Overview
Hi-C sequencing is an advanced genomic technique that captures the three-dimensional (3D) organization of chromatin within the nucleus. By cross-linking DNA, digesting, and ligating fragments, it generates a comprehensive map of chromatin interactions across the genome. This technology has transformed our understanding of gene regulation, DNA replication, and genome stability. At DNA Labs India, we offer a complete Hi-C sequencing service at a cost of INR 185,000, which includes sample preparation, sequencing on Illumina platforms, and state-of-the-art bioinformatics analysis. Our expert team ensures high-quality results for research and diagnostic applications. The test is particularly valuable for investigating structural variations, enhancer-promoter interactions, and chromatin domains associated with diseases like cancer and developmental disorders. With a turnaround time of 10 weeks, we provide detailed reports that can guide clinical decisions and research directions.
To be completed — reclassified from Tests on 2026-11-13.
The purpose of Hi-C sequencing is to map the 3D architecture of the genome, revealing how chromatin folds and interacts within the nucleus. This information is crucial for understanding gene regulation, identifying disease-associated chromatin interactions, and discovering novel regulatory domains. In a clinical context, Hi-C can help diagnose genetic disorders caused by structural variants that disrupt chromatin organization, and it can uncover mechanisms underlying cancer and other diseases.
Sample requirements
What to send us
Deliverables & turnaround
What you receive
Turnaround: Reports are typically delivered within 10 weeks from the date of sample receipt.
Pricing
Transparent pricing
| Option | Turnaround | Price (INR) | Unit |
|---|---|---|---|
| Standard | Reports are typically delivered within 1... | ₹185,000 | per sample |
Limitations & precautions
What this service cannot do
Questions customers ask
Frequently asked questions
What is Hi-C sequencing?
Hi-C sequencing is a technique that captures the three-dimensional structure of chromatin by cross-linking DNA, digesting, and ligating fragments, followed by high-throughput sequencing. It reveals how the genome is organized in the nucleus.
What is the cost of Hi-C sequencing at DNA Labs India?
The cost is INR 185,000, which includes sample preparation, sequencing, and data analysis.
What sample is required for Hi-C sequencing?
Extracted DNA of high molecular weight is required. Typically, 1-2 µg of DNA is needed, which can be obtained from blood or tissue samples.
How long does it take to get results?
The turnaround time is approximately 10 weeks from sample receipt.
Is home sample collection available?
Yes, we offer free home sample collection for online bookings across major cities in India.
What are the applications of Hi-C sequencing?
Hi-C is used to study gene regulation, identify structural variants, understand disease mechanisms, and in cancer genomics.
Is fasting required before the test?
No, fasting is not required for Hi-C sequencing.
Can Hi-C sequencing be used for prenatal diagnosis?
It is not routinely used for prenatal diagnosis, but it may be used in research or specific clinical cases.
What is the difference between Hi-C and 3C?
Hi-C is a genome-wide version of 3C (Chromosome Conformation Capture), providing a comprehensive map of all chromatin interactions, whereas 3C focuses on specific loci.
Are there any risks associated with the test?
The test itself is non-invasive if blood is used. For tissue biopsy, there is a small risk of bleeding or infection.
How should I prepare for the test?
No special preparation is needed. Ensure you inform your doctor about any medications you are taking.
Will my insurance cover the cost?
Most insurance plans do not cover Hi-C sequencing as it is often considered research-based. Please check with your provider.
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