LEUCOCYTE ADHESION DEFICIENCY (LAD I & II) Test Cost, Symptoms, and Diagnosis

Leucocyte Adhesion Deficiency (LAD) is a rare genetic disorder that affects the immune system. It is caused by mutations in the genes that are responsible for the production of proteins that allow white blood cells (leucocytes) to stick to the walls of blood vessels and move towards sites of infection or injury. This results in a weakened immune system and makes individuals with LAD more susceptible to bacterial infections. There are two types of LAD – LAD I and LAD II. In this blog, we will discuss the symptoms, diagnosis, and cost of the LAD I and II test offered by DNA Labs India.

Symptoms of LAD I and II

The symptoms of LAD I and II are similar and include:

• Frequent bacterial infections, such as pneumonia, meningitis, and skin infections
• Delayed wound healing
• Recurrent abscesses
• Swollen lymph nodes
• Delayed development of teeth

Individuals with LAD II may also experience bleeding from the gums and nose, as well as abnormal bruising and bleeding.

Diagnosis of LAD I and II

The diagnosis of LAD I and II is typically made through a combination of clinical evaluation, blood tests, and genetic testing. The blood tests may include a complete blood count (CBC), which can show a decreased number of white blood cells, and flow cytometry, which can show abnormalities in the white blood cells. Genetic testing can confirm the diagnosis and identify the specific genetic mutation responsible for the disorder.

LAD I and II Test Cost

The LAD I and II test is offered by DNA Labs India and costs INR 5500. The test includes a complete blood count (CBC) and flow cytometry to evaluate the white blood cells, as well as genetic testing to confirm the diagnosis and identify the specific genetic mutation responsible for the disorder.

Conclusion

Leucocyte Adhesion Deficiency (LAD) is a rare genetic disorder that affects the immune system and makes individuals more susceptible to bacterial infections. There are two types of LAD – LAD I and LAD II. The symptoms of LAD I and II are similar and include frequent bacterial infections, delayed wound healing, recurrent abscesses, swollen lymph nodes, and delayed development of teeth. The diagnosis of LAD I and II is typically made through a combination of clinical evaluation, blood tests, and genetic testing. DNA Labs India offers the LAD I and II test for INR 5500, which includes a complete blood count (CBC), flow cytometry, and genetic testing to confirm the diagnosis and identify the specific genetic mutation responsible for the disorder.

If you suspect that you or someone you know may have LAD I or II, it is important to speak with a healthcare provider and consider getting tested. Early diagnosis and treatment can help to prevent serious complications and improve quality of life.

LAD is an autosomal recessive immunodeficiency disorder that affects the leucocyte adhesion process and is associated with recurrent bacterial and fungal infections. Two forms of LAD have been described. LAD-I is associated with defective expression of CD18 by neutrophils resulting from mutations in the integrin beta-2 gene (ITGB2), encoding CD18 of beta-2 integrins. LAD-II is associated with defective expression of CD15s (sialyl-Lewis X) resulting from mutations in the Glucose diphosphate (GDP)-fucose transporter gene. Genetic testing for the ITGB2 gene (associated with LAD-I) is recommended to verify specific mutation and confirm diagnosis while preparing for Hematopoietic Cell Transplantation (HCT).

