IgVH Mutation Detection Screening Test
Short Name: IgVH Mutation Screening
Also known as: IgVH Gene Mutation Test, Immunoglobulin Variable Heavy Chain Mutation Test
IgVH Mutation Detection Screening Test test available at DNA Labs India for ₹10,000. Uses PCR, Sequencing on 4 mL (2 mL min.) whole blood in 1 Lavender top (EDTA) tube. samples. Results in Results are typically available within 5 working days after sample collection.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The purpose of the IgVH Mutation Detection Screening Test is to determine the mutation status of IgVH genes in individuals suspected of having B-cell Chronic Lymphocytic Leukemia (B-CLL). This information aids in assessing disease aggressiveness, estimating prognosis, and guiding therapeutic interventions. By identifying whether the IgVH genes are mutated or unmutated, healthcare providers can personalize treatment plans, monitor disease progression, and optimize patient outcomes.
- Test Code
- 859
- Price
- ₹10,000
- Sample Type
- 4 mL (2 mL min.) whole blood in 1 Lavender top (EDTA) tube.
- Result Time
- Results are typically available within 5 working days after sample collection.
- Fasting Required
- No
- Method
- PCR, Sequencing
Sample Collection
No special preparation is required. Inform your healthcare provider about any medications, supplements, or health conditions before the test.
Method: Venipuncture
Laboratory Analysis
A blood sample will be drawn from a vein in your arm by a trained phlebotomist. The procedure is quick, typically taking a few minutes, and may cause minor discomfort.
Report Delivery
Apply gentle pressure to the puncture site to prevent bleeding. You can resume normal activities immediately unless advised otherwise.
Timeline: Results are typically available within 5 working days after sample collection.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of the IgVH Mutation Detection Screening Test is to determine the mutation status of IgVH genes in individuals suspected of having B-cell Chronic Lymphocytic Leukemia (B-CLL). This information aids in assessing disease aggressiveness, estimating prognosis, and guiding therapeutic interventions. By identifying whether the IgVH genes are mutated or unmutated, healthcare providers can personalize treatment plans, monitor disease progression, and optimize patient outcomes.
How to Prepare
- Stay hydrated by drinking water before sample collection
- Avoid strenuous exercise immediately before the test
- Ensure the sample is collected in the specified EDTA tube and labeled correctly
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"This test is essential for prognostic assessment in B-CLL, helping to differentiate between aggressive and indolent forms, thereby guiding personalized treatment plans."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Insufficient sample volume (less than 2 mL)
- Hemolyzed or lipemic sample
- Improperly labeled or contaminated sample
Understanding Your Results
Indicates a less aggressive form of B-CLL with a better prognosis and slower disease progression, often requiring less intensive treatment.
Status: Mutated (>2% mutation)
Indicates a more aggressive form of B-CLL with a poorer prognosis and faster disease progression, typically necessitating closer monitoring and more aggressive therapy.
Status: Unmutated (<2% mutation)
Consult your doctor if you experience symptoms such as persistent fatigue, unexplained weight loss, enlarged lymph nodes, or night sweats. Follow up with your healthcare provider to discuss test results and appropriate treatment options.
Limitations
- ⚠This test is a screening tool and may require confirmatory testing
- ⚠It focuses solely on IgVH mutation status and does not provide comprehensive genetic profiling
- ⚠Results can vary based on laboratory techniques and sample integrity
Risks & Considerations
- ●Minor pain or bruising at the blood draw site
- ●Rare risk of infection or hematoma
- ●No significant long-term risks associated with the test
Interfering Factors
- ●Hemolyzed or clotted blood samples
- ●Contamination during sample collection or processing
- ●Improper storage conditions (e.g., freezing when not allowed)
Compare With Similar Tests
| Test | IgVH Mutation Detection Screening Test | Flow Cytometry | FISH (Fluorescence In Situ Hybridization) |
|---|---|---|---|
| Comparison | IgVH Mutation Detection Screening Test | Complementary to IgVH test for comprehensive B-CLL diagnosis | Provides additional genetic prognostic information beyond IgVH mutation status |
Frequently Asked Questions
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We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
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