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ADAM22 Gene Neurodevelopmental disorder, ADAM22 related NGS Genetic Test

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ADAM22 Gene Neurodevelopmental disorder, ADAM22 related NGS Genetic Test

Short Name: ADAM22 NGS Genetic Test

Also known as: ADAM22 Gene Mutation Analysis, ADAM22-related Disorder NGS Panel, Neurodevelopmental Disorder NGS Panel (ADAM22 Gene), ADAM22 Genetic Testing

ADAM22 Gene Neurodevelopmental disorder, ADAM22 related NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next Generation Sequencing (NGS), Sanger Sequencing for variant confirmation on Blood samples. Results in Results are generally available within 3 to 4 weeks of receipt of the blood sample. The exact time may vary depending on sequencing batch and additional confirmation testing.. Free home collection in 300+ cities across India.

NGS Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SHAILAJA RAGHUNATH MURDESHWAR

Dr SHAILAJA RAGHUNATH MURDESHWAR

Consultant Physician · Reg: 8052

Last reviewed: September 7, 2026

Overview

The primary purpose of the ADAM22 gene NGS genetic test is to identify pathogenic variants in the ADAM22 gene that may be responsible for neurodevelopmental deficits, seizures, and related neurological manifestations. This test assists in confirming a clinical diagnosis, guiding prognosis, enabling early therapeutic interventions, and providing accurate recurrence risk information for family members.

Test Code
4413
CPT Code
81407
ICD Code
F88
Price
₹20,000
Sample Type
Blood
Result Time
Results are generally available within 3 to 4 weeks of receipt of the blood sample. The exact time may vary depending on sequencing batch and additional confirmation testing.
Fasting Required
No
Method
Next Generation Sequencing (NGS), Sanger Sequencing for variant confirmation
Step 1

Sample Collection

No fasting required. A genetic counseling session will be carried out prior to the test to review clinical history, obtain informed consent, and draw a pedigree chart of family members affected with neurodevelopmental disorders.

Method: Peripheral venipuncture

Step 2

Laboratory Analysis

A blood sample will be collected from a vein in the arm. The procedure is brief and routine.

Step 3

Report Delivery

After blood collection, you may leave the facility immediately. No special precautions are required. The sample is sent to the genetics laboratory for NGS analysis.

Timeline: Results are generally available within 3 to 4 weeks of receipt of the blood sample. The exact time may vary depending on sequencing batch and additional confirmation testing.

Patient Instructions

1
Before the Test:Prior to the NGS test, all patients undergo a pre-test genetic counseling session. The clinician will review the family history, discuss the benefits and limitations of testing, and obtain informed consent.
2
During the Test:A trained phlebotomist collects a blood sample. No anesthesia or fasting is required. The sample is transported to the genetics laboratory for DNA extraction, library preparation, and NGS sequencing.
3
After the Test:The results are interpreted by molecular geneticists and will be made available in a detailed report. A follow-up genetic consultation is scheduled to discuss results, their implications for treatment and family members, and reproductive options if applicable.

About This Test

Who Should Get This Test

The primary purpose of the ADAM22 gene NGS genetic test is to identify pathogenic variants in the ADAM22 gene that may be responsible for neurodevelopmental deficits, seizures, and related neurological manifestations. This test assists in confirming a clinical diagnosis, guiding prognosis, enabling early therapeutic interventions, and providing accurate recurrence risk information for family members.

How to Prepare

  • No fasting or special preparation is needed.
  • Please carry any previous medical records, imaging, and prior genetic test reports if available.
  • An EDTA blood sample (2-3 mL) is collected from the patient.
  • In case of a child, a guardian’s presence is mandatory.
  • Ensure the sample is labeled with complete patient identification details.
  • The sample should be transported to the laboratory within 24 hours if collected at home.

Doctor's Notes

Reviewed by — MBBS, MD (General Medicine) · Reg. No. 8052

"The ADAM22 gene plays a critical role in synaptic organization and neural development. NGS-based testing provides comprehensive screening of the gene, helping in precise diagnosis of ADAM22-related neurodevelopmental disorders. Early genetic diagnosis enables better seizure management, developmental support, and family counseling."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood
Sample Volume2-3 mL
ContainerEDTA vacutainer
Collection MethodPeripheral venipuncture

Sample Stability

Room Temperature (20-25°C)
Refrigerated (2-8°C)
Frozen (-20°C)
Sample Rejection Criteria:
  • Clotted or hemolyzed blood sample
  • Incorrect anticoagulant tube (e.g., heparinized tube instead of EDTA)
  • Frozen whole blood without previous processing
  • Sample without proper labeling or requisition form
  • Sample received after more than 5 days of collection
  • Baby samples with insufficient volume (<1 mL)

Understanding Your Results

The result of the ADAM22 NGS test is interpreted based on the presence or absence of pathogenic variants in the ADAM22 gene. Sequence variants are classified according to the American College of Medical Genetics and Genomics (ACMG) guidelines into five categories: Pathogenic, Likely Pathogenic, Variant of Uncertain Significance (VUS), Likely Benign, and Benign.
📊

Pathogenic / Likely Pathogenic variant identified

The individual has a molecular diagnosis of ADAM22-related disorder. Clinical management should be tailored according to symptoms. Predictive testing of at-risk family members may be offered.

