KIR Genotyping Test in India | NK Cell Receptor Analysis & Cost
Comprehensive KIR Gene Typing for Immune System Evaluation
KIR (Killer cell immunoglobulin-like receptor) genotyping identifies the genetic variants of KIRs, which are proteins found on natural killer (NK) cells that play a vital role in the immune system’s response. This testing may be considered for individuals in specific clinical situations:
Reproductive Health and Pregnancy Issues
KIR genotyping, often performed alongside HLA-C testing, can be useful for:
Assessing the risk of the maternal immune system rejecting an embryo. This involves evaluating the interaction between the mother’s KIR receptors and the HLA-C molecules on fetal cells during implantation.
Investigating the causes of infertility, particularly when immune factors are suspected.
Diagnosing the reasons behind recurrent or habitual miscarriages. Studies suggest that an elevated number of activating KIR genes (certain genotypes like Bx) might contribute to recurrent miscarriage.
Understanding potential reasons for failed In Vitro Fertilization (IVF) attempts.
Testing can be performed on the couple, and in cases of gamete donation, the donor’s HLA-C genotype is also required2. The test can be done during pregnancy after consulting a doctor.
Transplantation (Stem Cell/Bone Marrow)
KIR genotyping is used in the context of transplantation, particularly hematopoietic stem cell (bone marrow) transplants:
To aid in the selection of optimal stem cell donors.
To help predict the success of the transplant.
To assess the risk of complications like graft-versus-host disease (GvHD).
KIR matching or mismatching between donor and recipient can influence the graft-versus-leukemia effect, where the donor cells help fight residual cancer cells.
It provides additional information beyond HLA typing about how the recipient’s immune system might interact with the transplanted cells.
Immune System Evaluation and Disease Susceptibility
KIR genotyping may be considered for:
Individuals interested in understanding their immune system’s genetic makeup, including its strengths and weaknesses.
People experiencing symptoms potentially related to immune system function.
Evaluating potential genetic susceptibility to certain conditions, although research is ongoing:
Cancers, as NK cells recognize and attack cancer cells.
Infectious diseases, like HIV or hepatitis, as KIR genotype can affect NK cell response to infected cells.
Autoimmune diseases, such as rheumatoid arthritis, lupus, scleroderma, or type 1 diabetes.
Hematological disorders like acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), aplastic anemia (AA), and myelodysplastic syndromes (MDS).
Consultation with a doctor, immunologist, or specialist (like a hematologist or reproductive specialist) is recommended to determine if KIR genotyping is appropriate for an individual’s specific situation.
Accurate KIR genotyping at ₹13,000 | ASHI-accredited testing | Free home sample collection
Why KIR Genotyping Matters?
Killer Immunoglobulin-like Receptors (KIR) on natural killer (NK) cells regulate immune responses critical for:
- ✅ Pregnancy maintenance and placental development
- ✅ Cancer cell surveillance
- ✅ Viral infection resistance
- ✅ Bone marrow transplantation success
Who Needs KIR Testing?
Critical Applications
Recurrent Pregnancy Loss
Identify AA/Bx haplotype combinations linked to 3x higher miscarriage risk
Transplant Medicine
Essential for donor-recipient matching in haploidentical BMT
Autoimmune Disorders
Assess KIR-HLA interactions in rheumatoid arthritis/Lupus patients
Our Advanced Testing Protocol
Gold-Standard Methodology
| Parameter | Details |
|---|---|
| Technology | Luminex SSO with Illumina MiSeq verification |
| Genes Analyzed | 16 KIR genes including 2DL1-5, 3DL1-3, 2DS1-5 |
| Turnaround Time | 2 working days from sample receipt |
Sample Collection Made Simple
- Book online – Get phlebotomist dispatch confirmation
- Home collection – 6mL blood in EDTA/ACD tube
- Express shipping to NABL-certified lab
Understanding Your Report
Key Components Analyzed
Haplotype Determination: AA vs Bx genotypes
Activating/Inhibitory Ratio: 2DS4 vs 3DL1 balance
Pseudogene Markers: 2DP1 & 3DP1 verification
Why Choose DNA Labs India?
ASHI Accreditation
03-1-NY-26-2 certified testing
Pan-India Service
Available in 200+ cities including Mumbai, Delhi, Bengaluru
Expert Consultation
Free post-report counseling with immunologists
Test Cost & Booking
₹18,000
₹13,000 (28% OFF)
EMI options available | Corporate discounts
Coverage Areas
Service available in all major cities: Mumbai, Delhi, Bengaluru, Hyderabad, Chennai, Kolkata, Pune, Ahmedabad, Jaipur, Lucknow, Kochi, and 190+ other locations.
FAQs: KIR Genotyping
Q: How does KIR affect pregnancy?
A: Maternal AA genotype with fetal HLA-C2 increases miscarriage risk 4.7x
Q: Test preparation needed?
A: No fasting required – simple blood draw
Q: Interpretation support?
