NRG1 Gene and Hirschsprung Disease: Understanding Symptoms, Diagnosis, and NGS Genetic Test Cost in India
Genetic testing has become an integral part of diagnosing and treating diseases. With the advent of Next Generation Sequencing (NGS) technology, it is now possible to sequence a large number of genes in a short span of time and at a reasonable cost. One such gene that has gained attention in recent years is the NRG1 gene, which has been linked to Hirschsprung disease.
What is Hirschsprung disease?
Hirschsprung disease is a rare condition that affects the large intestine. It is caused by the absence of nerve cells in the lower part of the intestine, which leads to a blockage. This blockage can cause severe constipation, abdominal pain, and other digestive problems. The condition is usually diagnosed in infancy or early childhood, but in some cases, it may not be diagnosed until adulthood.
What is the NRG1 gene?
The NRG1 gene is located on chromosome 8 and is responsible for producing a protein called neuregulin-1. This protein plays an essential role in the development of the nervous system, including the neurons that control the movement of the digestive tract. Mutations in the NRG1 gene have been linked to Hirschsprung disease.
Symptoms of Hirschsprung disease
The symptoms of Hirschsprung disease vary depending on the severity of the condition. Some of the common symptoms include:
- Chronic constipation
- Abdominal distension
- Difficulty passing stools
- Diarrhea
- Vomiting
- Slow growth
Diagnosis of Hirschsprung disease
The diagnosis of Hirschsprung disease usually involves a combination of physical examination, medical history, and tests. Some of the common tests used to diagnose the condition include:
- Rectal biopsy: A small sample of tissue is taken from the rectum and examined under a microscope to look for the absence of nerve cells.
- Barium enema: A contrast material is inserted into the rectum, and X-rays are taken to look for any blockages in the large intestine.
- Anorectal manometry: A small tube is inserted into the rectum to measure the pressure and function of the muscles in the anus and rectum.
NGS Genetic Test Cost in India
The cost of NGS Genetic Testing in India varies depending on the laboratory and the number of genes sequenced. The cost of sequencing the NRG1 gene for Hirschsprung disease is approximately INR 20,000. However, the cost may vary depending on the laboratory and the type of test performed.
Conclusion
Hirschsprung disease is a rare condition that can cause severe digestive problems. The NRG1 gene has been linked to the condition, and NGS Genetic Testing can help diagnose the condition early. The cost of sequencing the NRG1 gene for Hirschsprung disease is approximately INR 20,000, making it an affordable option for those who suspect they may have the condition.
At DNA Labs India, we provide NGS Genetic Testing for a wide range of conditions, including Hirschsprung disease. Contact us today to learn more about our services and how we can help you.
Before getting tested ask for Raw Data, FASTQ, and VCF files along with clinical test report from DNA Testing Lab. DNA Labs India is the Only lab that is transparent and will share Raw Data, FASTQ, and VCF files along with the conclusive clinical report for NRG1 Gene Hirschsprung disease NGS Genetic Test
| Test Name | NRG1 Gene Hirschsprung disease NGS Genetic Test |
|---|---|
| Sample type | Blood or Extracted DNA or One drop Blood on FTA Card |
| Test type | Pediatrics |
| Pre-test Information | Clinical History of Patient who is going for NRG1 Gene Hirschsprung disease NGS Genetic Test. A Genetic Counselling session to draw a pedigree chart of family members affected with NRG1 Gene Hirschsprung disease NGS Genetic Test gene NRG1 |
