Anti-MOG (Myelin Oligodendrocyte Glycoprotein) CSF Test
Short Name: Anti-MOG CSF Test
Also known as: MOG Antibody CSF Test, Anti-Myelin Oligodendrocyte Glycoprotein Antibody CSF Test, MOG-IgG CSF Test, MOG Ab Cerebrospinal Fluid Test
Anti-MOG (Myelin Oligodendrocyte Glycoprotein) CSF Test test available at DNA Labs India for ₹9,000. Uses Cell Based Assay (CBA), Immunofluorescence Assay (IFA) on Cerebrospinal Fluid (CSF) samples. Results in Same day report after sample reaches the laboratory. Samples accepted on Tuesday and Friday by 9 AM.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SHAILAJA RAGHUNATH MURDESHWAR
Consultant Physician · Reg: 8052
Last reviewed: September 7, 2026
Overview
The purpose of the Anti-MOG CSF Test is to detect and quantify anti-MOG antibodies in cerebrospinal fluid to aid in the diagnosis of anti-MOG antibody-associated disease (MOGAD). This test helps differentiate MOGAD from other demyelinating conditions such as classic multiple sclerosis and aquaporin-4 antibody-positive NMOSD, as the treatment approach and prognosis may differ. It is used as an adjunct to clinical evaluation and neuroimaging in patients presenting with inflammatory CNS demyelinating syndromes.
- Test Code
- 161
- Price
- ₹9,000
- Sample Type
- Cerebrospinal Fluid (CSF)
- Result Time
- Same day report after sample reaches the laboratory. Samples accepted on Tuesday and Friday by 9 AM.
- Fasting Required
- No
- Method
- Cell Based Assay (CBA), Immunofluorescence Assay (IFA)
Sample Collection
No special preparation is needed prior to sample collection. Patients should inform their doctor about any medications, especially immunosuppressants or corticosteroids, as these may affect results. The lumbar puncture procedure itself requires informed consent.
Method: Lumbar Puncture
Laboratory Analysis
CSF is collected via lumbar puncture (spinal tap). A sterile needle is inserted into the subarachnoid space, typically between the L3-L4 or L4-L5 vertebrae, and approximately 1 mL of cerebrospinal fluid is collected into a sterile screw-capped container. The procedure is performed under aseptic conditions.
Report Delivery
After sample collection, patients may be advised to lie flat for a period to reduce the risk of post-lumbar puncture headache. The CSF sample must be shipped refrigerated or frozen to the laboratory. Reports are typically available on the same day the sample reaches the laboratory.
Timeline: Same day report after sample reaches the laboratory. Samples accepted on Tuesday and Friday by 9 AM.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of the Anti-MOG CSF Test is to detect and quantify anti-MOG antibodies in cerebrospinal fluid to aid in the diagnosis of anti-MOG antibody-associated disease (MOGAD). This test helps differentiate MOGAD from other demyelinating conditions such as classic multiple sclerosis and aquaporin-4 antibody-positive NMOSD, as the treatment approach and prognosis may differ. It is used as an adjunct to clinical evaluation and neuroimaging in patients presenting with inflammatory CNS demyelinating syndromes.
