PML RARA t(1517)(q22q12) Gene Rearrangement Quantitative MRD Monitor Test
Short Name: PML-RARA MRD Monitor
Also known as: PML-RARA Fusion Gene Test, t(15;17) MRD Monitoring, APL MRD Test
PML RARA t(1517)(q22q12) Gene Rearrangement Quantitative MRD Monitor Test test available at DNA Labs India for ₹6,084. Uses Real Time PCR on Whole Blood or Bone Marrow samples. Results in Samples are processed on Monday, Wednesday, and Friday. Reports are generally delivered within 1-2 days after sample receipt.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
The purpose of this test is to quantitatively measure the PML-RARA fusion transcript levels in patients with Acute Promyelocytic Leukemia (APL). It is used to monitor measurable residual disease (MRD), evaluate the effectiveness of therapy, and detect early molecular relapse. Serial monitoring of the fusion transcript helps clinicians make informed decisions about continuing, changing, or adjusting treatment protocols.
- Test Code
- 3559
- ICD Code
- C92.4
- Price
- ₹6,084
- Sample Type
- Whole Blood or Bone Marrow
- Result Time
- Samples are processed on Monday, Wednesday, and Friday. Reports are generally delivered within 1-2 days after sample receipt.
- Fasting Required
- No
- Method
- Real Time PCR
Sample Collection
Ensure the MRD requisition form (Form 22) is duly filled with historical data. No fasting is required. Inform your physician about any current medications or treatments.
Method: Venipuncture or Bone Marrow Aspiration
Laboratory Analysis
A blood sample will be collected from a vein in your arm using a sterile needle. For bone marrow aspiration, you will be given local anesthesia and the sample will be drawn from the hip bone by a trained specialist.
Report Delivery
Apply gentle pressure to the venipuncture site to prevent bruising. If you underwent bone marrow aspiration, rest for a few minutes and follow the site care instructions given by the clinician.
Timeline: Samples are processed on Monday, Wednesday, and Friday. Reports are generally delivered within 1-2 days after sample receipt.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of this test is to quantitatively measure the PML-RARA fusion transcript levels in patients with Acute Promyelocytic Leukemia (APL). It is used to monitor measurable residual disease (MRD), evaluate the effectiveness of therapy, and detect early molecular relapse. Serial monitoring of the fusion transcript helps clinicians make informed decisions about continuing, changing, or adjusting treatment protocols.
How to Prepare
- Ship the sample refrigerated at 2-8°C
- Do not freeze the sample
- Use a Lavender Top (EDTA) tube
- Attach the duly filled MRD requisition form (Form 22) with historical data
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"Monitoring PML-RARA transcript levels is essential for timely intervention in APL patients. This quantitative MRD test provides precise data to guide therapy decisions."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Samples received without the completed MRD requisition form
- Hemolyzed, clotted, or frozen samples
- Sample volume less than 3 mL
- Samples not refrigerated or delayed beyond 72 hours
Understanding Your Results
Negative
No PML-RARA fusion transcript detected. Indicates absence of measurable residual disease (MRD negative).
Positive (low level)
LOW level of PML-RARA transcripts detected. May require close monitoring and consideration of preemptive therapy.
Positive (rising level)
Rising transcript levels suggest molecular relapse; prompt clinical evaluation and intervention are needed.
Consult your oncologist or hematologist if you have been diagnosed with APL and are due for a follow-up MRD assessment, or if you experience symptoms such as unexplained fever, fatigue, easy bruising, bleeding, or shortness of breath.
Limitations
- ⚠Test is specific to the t(15;17) PML-RARA fusion; other rare variant translocations may not be detected
- ⚠Quantification may not be reliable at very low transcript levels near the limit of detection
- ⚠Results should be interpreted in conjunction with clinical findings and other diagnostic tests
Risks & Considerations
- ●Mild pain or bruising at the venipuncture site
- ●Infection or bleeding at the bone marrow aspiration site (rare)
- ●Fainting or dizziness during blood collection
Interfering Factors
- ●Poor RNA quality due to delayed sample processing
- ●Sample hemolysis or clot formation
- ●Inhibitors in the sample affecting PCR amplification
- ●Sample subjected to freezing instead of refrigerated storage
Compare With Similar Tests
| Test | PML RARA t(1517)(q22q12) Gene Rearrangement Quantitative MRD Monitor Test | Flow Cytometry MRD Panel | BCR-ABL Quantitative MRD | Cytogenetic Analysis |
|---|---|---|---|---|
| Comparison | PML RARA t(1517)(q22q12) Gene Rearrangement Quantitative MRD Monitor Test |
Frequently Asked Questions
What is the PML RARA t(15;17) gene rearrangement?
Why is the PML RARA quantitative MRD monitor test done?
What is the sample type required for this test?
Do I need to fast before the test?
How is the test performed?
How long does it take to get results?
What does a negative result mean?
What does a positive result indicate?
Is home sample collection available?
What is the cost of the test?
Are there any risks associated with the test?
Can this test be used for initial diagnosis of APL?
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