Comprehensive hereditary cancer NGS panel Test Details:
Comprehensive hereditary cancer panel 105 genes list covered (NGS Panel ALK, APC, ATM, BAP1, BLM, BMPR1A, BRIP1, CDC73, CDH1, CDK4, CDKN2A, CEBPA, CHEK2, CYLD, DDB2, DICER1, ERCC1, ERCC2, ERCC3, ERCC4, ERCC5, EXT1, EXT2, EZH2, FANCA, FANCC, FANCD2, FANCF, FANCG, FH, FLCN, GATA2, GDNF, HNF1A, HRAS, KIT, MEN1, MET, MITF, MLH1, MSH2, MSH6, MUTYH, NBN, NF1, NF2, NSD1, PALB2, PAX5, PDGFRA, PHOX2B, PMS1, PMS2, POT1, PRKAR1A, PTCH1, PTEN, RB1, RECQL4, RET, RUNX1, SBDS, SDHA, SDHB, SDHC, SDHD, SMAD4, SMARCB1, STK11, SUFU, TP53, TSC1, TSC2, VHL, WRN, WT1, XPA, XPC)
Risk factors for hereditary cancer: A hereditary cancer is any cancer caused by an inherited gene mutation.
People who are concerned about whether their family history puts them at risk for cancer should consult with a genetic counselor The features of a person’s personal or family medical history that, particularly in combination, may suggest a hereditary cancer syndrome include:
- Cancer was diagnosed at an unusually young age
- Several different types of cancer occurred in the same person
- Cancer in both organs in a set of paired organs, such as both kidneys or both breasts
- You have several first-degree relatives (mother, father, sisters, brothers, children) with cancer.
- Many relatives on one side of your family have had the same type of cancer.
- A cluster of cancers in your family have been linked to a single gene mutation (such as some types of breast, ovarian, colorectal, and pancreatic cancers).
- A family member has more than 1 type of cancer.
- Family members have had cancer at a younger age than normal for that type of cancer.
- Close relatives have cancers that are linked to hereditary cancer syndromes.
- A family member has rare cancer, such as breast cancer in a man or retinoblastoma (a type of eye cancer).
- A physical finding is linked to an inherited cancer (such as having many colon polyps).
- One or more family members have already had genetic testing that found a mutation.
- Being a member of a racial or ethnic group that is known to have an increased risk of having a certain inherited cancer susceptibility syndrome and having one or more of the above features as well Several family members with cancerUnusual cases of a specific cancer type (for example, breast cancer in a man)
- If a person is concerned that they may have an inherited cancer susceptibility syndrome in their family, it is generally recommended that, when possible, a family member with cancer have genetic counseling and testing first, to identify with more certainty if cancer in the family is due to an inherited genetic variant.
The entire coding region of a panel of genes related to hereditary cancer is examined by next-generation sequencing analysis. Additionally, portions of the flanking noncoding regions are also examined. Genes tested in this panel include ALK, APC, ATM, BAP1, BLM, BMPR1A, BRIP1, CDC73, CDH1, CDK4, CDKN2A, CEBPA, CHEK2, CYLD, DDB2, DICER1, ERCC1, ERCC2, ERCC3, ERCC4, ERCC5, EXT1, EXT2, EZH2, FANCA, FANCC, FANCD2, FANCF, FANCG, FH, FLCN, GATA2, GDNF, HNF1A, HRAS, KIT, MEN1, MET, MITF, MLH1, MSH2, MSH6, MUTYH, NBN, NF1, NF2, NSD1, PALB2, PAX5, PDGFRA, PHOX2B, PMS1, PMS2, POT1, PRKAR1A, PTCH1, PTEN, RB1, RECQL4, RET, RUNX1, SBDS, SDHA, SDHB, SDHC, SDHD, SMAD4, SMARCB1, STK11, SUFU, TP53, TSC1, TSC2, VHL, WRN, WT1, XPA, XPC.
Results are reported using ACMG guidelines and nomenclature recommended by the Human Genome Variation Society (HGVS).
Should You Get Genetic Testing for Cancer Risk?
About 5% to 10% of all cancers are thought to be related to gene mutations that are inherited or passed down through the family. Having an inherited genetic mutation does not mean you will get cancer. It means you are at a higher risk for developing a certain type or types of cancer.
Medical tests can look for many inherited gene mutations. This type of testing is called predictive genetic testing. Most people do not need this type of genetic testing. It’s usually recommended when certain types of cancer run in a family and a gene mutation is suspected.
Hereditary Cancer Syndromes:
Cancer is a common disease, so it’s no surprise that many families have at least a few members who have had cancer. Sometimes, certain types of cancer seem to run in some families. In some cases, this might be because family members share certain behaviours or exposures that increase cancer risk, such as smoking. Cancer risk might also be affected by other factors, like obesity, that tends to run in some families.
But in some cases, the cancer is caused by an abnormal gene that is being passed along from generation to generation. Although this is often referred to as inherited cancer, what is inherited is the abnormal gene that can lead to cancer, not cancer itself.
Signs of Hereditary Cancer:
There may be signs that point to an inherited mutation within a family. Sometimes the symptoms are as simple as a single-family member being diagnosed with a specific type of cancer. Other signs require looking more closely at many family members across several generations to pick up particular patterns of cancer.
Different gene mutations can cause different types of cancer. Cancers that are not due to an inherited gene change are called “sporadic cancer.” Sporadic cancer and hereditary cancer differ in several ways.
How to differentiate between Hereditary and Sporadic Cancer?
Hereditary cancers are caused in part by gene mutations passed on from parents to their children. Sporadic cancers are believed to arise from gene damage acquired from environmental exposures, dietary factors, hormones, normal ageing, and other influences.
Hereditary cancers often occur earlier than the sporadic form of same cancer. Hence, experts often recommend different screening, at a younger age for people with a gene mutation or hereditary cancer in their family. Hereditary cancers can sometimes be more aggressive than the sporadic form of same cancer.
What type of sample are needed to do a Comprehensive hereditary cancer NGS panel Test?
An EDTA blood or DNA for testing can be obtained from several bodily sources. The cells are the most commonly tested are derived.
Standard Biological Comprehensive hereditary cancer NGS panel Test Samples: EDTA blood or DNA
How accurate is the Comprehensive hereditary cancer NGS panel Test?
Comprehensive hereditary cancer NGS panel Test is generally considered to be the most accurate testing method available. DNA Labs India’s Comprehensive hereditary cancer NGS panel Test is regarded as a benchmark by most doctors. The most precise and precise Comprehensive hereditary cancer NGS panel Test in India.
How many days does it take to obtain Comprehensive hereditary cancer NGS panel Test results?
Results of Comprehensive hereditary cancer NGS panel Test test are usually available from the laboratory within one week to 5 weeks.
For a standard Comprehensive hereditary cancer NGS panel Test, DNA Labs India returns Comprehensive hereditary cancer NGS panel Test results in 7 to 10 business days once all samples are received at the lab.
DNA Labs India understands that waiting for Comprehensive hereditary cancer NGS panel Test results for this potentially life-changing test is stressful, so we provide speedy service without sacrificing accuracy.
Once complete, results are posted immediately to our secure online portal, and you will be notified by email right away.
Why Choose DNA Labs India for Comprehensive hereditary cancer NGS panel Test?
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