ICAM1 Gene and Malaria: Susceptibility and Diagnosis
Malaria is a life-threatening disease that affects millions of people worldwide. It is caused by the Plasmodium parasite and transmitted through the bites of infected mosquitoes. One of the key factors that contribute to the susceptibility of malaria is genetics. In particular, the ICAM1 gene has been identified as a potential risk factor for cerebral malaria, a severe form of the disease that can cause brain damage and even death.
What is the ICAM1 Gene?
The ICAM1 gene encodes a protein called intercellular adhesion molecule 1 (ICAM-1), which is involved in the immune response. ICAM-1 is expressed on the surface of cells and plays a role in cell-to-cell adhesion, leukocyte migration, and inflammation. It is also a receptor for the Plasmodium parasite, which means that it can facilitate the invasion of red blood cells by the parasite.
ICAM1 Gene and Malaria Susceptibility
Several studies have shown that variants in the ICAM1 gene are associated with an increased risk of cerebral malaria. Cerebral malaria is a severe form of the disease that affects the brain and can cause coma, seizures, and other neurological symptoms. The exact mechanisms by which ICAM-1 contributes to the development of cerebral malaria are not fully understood, but it is thought to be related to the adhesion of infected red blood cells to the blood vessels in the brain.
Diagnosis of Malaria and ICAM1 Gene Testing
The diagnosis of malaria is typically based on clinical symptoms, such as fever, chills, headache, and muscle pain, combined with laboratory tests to confirm the presence of the parasite. However, genetic testing can also be used to identify individuals who may be at higher risk of developing severe forms of the disease, such as cerebral malaria.
Next-generation sequencing (NGS) is a powerful tool that can be used to analyze multiple genes simultaneously. DNA Labs India offers an NGS genetic test that includes the ICAM1 gene, as well as other genes associated with malaria susceptibility. The test costs INR 20,000 and can provide valuable information about an individual’s risk of developing severe forms of malaria.
Conclusion
The ICAM1 gene has been identified as a potential risk factor for cerebral malaria, a severe form of the disease that can cause brain damage and even death. Genetic testing can provide valuable information about an individual’s risk of developing severe forms of malaria, and DNA Labs India offers an NGS genetic test that includes the ICAM1 gene. If you are concerned about your risk of malaria, talk to your healthcare provider about genetic testing.
Remember to take precautions to prevent mosquito bites, such as using insect repellent, wearing long-sleeved clothing, and sleeping under mosquito nets, especially if you are travelling to areas where malaria is endemic.
Stay safe and stay healthy!
Before getting tested ask for Raw Data, FASTQ, and VCF files along with clinical test report from DNA Testing Lab. DNA Labs India is the Only lab that is transparent and will share Raw Data, FASTQ, and VCF files along with the conclusive clinical report for ICAM1 Gene Malaria, cerebral, susceptibility to NGS Genetic Test
| Test Name | ICAM1 Gene Malaria, cerebral, susceptibility to NGS Genetic Test |
|---|---|
| Sample type | Blood or Extracted DNA or One drop Blood on FTA Card |
| Test type | Dermatologist |
| Pre-test Information | Clinical History of Patient who is going for ICAM1 Gene Malaria, cerebral, susceptibility to NGS Genetic Test. A Genetic Counselling session to draw a pedigree chart of family members affected with ICAM1 Gene Malaria, cerebral, susceptibility to NGS Genetic Test gene ICAM1 |
| Disease | Osteology Dermatology Immunology Disorders |
