Kardiogen Polygenic Risk Score Test
Coronary Artery Disease (CAD) is the most common form of heart disease, triggered when plaque builds up and restricts oxygenated blood flow to the heart. Because CAD develops silently over decades, relying solely on traditional checkups means you might only catch a vulnerability after an adverse cardiac event occurs. The Kardiogen Polygenic Risk Score Test (CAD-PRS) shifts the paradigm from reactive treatment to proactive prevention.
This advanced genomic tool is designed for healthy individuals seeking a comprehensive blueprint for their long-term wellness, lifestyle, and financial planning. While rare monogenic disorders stem from a single broken gene, common conditions like heart disease are multi-factorial and polygenic—meaning they are influenced by thousands of minor genetic variations working in tandem. The Kardiogen test extracts DNA from a routine blood sample to compute your unique Kardiogen Risk Score (KRS), translating complex genetic data into an actionable risk category.
By benchmarking your results against a validated South Asian study population, this test reveals your relative statistical likelihood (odds ratio) of developing CAD compared to the general population. Whether you land in the Average, Moderate, or High risk zone, the findings empower you and your cardiologist to craft an aggressive, personalized roadmap spanning medical management, optimized nutrition, and targeted exercise routines.
🔬 Key Features
📋 Technical Specifications
| Test Classification | Preventive Genetic Screening Assessment (Non-Diagnostic) |
|---|---|
| Primary Target Condition | Coronary Artery Disease (CAD) |
| Genetic Markers Analyzed | Over 1.29 million relevant SNP markers |
| Core Methodology | Array-based Whole Genome Genotyping & Custom Bioinformatics QC Pipeline |
| Laboratory Standards | Whole genome genotyping performed in an ISO-certified laboratory following stringent quality management and testing standards. |
| Statistical Base Comparison | South Asian Study Population (DNA Labs India study cohort) |
| Key Output Metrics | Kardiogen Risk Score (KRS), Decile Bin Placement (1–10), Population Odds-Ratio |
| Test Price | ₹20,000 (all‑inclusive) |
|---|---|
| Sample Type | EDTA Blood Sample |
| Sample Collection | Free across 300+ Indian cities |
| Turnaround Time | 3-4 Weeks |
| Counseling | Complimentary pre‑ & post‑test genetic counseling |
❤️ Benefits
- Prevent Hospitalizations: Forewarned is forearmed; uncover hidden genetic risks early to avoid preventable hospital check-ins and catastrophic health crises.
- Unlock High-Value Statin Utility: Individuals in high genetic risk categories achieve up to a 48% reduction in 10-year relative risk with directed lipid-lowering therapies.
- Counteract Your DNA with Lifestyle: Maintaining optimal habits can slash 10-year complication risks by up to 46% even with high-risk genes.
- Actionable Nutrition Redirection: Receive dietary guardrails synchronized with American Heart Association (AHA) guidelines to eliminate processed hazards.
- Precision Workout Structuring: Empirical clarity to design a weekly routine of 150 to 300 minutes of optimal, heart-protective physical activity.
❓ Frequently Asked Questions
A Polygenic Risk Score calculates the combined, overlapping effects of a massive network of minor genetic variations across your genome. Unlike single-gene tests for monogenic conditions, PRS evaluates common, highly integrated conditions where thousands of tiny genetic switches shape your overall physiological susceptibility.
Absolutely not. This is a predictive screening test, not a diagnostic verdict. Scoring in “Average” or “High” risk highlights your baseline genetic probability. Diet, weight, stress, blood pressure, and fitness play massive roles in whether those genes manifest as illness.
Your odds ratio acts as a mathematical multiplier against the population baseline. An “Average” bracket yields an odds ratio ≤ 1.00 (typical risk). A “High” risk bracket yields an odds ratio of 3.08, meaning roughly three times more likely to develop CAD than the population benchmark.
Yes, and you are strongly urged to do so. While your genetic score cannot be altered, clinical risk factors (LDL cholesterol, blood pressure) are highly malleable via medical interventions, statins, and lifestyle modifications curated by a cardiologist.
This is a standout attribute. The Kardiogen algorithm is thoroughly optimized and validated using DNA Labs India’s South Asian study cohort, ensuring predictive metrics are highly relevant to South Asian genetic architectures.
The Kardiogen Polygenic Risk Score Test is an advanced preventive genome-wide screening product designed to assess inherited risk for Coronary Artery Disease (CAD). Built for forward-thinking, healthy individuals who want to proactively mitigate chronic cardiovascular issues before symptoms surface. By analyzing 1.29 million specific genetic markers, it bridges the diagnostic gap, mapping genetic susceptibilities alongside lifestyle variables. Its unique high-tier scientific pedigree implements a multi-ancestry analytical framework pioneered by Harvard Medical School and features direct statistical validation for South Asian cohorts, delivering localized data accuracy that standard genetic tests lack.