📊

Variant of Uncertain Significance (VUS) identified

A genetic variant was found but its clinical significance is currently unknown. Additional family segregation studies or functional studies may be required to clarify the variant’s role.

📊

No pathogenic variant detected

No clinically significant variants were identified in the ADAM22 gene. This does not rule out a genetic cause; other genes or conditions should be considered.

⚠️ When to Consult a Doctor:

If you or your child have neurodevelopmental delays, seizures, intellectual disability, or a family history of genetic neurological disorders, please consult a clinical geneticist or neurologist. If the test result is positive or uncertain, a genetic counselor or clinical geneticist should be consulted to discuss the implications and next steps.

Limitations

  • ⚠This test detects mutations in the coding exons and splice junctions of the ADAM22 gene only; mutations in regulatory regions or deep intronic regions may not be identified.
  • ⚠Large deletions, duplications, or complex structural rearrangements may require additional testing such as chromosomal microarray or MLPA.
  • ⚠Not all sequence variants will be determined to be clinically significant; uncertain variants may be reported and require further family studies.
  • ⚠Negative results do not completely exclude a genetic cause, as mutations in other genes may phenotypically mimic ADAM22-related disorder.
  • ⚠There is a small chance of diagnostic error due to rare technical artifacts, low-level mosaicism, or allele dropout.

Risks & Considerations

  • ●Pain or bruising at the blood collection site, Mild and temporary
  • ●Fainting or dizziness during blood draw, Rare
  • ●Infection (rare), Minimal if standard sterile procedures are followed

Interfering Factors

  • ●Presence of pseudogenes or homologous genomic regions may occasionally affect sequencing alignment
  • ●High GC content in certain exons may impact sequence coverage
  • ●Very rare intronic mutations or deep intronic changes not captured by standard exonic NGS
  • ●Contamination of sample with other human DNA
  • ●Technical limitations in detecting large rearrangements, especially with uniparental disomy or mosaic variants

Compare With Similar Tests

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Frequently Asked Questions

What is the cost of the ADAM22 NGS genetic test at DNA Labs India?
The cost is INR 20,000. This includes genetic counseling, NGS sequencing, data analysis, and a comprehensive clinical report. Home sample collection is free for online bookings.
What type of sample is required for the ADAM22 gene test?
A blood sample is required. The sample is collected in an EDTA vacutainer, typically 2-3 mL of whole blood.
Is fasting necessary before the ADAM22 NGS test?
No, fasting is not required for this genetic test. The blood sample can be collected at any time of the day.
How long does it take to get the ADAM22 gene test results?
The reports are generally available within 3 to 4 weeks after the sample reaches the laboratory.
Is the ADAM22 NGS test covered by insurance?
Generally, genetic tests for neurodevelopmental disorders are not covered by most insurance plans. You may need to pay out-of-pocket, but it is advisable to check with your specific insurance provider for any reimbursement possibilities.
Does DNA Labs India provide home sample collection for this test?
Yes, we offer free home sample collection for online bookings across India, including all major cities.
What conditions can be detected by the ADAM22 gene NGS test?
The test detects pathogenic variants in the ADAM22 gene, which are associated with intellectual disability, epileptic seizures, developmental delay, speech and behavioral problems, and other neurological features.
What is the role of genetic counseling in this test?
Pre-test genetic counseling helps obtain informed consent and family history. Post-test counseling is done to discuss the results, medical management, and implications for family members.
Are there any false-negative or false-positive results?
As with all genetic tests, there is a small risk of false-negative or false-positive due to technical limitations, rare variant types, or human error. Our laboratory follows strict QC protocols and confirms positive findings with Sanger sequencing.
Can this test be done on an infant?
Yes, the test can be performed on children of any age, including newborns, provided a blood sample of adequate volume (minimum 1 mL) is collected.
What does a Variant of Uncertain Significance (VUS) result mean?
A VUS indicates that a genetic variant was identified, but its effect on the ADAM22 gene function is not yet known. Additional testing of family members may help clarify the significance.
Are the results confidential?
Yes, all genetic test results are strictly confidential and shared only with the ordering physician or the patient/guardian as per applicable privacy regulations.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

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