| Method | NGS Technology |
| Purpose | NULL |
| Preparation | Ambient Room Temperature |
| Fasting | Clinical History of Patient who is going for ICAM1 Gene Malaria, cerebral, susceptibility to NGS Genetic Test. A Genetic Counselling session to draw a pedigree chart of family members affected with ICAM1 Gene Malaria, cerebral, susceptibility to NGS Genetic Test gene ICAM1 |
| Get Reports | 3 to 4 Weeks |
| Test Price | INR ₹ 20000 |
Note: We offer free home sample collection for online bookings for ICAM1 Gene Malaria, cerebral, susceptibility to NGS Genetic Test and the test costs a special discounted price of 20000 INR across India. The cities where this service is available include Mumbai, Delhi, Bangalore, Hyderabad, Ahmedabad, Chennai, Kolkata, Surat, Pune, Jaipur, Lucknow, Kanpur, Nagpur, Indore, Thane, Bhopal, Visakhapatnam, Pimpri-Chinchwad, Patna, Vadodara, Ghaziabad, Ludhiana, Agra, Nashik, Faridabad, Meerut, Rajkot, Kalyan-Dombivali, Vasai-Virar, Varanasi, Srinagar, Aurangabad, Dhanbad, Amritsar, Navi Mumbai, Prayagraj, Howrah, Ranchi, Jabalpur, Gwalior, Coimbatore, Vijayawada, Jodhpur, Madurai, Raipur, Kota, Guwahati, Chandigarh, Thiruvananthapuram, Solapur, Hubballi-Dharwad, Tiruchirappalli, Tiruppur, Moradabad, Mysore, Bareily, Gurgaon, Aligarh, Jalandhar, Bhubaneswar, Salem, Mira-Bhayandar, Warangal , Guntur , Bhiwandi, Saharanpur, Gorakhpur, Bikaner, Amravati, Noida, Jamshedpur, Bhilai, Cuttack, Firozabad, Kochi, Nellore , Bhavnagar, Dehradun, Durgapur, Asansol, Rourkela, Nanded, Kolhapur, Ajmer, Akola, Gulbarga, Jamnagar, Ujjain, Loni, Siliguri, Jhansi, Ulhasnagar, Jammu, Sangli-Miraj & Kupwad, Mangalore, Erode10, Belgaum, Ambattur, Tirunelveli, Malegaon, Gaya, Jalgaon, Udaipur, Maheshtala, Davanagere, Kozhikode, Kurnool, Rajpur Sonarpur, Rajahmundry , Bokaro, South Dumdum, Bellary, Patiala, Gopalpur, Agartala, Bhagalpur, Muzaffarnagar, Bhatpara, Panihati, Latur, Dhule, Tirupati , Rohtak, Korba, Bhilwara, Berhampur, Muzaffarpur, Ahmednagar, Mathura, Kollam, Avadi, Kadapa, Kamarhati, Sambalpur, Bilaspur, Shahjahanpur, Satara, Bijapur, Rampur, Shivamogga, Chandrapur, Junagadh, Thrissur, Alwar, Bardhaman, Kulti, Kakinada, Nizamabad, Parbhani, Tumkur, Khammam, Ozhukarai, Bihar Sharif, Panipat, Darbhanga, Bally, Aizawl, Dewas, Ichalkaranji, Karnal, Bathinda, Jalna, Eluru, Kirari Suleman Nagar, Barasat, Purnia, Satna, Mau, Sonipat, Farrukhabad, Sagar, Rourkela, Durg, Imphal, Ratlam, Hapur, Arrah, Karimnagar, Anantapur, Etawah, Ambernath, North Dumdum, Bharatpur, Begusarai, New Delhi, Gandhidham, Baranagar, Tiruvottiyur, Puducherry, Sikar, Thoothukudi, Rewa, Mirzapur, Raichur, Pali, Ramagundam , Haridwar, Vijayanagaram, Katihar, Nagarcoil, Sri Ganganagar, Karawal Nagar, Mango, Thanjavur, Bulandshahr, Uluberia, Murwara, Sambhal, Singrauli, Nadiad, Secunderabad, Naihati, Yamunanagar, Bidhan Nagar, Pallavaram, Bidar, Munger, Panchkula, Burhanpur, Raurkela Industrial Township, Kharagpur, Dindigul, Gandhinagar, Hospet, Nangloi Jat, Malda, Ongole, Deoghar, Chapra, Haldia, Khandwa, Nandyal, Chittoor , Morena, Amroha, Anand, Bhind, Bhalswa Jahangir Pur, Madhyamgram, Bhiwani, Navi Mumbai Panvel Raigad, Baharampur, Ambala, Morvi, Fatehpur, Rae Bareli, Khora, Bhusawal, Orai, Bahraich, Vellore, Mahesana, Sambalpur, Raiganj, Sirsa, Danapur, Serampore, Sultan Pur Majra, Guna, Jaunpur, Panvel, Shivpuri, Surendranagar Dudhrej, Unnao, Hugli and Chinsurah, Alappuzha, Kottayam, Machilipatnam, Shimla, Adoni, Tenali, Proddatur, Saharsa, Hindupur, Sasaram, Hajipur, Bhimavaram, Dehri, Madanapalle, Siwan, Bettiah, Guntakal, Srikakulam, Motihari, Dharmavaram, Gudivada, Narasaraopet, Bagaha, Miryalaguda, Tadipatri, Kishanganj, Karaikudi, Suryapet, Jamalpur, Kavali, Tadepalligudem, Amaravati, Buxar, Jehanabad, Aurangabad.