How to Prepare
- CSF sample must be collected via lumbar puncture by a qualified medical professional
- Collect minimum 0.5 mL CSF; 1 mL recommended in a sterile screw-capped container
- Ship the sample refrigerated (2-8°C) or frozen
- Label the container with patient details, date, and time of collection
- Avoid blood-contaminated samples; note if contamination is present
- Maintain the cold chain during transport
Doctor's Notes
Reviewed by Dr SHAILAJA RAGHUNATH MURDESHWAR — MBBS, MD (General Medicine) · Reg. No. 8052
"Anti-MOG antibody testing in cerebrospinal fluid is a valuable tool in the diagnostic workup of patients presenting with demyelinating neurological syndromes. Positive results can help differentiate anti-MOG antibody-associated disease (MOGAD) from multiple sclerosis and neuromyelitis optica spectrum disorder (NMOSD), as treatment strategies may differ. A positive CSF result, in the appropriate clinical context, supports the diagnosis and guides management. This test should always be interpreted alongside clinical findings, MRI results, and other laboratory investigations by a qualified neurologist."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Sample with gross blood contamination
- Sample received at room temperature beyond 6 hours of collection
- Insufficient sample volume (less than 0.5 mL)
- Leaking or non-sterile container
- Unlabelled or mislabelled samples
Understanding Your Results
Negative
No anti-MOG antibodies detected in CSF. This makes anti-MOG antibody-associated disease (MOGAD) less likely, though a negative result cannot completely rule it out, especially if collected late in the disease course or after immunosuppressive treatment.
Positive (Low Titer)
Anti-MOG antibodies detected at a low level. Correlation with clinical presentation and imaging is recommended. Repeat testing may be considered.
Positive (High Titer)
Anti-MOG antibodies detected at a high level. Strongly supportive of anti-MOG antibody-associated disease (MOGAD) in the appropriate clinical context. The treating neurologist will determine the treatment plan based on the complete clinical picture.
Consult a neurologist if you experience unexplained vision loss or blurred vision, weakness or numbness in the limbs, difficulty walking, loss of bladder or bowel control, or any other persistent neurological symptoms. If you have been diagnosed with or are being evaluated for multiple sclerosis, NMOSD, or recurrent optic neuritis, discuss with your doctor whether anti-MOG antibody testing is appropriate for you.
Limitations
- ⚠A positive anti-MOG antibody result alone does not confirm a diagnosis; clinical correlation is essential
- ⚠Antibody titers may fluctuate over the course of disease and may not always correlate with disease severity
- ⚠This test is qualitative or semi-quantitative; quantitative monitoring may require serum testing alongside CSF
- ⚠Cross-reactivity with other myelin-associated antigens is rare but possible
- ⚠Results should always be interpreted by a qualified neurologist in conjunction with imaging and clinical findings
Risks & Considerations
- ●Post-lumbar puncture headache (most common, usually self-limiting)
- ●Mild pain or discomfort at the puncture site
- ●Rarely, infection at the needle insertion site
- ●Very rarely, bleeding or nerve damage
Interfering Factors
- ●Recent administration of immunosuppressive therapy or plasma exchange may reduce antibody levels and produce false-negative results
- ●Sample contamination or improper handling of CSF may affect test accuracy
- ●Timing of sample collection relative to disease onset may influence antibody detectability
- ●Presence of blood contamination in the CSF sample
Compare With Similar Tests
| Test | Anti-MOG (Myelin Oligodendrocyte Glycoprotein) CSF Test | Anti-MOG Serum Test | Anti-AQP4 Antibody Test | Oligoclonal Bands (OCB) Test |
|---|---|---|---|---|
| Comparison | Anti-MOG (Myelin Oligodendrocyte Glycoprotein) CSF Test | Detects anti-MOG antibodies in blood (serum) rather than CSF. Serum testing is less invasive but may have different sensitivity compared to CSF testing. Both may be ordered together for comprehensive evaluation. | Detects aquaporin-4 antibodies associated with neuromyelitis optica spectrum disorder (NMOSD). Used to differentiate NMOSD from MOGAD and multiple sclerosis. AQP4 and MOG antibody testing are often ordered together. | Detects oligoclonal immunoglobulin bands in CSF, commonly associated with multiple sclerosis. OCBs are typically absent in MOGAD, making this test useful in differentiating the two conditions. |
Frequently Asked Questions
What is the Anti-MOG CSF Test?
Why is the Anti-MOG CSF Test performed?
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Is the Anti-MOG CSF Test painful?
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What is the difference between the Anti-MOG CSF Test and the Anti-MOG Serum Test?
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