| Disease | Dysmorphology |
| Method | NGS Technology |
| Purpose | NULL |
| Preparation | Ambient Room Temperature |
| Fasting | Clinical History of Patient who is going for NRG1 Gene Hirschsprung disease NGS Genetic Test. A Genetic Counselling session to draw a pedigree chart of family members affected with NRG1 Gene Hirschsprung disease NGS Genetic Test gene NRG1 |
| Get Reports | 3 to 4 Weeks |
| Test Price | INR ₹ 20000 |
Note: We offer free home sample collection for online bookings for NRG1 Gene Hirschsprung disease NGS Genetic Test and the test costs a special discounted price of 20000 INR across India. The cities where this service is available include Mumbai, Delhi, Bangalore, Hyderabad, Ahmedabad, Chennai, Kolkata, Surat, Pune, Jaipur, Lucknow, Kanpur, Nagpur, Indore, Thane, Bhopal, Visakhapatnam, Pimpri-Chinchwad, Patna, Vadodara, Ghaziabad, Ludhiana, Agra, Nashik, Faridabad, Meerut, Rajkot, Kalyan-Dombivali, Vasai-Virar, Varanasi, Srinagar, Aurangabad, Dhanbad, Amritsar, Navi Mumbai, Prayagraj, Howrah, Ranchi, Jabalpur, Gwalior, Coimbatore, Vijayawada, Jodhpur, Madurai, Raipur, Kota, Guwahati, Chandigarh, Thiruvananthapuram, Solapur, Hubballi-Dharwad, Tiruchirappalli, Tiruppur, Moradabad, Mysore, Bareily, Gurgaon, Aligarh, Jalandhar, Bhubaneswar, Salem, Mira-Bhayandar, Warangal , Guntur , Bhiwandi, Saharanpur, Gorakhpur, Bikaner, Amravati, Noida, Jamshedpur, Bhilai, Cuttack, Firozabad, Kochi, Nellore , Bhavnagar, Dehradun, Durgapur, Asansol, Rourkela, Nanded, Kolhapur, Ajmer, Akola, Gulbarga, Jamnagar, Ujjain, Loni, Siliguri, Jhansi, Ulhasnagar, Jammu, Sangli-Miraj & Kupwad, Mangalore, Erode10, Belgaum, Ambattur, Tirunelveli, Malegaon, Gaya, Jalgaon, Udaipur, Maheshtala, Davanagere, Kozhikode, Kurnool, Rajpur Sonarpur, Rajahmundry , Bokaro, South Dumdum, Bellary, Patiala, Gopalpur, Agartala, Bhagalpur, Muzaffarnagar, Bhatpara, Panihati, Latur, Dhule, Tirupati , Rohtak, Korba, Bhilwara, Berhampur, Muzaffarpur, Ahmednagar, Mathura, Kollam, Avadi, Kadapa, Kamarhati, Sambalpur, Bilaspur, Shahjahanpur, Satara, Bijapur, Rampur, Shivamogga, Chandrapur, Junagadh, Thrissur, Alwar, Bardhaman, Kulti, Kakinada, Nizamabad, Parbhani, Tumkur, Khammam, Ozhukarai, Bihar Sharif, Panipat, Darbhanga, Bally, Aizawl, Dewas, Ichalkaranji, Karnal, Bathinda, Jalna, Eluru, Kirari Suleman Nagar, Barasat, Purnia, Satna, Mau, Sonipat, Farrukhabad, Sagar, Rourkela, Durg, Imphal, Ratlam, Hapur, Arrah, Karimnagar, Anantapur, Etawah, Ambernath, North Dumdum, Bharatpur, Begusarai, New Delhi, Gandhidham, Baranagar, Tiruvottiyur, Puducherry, Sikar, Thoothukudi, Rewa, Mirzapur, Raichur, Pali, Ramagundam , Haridwar, Vijayanagaram, Katihar, Nagarcoil, Sri Ganganagar, Karawal Nagar, Mango, Thanjavur, Bulandshahr, Uluberia, Murwara, Sambhal, Singrauli, Nadiad, Secunderabad, Naihati, Yamunanagar, Bidhan Nagar, Pallavaram, Bidar, Munger, Panchkula, Burhanpur, Raurkela Industrial Township, Kharagpur, Dindigul, Gandhinagar, Hospet, Nangloi Jat, Malda, Ongole, Deoghar, Chapra, Haldia, Khandwa, Nandyal, Chittoor , Morena, Amroha, Anand, Bhind, Bhalswa Jahangir Pur, Madhyamgram, Bhiwani, Navi Mumbai Panvel Raigad, Baharampur, Ambala, Morvi, Fatehpur, Rae Bareli, Khora, Bhusawal, Orai, Bahraich, Vellore, Mahesana, Sambalpur, Raiganj, Sirsa, Danapur, Serampore, Sultan Pur Majra, Guna, Jaunpur, Panvel, Shivpuri, Surendranagar Dudhrej, Unnao, Hugli and Chinsurah, Alappuzha, Kottayam, Machilipatnam, Shimla, Adoni, Tenali, Proddatur, Saharsa, Hindupur, Sasaram, Hajipur, Bhimavaram, Dehri, Madanapalle, Siwan, Bettiah, Guntakal, Srikakulam, Motihari, Dharmavaram, Gudivada, Narasaraopet, Bagaha, Miryalaguda, Tadipatri, Kishanganj, Karaikudi, Suryapet, Jamalpur, Kavali, Tadepalligudem, Amaravati, Buxar, Jehanabad, Aurangabad.
