AML1/ETO (AML - M2) Test
Short Name: AML1/ETO
Also known as: RUNX1/RUNX1T1, t(8;21) FISH, AML1/ETO translocation
AML1/ETO (AML - M2) Test test available at DNA Labs India for ₹5,250. Uses Fluorescence In Situ Hybridization (FISH) on Bone Marrow / Peripheral Blood samples. Results in Reports are typically available within 3-4 days after sample collection.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
The purpose of the AML1/ETO (AML-M2) test is to detect the t(8;21) chromosomal translocation that results in the AML1/ETO fusion gene. This test aids in: confirming the diagnosis of AML-M2, providing prognostic information, guiding treatment decisions, and monitoring for residual disease after therapy. It is also used in the initial workup of acute leukemia to classify the subtype and assess risk.
- Test Code
- 6034
- CPT Code
- 88271
- ICD Code
- C92.0
- Price
- ₹5,250
- Sample Type
- Bone Marrow / Peripheral Blood
- Result Time
- Reports are typically available within 3-4 days after sample collection.
- Fasting Required
- No
- Method
- Fluorescence In Situ Hybridization (FISH)
Sample Collection
No fasting required. A doctor's prescription is mandatory. Inform your physician about any medications you are taking.
Method: Venipuncture or Bone Marrow Aspiration
Laboratory Analysis
A blood sample will be drawn from a vein in your arm, or a bone marrow aspirate will be collected by a specialist. The procedure is quick and may cause mild discomfort.
Report Delivery
You can resume normal activities immediately. If bone marrow biopsy was performed, keep the site clean and dry for 24 hours.
Timeline: Reports are typically available within 3-4 days after sample collection.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of the AML1/ETO (AML-M2) test is to detect the t(8;21) chromosomal translocation that results in the AML1/ETO fusion gene. This test aids in: confirming the diagnosis of AML-M2, providing prognostic information, guiding treatment decisions, and monitoring for residual disease after therapy. It is also used in the initial workup of acute leukemia to classify the subtype and assess risk.
How to Prepare
- Bring a valid doctor's prescription
- Inform the lab if you are pregnant or planning to travel abroad
- No fasting required
- Ensure the sample is collected in a Sodium Heparin vacutainer
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"The AML1/ETO fusion is a favorable prognostic marker in AML. Early detection via FISH helps guide targeted therapy and risk stratification."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Clotted sample
- Hemolyzed sample
- Incorrect container
- Sample not labeled properly
- Sample received after 48 hours
Understanding Your Results
Positive
Confirms AML-M2 with t(8;21). Associated with good response to cytarabine-based therapy and higher remission rates.
Negative
No t(8;21) detected. Other genetic tests may be needed to identify alternative mutations.
Consult your oncologist if you experience symptoms such as persistent fatigue, unexplained fever, frequent infections, easy bruising, or bone pain. Early diagnosis and treatment are critical for better outcomes.
Limitations
- ⚠FISH only detects the specific t(8;21) translocation; other mutations may be missed
- ⚠Results should be interpreted in conjunction with morphology and other genetic tests
- ⚠Low-level residual disease may not be detected by FISH; more sensitive methods like PCR may be needed
Risks & Considerations
- ●Minimal risk of bleeding or infection at the puncture site
- ●Bone marrow biopsy may cause temporary pain or discomfort
- ●Rare risk of nerve damage (very low)
Interfering Factors
- ●Hemolyzed or clotted samples may affect FISH analysis
- ●Insufficient bone marrow aspirate may yield inadequate metaphase cells
- ●Recent blood transfusion may dilute leukemic cells
- ●Prior chemotherapy may reduce abnormal cell count
Compare With Similar Tests
| Test | AML1/ETO (AML - M2) | PML/RARA (APL) | FLT3-ITD Mutation | NPM1 Mutation |
|---|---|---|---|---|
| Comparison | AML1/ETO (AML - M2) |
Frequently Asked Questions
What is the AML1/ETO (AML-M2) test?
What is the cost of the AML1/ETO test in India?
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What sample is needed?
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Is home sample collection available?
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