNP microarray or SNP array has significant importance to know disease susceptibilities. And to known single-base variations associated with a complex trait.
The method is also used in drug studies, linkage analysis, population-based genotyping studies, gene mapping, and marker assistant selection studies.
The SNP is a kind of marker involved in many disorders and conditions thus it can be used to study the effect and frequency of SNP in a population and between two populations.
Chromosomal SNP Microarray:
Chromosomal Microarray is a DNA based genetic testing of individuals with unexplained developmental delay/intellectual disability (DD/ID), autism spectrum disorders (ASD), or multiple congenital anomalies (MCA).
Chromosomal Microarray Analysis Detects DNA copy number gains and losses (CNVs), loss of heterozygosity (LOH) and Uniparental Disomy (UPD), parent-of-origin analysis, enhanced detection of low-level mosaics, clonality, genomic contamination, and ploidy adjustments.