 Note: We offer free home sample collection for online bookings for Leucocyte Adhesion Deficiency (LAD I & II) Test and the test costs a special discounted price of 5500 INR across India. The cities where this service is available include Mumbai, Delhi, Bangalore, Hyderabad, Ahmedabad, Chennai, Kolkata, Surat, Pune, Jaipur, Lucknow, Kanpur, Nagpur, Indore, Thane, Bhopal, Visakhapatnam, Pimpri-Chinchwad, Patna, Vadodara, Ghaziabad, Ludhiana, Agra, Nashik, Faridabad, Meerut, Rajkot, Kalyan-Dombivali, Vasai-Virar, Varanasi, Srinagar, Aurangabad, Dhanbad, Amritsar, Navi Mumbai, Prayagraj, Howrah, Ranchi, Jabalpur, Gwalior, Coimbatore, Vijayawada, Jodhpur, Madurai, Raipur, Kota, Guwahati, Chandigarh, Thiruvananthapuram, Solapur, Hubballi-Dharwad, Tiruchirappalli, Tiruppur, Moradabad, Mysore, Bareily, Gurgaon, Aligarh, Jalandhar, Bhubaneswar, Salem, Mira-Bhayandar, Warangal , Guntur , Bhiwandi, Saharanpur, Gorakhpur, Bikaner, Amravati, Noida, Jamshedpur, Bhilai, Cuttack, Firozabad, Kochi, Nellore , Bhavnagar, Dehradun, Durgapur, Asansol, Rourkela, Nanded, Kolhapur, Ajmer, Akola, Gulbarga, Jamnagar, Ujjain, Loni, Siliguri, Jhansi, Ulhasnagar, Jammu, Sangli-Miraj & Kupwad, Mangalore, Erode10, Belgaum, Ambattur, Tirunelveli, Malegaon, Gaya, Jalgaon, Udaipur, Maheshtala, Davanagere, Kozhikode, Kurnool, Rajpur Sonarpur, Rajahmundry , Bokaro, South Dumdum, Bellary, Patiala, Gopalpur, Agartala, Bhagalpur, Muzaffarnagar, Bhatpara, Panihati, Latur, Dhule, Tirupati , Rohtak, Korba, Bhilwara, Berhampur, Muzaffarpur, Ahmednagar, Mathura, Kollam, Avadi, Kadapa, Kamarhati, Sambalpur, Bilaspur, Shahjahanpur, Satara, Bijapur, Rampur, Shivamogga, Chandrapur, Junagadh, Thrissur, Alwar, Bardhaman, Kulti, Kakinada, Nizamabad, Parbhani, Tumkur, Khammam, Ozhukarai, Bihar Sharif, Panipat, Darbhanga, Bally, Aizawl, Dewas, Ichalkaranji, Karnal, Bathinda, Jalna, Eluru, Kirari Suleman Nagar, Barasat, Purnia, Satna, Mau, Sonipat, Farrukhabad, Sagar, Rourkela, Durg, Imphal, Ratlam, Hapur, Arrah, Karimnagar, Anantapur, Etawah, Ambernath, North Dumdum, Bharatpur, Begusarai, New Delhi, Gandhidham, Baranagar, Tiruvottiyur, Puducherry, Sikar, Thoothukudi, Rewa, Mirzapur, Raichur, Pali, Ramagundam , Haridwar, Vijayanagaram, Katihar, Nagarcoil, Sri Ganganagar, Karawal Nagar, Mango, Thanjavur, Bulandshahr, Uluberia, Murwara, Sambhal, Singrauli, Nadiad, Secunderabad, Naihati, Yamunanagar, Bidhan Nagar, Pallavaram, Bidar, Munger, Panchkula, Burhanpur, Raurkela Industrial Township, Kharagpur, Dindigul, Gandhinagar, Hospet, Nangloi Jat, Malda, Ongole, Deoghar, Chapra, Haldia, Khandwa, Nandyal, Chittoor , Morena, Amroha, Anand, Bhind, Bhalswa Jahangir Pur, Madhyamgram, Bhiwani, Navi Mumbai Panvel Raigad, Baharampur, Ambala, Morvi, Fatehpur, Rae Bareli, Khora, Bhusawal, Orai, Bahraich, Vellore, Mahesana, Sambalpur, Raiganj, Sirsa, Danapur, Serampore, Sultan Pur Majra, Guna, Jaunpur, Panvel, Shivpuri, Surendranagar Dudhrej, Unnao, Hugli and Chinsurah, Alappuzha, Kottayam, Machilipatnam, Shimla, Adoni, Tenali, Proddatur, Saharsa, Hindupur, Sasaram, Hajipur, Bhimavaram, Dehri, Madanapalle, Siwan, Bettiah, Guntakal, Srikakulam, Motihari, Dharmavaram, Gudivada, Narasaraopet, Bagaha, Miryalaguda, Tadipatri, Kishanganj, Karaikudi, Suryapet, Jamalpur, Kavali, Tadepalligudem, Amaravati, Buxar, Jehanabad, Aurangabad.