BCR-ABL (CML, AML, ALL) Test
Short Name: BCR-ABL FISH
Also known as: BCR-ABL Translocation Test, Philadelphia Chromosome Test, BCR-ABL FISH
BCR-ABL (CML, AML, ALL) Test test available at DNA Labs India for ₹5,250. Uses Fluorescence In Situ Hybridization (FISH) on Bone Marrow / Peripheral Blood samples. Results in Reports are typically available within 3-4 days after sample collection.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
The purpose of the BCR-ABL FISH test is to detect the presence of the BCR-ABL fusion gene, which is indicative of the Philadelphia chromosome. This test is used for: 1) Diagnosing CML, and sometimes AML and ALL, 2) Confirming the presence of the Philadelphia chromosome in suspected cases, 3) Monitoring the effectiveness of treatment, especially TKI therapy, 4) Detecting minimal residual disease after treatment, 5) Predicting prognosis and guiding therapeutic decisions.
- Test Code
- 6043
- CPT Code
- 88271, 88275, 88291
- ICD Code
- C92.1, C92.0, C91.0
- Price
- ₹5,250
- Sample Type
- Bone Marrow / Peripheral Blood
- Result Time
- Reports are typically available within 3-4 days after sample collection.
- Fasting Required
- No
- Method
- Fluorescence In Situ Hybridization (FISH)
Sample Collection
No special preparation is required. However, a doctor's prescription is mandatory. Inform your doctor about any medications you are taking.
Method: Venipuncture or Bone Marrow Aspiration
Laboratory Analysis
A blood sample will be drawn from a vein in your arm, or a bone marrow sample may be collected by a healthcare professional. The procedure is quick and generally well-tolerated.
Report Delivery
You can resume normal activities immediately. If a bone marrow biopsy was performed, follow your doctor's instructions for care at the biopsy site.
Timeline: Reports are typically available within 3-4 days after sample collection.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of the BCR-ABL FISH test is to detect the presence of the BCR-ABL fusion gene, which is indicative of the Philadelphia chromosome. This test is used for: 1) Diagnosing CML, and sometimes AML and ALL, 2) Confirming the presence of the Philadelphia chromosome in suspected cases, 3) Monitoring the effectiveness of treatment, especially TKI therapy, 4) Detecting minimal residual disease after treatment, 5) Predicting prognosis and guiding therapeutic decisions.
How to Prepare
- Ensure the sample is collected in a Sodium Heparin Vacutainer
- For bone marrow, the sample must be collected by a qualified professional
- Label the sample correctly with patient details
- Transport the sample to the laboratory at ambient temperature
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"BCR-ABL FISH is essential for diagnosing CML and monitoring treatment response. Early detection significantly improves outcomes."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Clotted sample
- Hemolyzed sample
- Incorrect container
- Sample not labeled properly
- Sample received after 24 hours
Understanding Your Results
Indicates presence of Philadelphia chromosome; consistent with CML, or a subset of ALL/AML. Further evaluation and treatment planning required.
No evidence of the Philadelphia chromosome; other genetic abnormalities may be considered.
Consult your doctor if you experience persistent symptoms such as fatigue, fever, unexplained weight loss, or swollen lymph nodes. Early consultation and testing can lead to timely diagnosis and better management.
Limitations
- ⚠FISH may not detect rare variant translocations
- ⚠Results should be correlated with clinical and morphological findings
- ⚠Not a substitute for bone marrow biopsy in all cases
- ⚠May not detect very low levels of disease (below FISH sensitivity)
Risks & Considerations
- ●Minimal risk of bleeding or infection at the blood draw site
- ●Rare risk of bone marrow biopsy complications (bleeding, infection, pain)
Interfering Factors
- ●Recent blood transfusion may dilute abnormal cells
- ●Inadequate sample volume or clotted sample
- ●Prior chemotherapy may reduce abnormal cell count
- ●Sample not processed within recommended time
Compare With Similar Tests
| Test | BCR-ABL (CML, AML, ALL) | BCR-ABL PCR | Cytogenetic Analysis (Karyotyping) | Bone Marrow Biopsy |
|---|---|---|---|---|
| Comparison | BCR-ABL (CML, AML, ALL) | PCR is more sensitive than FISH and can quantify minimal residual disease, while FISH is qualitative and useful for initial diagnosis. | Karyotyping detects the Philadelphia chromosome but requires dividing cells and is less sensitive than FISH. | Bone marrow biopsy provides morphological information about cell types and blast percentage, complementing FISH results. |
Frequently Asked Questions
What is the BCR-ABL FISH test?
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What is the sample type required?
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How long does it take to get results?
Is a doctor's prescription necessary?
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Is home sample collection available?
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