Overview
Human bisulfite sequencing and analysis is a specialized molecular technique used to map DNA methylation patterns across the genome. DNA methylation is an epigenetic modification that regulates gene expression without altering the underlying DNA sequence. Aberrant methylation patterns are implicated in numerous diseases, including cancer, neurological disorders, and cardiovascular conditions. This test involves treating extracted DNA with sodium bisulfite, which converts unmethylated cytosines to uracil while leaving methylated cytosines unchanged. The treated DNA is then sequenced using next-generation sequencing (NGS), and bioinformatics tools identify differentially methylated regions. At DNA Labs India, this test is performed with stringent quality controls and interpreted by expert geneticists. The cost is INR 120000, inclusive of sample collection, processing, and a comprehensive report. Results are typically available within 10 weeks. This test is invaluable for researchers and clinicians seeking to understand epigenetic contributions to disease and for guiding personalized treatment strategies.
To be completed — reclassified from Tests on 2026-11-13.
The primary purpose of human bisulfite sequencing is to identify and quantify DNA methylation changes that may contribute to disease pathogenesis. It aids in diagnosing conditions where methylation abnormalities are known, such as imprinting disorders, certain cancers, and neurodevelopmental syndromes. Additionally, it can be used for prognostic assessment and monitoring therapeutic response in oncology. By providing a genome-wide methylation profile, this test offers insights that complement traditional genetic testing.
Sample requirements
What to send us
Deliverables & turnaround
What you receive
Turnaround: 10 weeks
Pricing
Transparent pricing
| Option | Turnaround | Price (INR) | Unit |
|---|---|---|---|
| Standard | 10 weeks | ₹120,000 | per sample |
Limitations & precautions
What this service cannot do
Questions customers ask
Frequently asked questions
What is human bisulfite sequencing?
It is a technique to analyze DNA methylation patterns by treating DNA with sodium bisulfite and sequencing it.
What is the cost of the test?
The cost is INR 120000, inclusive of sample collection, processing, and report.
What sample is required?
Extracted DNA, typically from blood or tissue.
How long does it take to get results?
Results are available in approximately 10 weeks.
Is fasting required?
No, fasting is not required.
Can this test detect cancer?
It can identify methylation changes associated with cancer, but it is not a standalone cancer diagnostic.
Is home sample collection available?
Yes, we offer free home sample collection for online bookings across India.
What diseases can be diagnosed?
It helps diagnose imprinting disorders, certain cancers, and neurodevelopmental conditions.
Are there any risks?
Risks are minimal, mainly related to blood collection.
Will insurance cover this test?
Generally not covered; please check with your provider.
How should I prepare?
No special preparation is needed.
What does the report include?
The report includes methylation profiles, interpretation, and clinical recommendations.
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