A: Free teleconsultation with report
Recent Advancements in KIR Research
2024 studies show KIR2DS2 activation reduces leukemia relapse by 38% post-transplant
| Test Name | KIR Genotyping Test |
|---|---|
| Sample type | 4 mL (3 mL min.) whole blood in 1 Lavender Top (EDTA) tube OR 6 mL (3 mL min.) whole blood in 1 Yellow Top (ACD) tube. Ship refrigerated. DO NOT FREEZE. |
| Test type | Hematologist |
| Pre-test Information | No special preparation required |
| Disease | Transplantation Pathology |
| Method | Luminex SSO |
| Purpose | NULL |
| Preparation | Room Temperature: NA, Refrigerator:96 hrs, Frozen: NA |
| Fasting | No special preparation required |
| Get Reports | Sample Daily by 9 am; Report 2 Working days |
| Test Price | INR ₹ 13000 |
Note: We offer free home sample collection for online bookings for KIR Genotyping Test and the test costs a special discounted price of 13000 INR across India. The cities where this service is available include Mumbai, Delhi, Bangalore, Hyderabad, Ahmedabad, Chennai, Kolkata, Surat, Pune, Jaipur, Lucknow, Kanpur, Nagpur, Indore, Thane, Bhopal, Visakhapatnam, Pimpri-Chinchwad, Patna, Vadodara, Ghaziabad, Ludhiana, Agra, Nashik, Faridabad, Meerut, Rajkot, Kalyan-Dombivali, Vasai-Virar, Varanasi, Srinagar, Aurangabad, Dhanbad, Amritsar, Navi Mumbai, Prayagraj, Howrah, Ranchi, Jabalpur, Gwalior, Coimbatore, Vijayawada, Jodhpur, Madurai, Raipur, Kota, Guwahati, Chandigarh, Thiruvananthapuram, Solapur, Hubballi-Dharwad, Tiruchirappalli, Tiruppur, Moradabad, Mysore, Bareily, Gurgaon, Aligarh, Jalandhar, Bhubaneswar, Salem, Mira-Bhayandar, Warangal , Guntur , Bhiwandi, Saharanpur, Gorakhpur, Bikaner, Amravati, Noida, Jamshedpur, Bhilai, Cuttack, Firozabad, Kochi, Nellore , Bhavnagar, Dehradun, Durgapur, Asansol, Rourkela, Nanded, Kolhapur, Ajmer, Akola, Gulbarga, Jamnagar, Ujjain, Loni, Siliguri, Jhansi, Ulhasnagar, Jammu, Sangli-Miraj & Kupwad, Mangalore, Erode10, Belgaum, Ambattur, Tirunelveli, Malegaon, Gaya, Jalgaon, Udaipur, Maheshtala, Davanagere, Kozhikode, Kurnool, Rajpur Sonarpur, Rajahmundry , Bokaro, South Dumdum, Bellary, Patiala, Gopalpur, Agartala, Bhagalpur, Muzaffarnagar, Bhatpara, Panihati, Latur, Dhule, Tirupati , Rohtak, Korba, Bhilwara, Berhampur, Muzaffarpur, Ahmednagar, Mathura, Kollam, Avadi, Kadapa, Kamarhati, Sambalpur, Bilaspur, Shahjahanpur, Satara, Bijapur, Rampur, Shivamogga, Chandrapur, Junagadh, Thrissur, Alwar, Bardhaman, Kulti, Kakinada, Nizamabad, Parbhani, Tumkur, Khammam, Ozhukarai, Bihar Sharif, Panipat, Darbhanga, Bally, Aizawl, Dewas, Ichalkaranji, Karnal, Bathinda, Jalna, Eluru, Kirari Suleman Nagar, Barasat, Purnia, Satna, Mau, Sonipat, Farrukhabad, Sagar, Rourkela, Durg, Imphal, Ratlam, Hapur, Arrah, Karimnagar, Anantapur, Etawah, Ambernath, North Dumdum, Bharatpur, Begusarai, New Delhi, Gandhidham, Baranagar, Tiruvottiyur, Puducherry, Sikar, Thoothukudi, Rewa, Mirzapur, Raichur, Pali, Ramagundam , Haridwar, Vijayanagaram, Katihar, Nagarcoil, Sri Ganganagar, Karawal Nagar, Mango, Thanjavur, Bulandshahr, Uluberia, Murwara, Sambhal, Singrauli, Nadiad, Secunderabad, Naihati, Yamunanagar, Bidhan Nagar, Pallavaram, Bidar, Munger, Panchkula, Burhanpur, Raurkela Industrial Township, Kharagpur, Dindigul, Gandhinagar, Hospet, Nangloi Jat, Malda, Ongole, Deoghar, Chapra, Haldia, Khandwa, Nandyal, Chittoor , Morena, Amroha, Anand, Bhind, Bhalswa Jahangir Pur, Madhyamgram, Bhiwani, Navi Mumbai Panvel Raigad, Baharampur, Ambala, Morvi, Fatehpur, Rae Bareli, Khora, Bhusawal, Orai, Bahraich, Vellore, Mahesana, Sambalpur, Raiganj, Sirsa, Danapur, Serampore, Sultan Pur Majra, Guna, Jaunpur, Panvel, Shivpuri, Surendranagar Dudhrej, Unnao, Hugli and Chinsurah, Alappuzha, Kottayam, Machilipatnam, Shimla, Adoni, Tenali, Proddatur, Saharsa, Hindupur, Sasaram, Hajipur, Bhimavaram, Dehri, Madanapalle, Siwan, Bettiah, Guntakal, Srikakulam, Motihari, Dharmavaram, Gudivada, Narasaraopet, Bagaha, Miryalaguda, Tadipatri, Kishanganj, Karaikudi, Suryapet, Jamalpur, Kavali, Tadepalligudem, Amaravati, Buxar, Jehanabad, Aurangabad.
