Understanding RET Gene and Hirschsprung Disease: NGS Genetic Test Cost in India

Hirschsprung disease is a rare genetic disorder that affects the large intestine or colon. It is caused by a mutation in the RET gene, which is responsible for the development of the enteric nervous system, a complex network of nerves that controls the movement of the digestive tract. Hirschsprung disease is characterized by an absence of ganglion cells in the colon, which results in chronic constipation, abdominal distension, and other symptoms.

Symptoms of Hirschsprung Disease

The symptoms of Hirschsprung disease usually appear shortly after birth, although some children may not show any signs until later in life. The most common symptoms of Hirschsprung disease include:

• Chronic constipation
• Abdominal distension or swelling
• Vomiting
• Poor appetite or feeding difficulties
• Delayed growth or failure to thrive
• Diarrhea or foul-smelling stools
• Rectal prolapse or the protrusion of the rectum through the anus

If left untreated, Hirschsprung disease can cause serious complications, such as enterocolitis, a life-threatening inflammation of the intestines, and bowel obstruction, which requires emergency medical treatment.

Diagnosis of Hirschsprung Disease

Diagnosing Hirschsprung disease can be challenging, as the symptoms can be similar to other digestive disorders, such as irritable bowel syndrome or inflammatory bowel disease. In most cases, the diagnosis is made based on a combination of clinical history, physical examination, and specialized tests, such as:

• Anorectal manometry, which measures the pressure in the rectum and anus
• Barium enema, which involves the use of a contrast material to visualize the colon on an X-ray
• Rectal biopsy, which involves the removal of a small tissue sample from the rectum for examination under a microscope

NGS Genetic Test for Hirschsprung Disease

Next-generation sequencing (NGS) is a powerful genetic testing technology that can identify mutations in the RET gene associated with Hirschsprung disease. NGS can analyze multiple genes simultaneously, providing a comprehensive picture of an individual’s genetic makeup and the risk of developing Hirschsprung disease or other genetic disorders.

The cost of NGS Genetic Testing for Hirschsprung disease in India varies depending on the provider and the specific test ordered. However, on average, the cost of NGS Genetic Testing for Hirschsprung disease ranges from INR 15,000 to INR 25,000.

Conclusion

Hirschsprung disease is a rare genetic disorder that can cause chronic constipation, abdominal distension, and other symptoms. NGS Genetic Testing can identify mutations in the RET gene associated with Hirschsprung disease, providing an accurate diagnosis and personalized treatment plan. If you or your child is experiencing symptoms of Hirschsprung disease, it is essential to seek medical attention promptly and consider genetic testing to determine the underlying cause of the condition.

At DNA Labs India, we offer advanced NGS Genetic Testing for Hirschsprung disease and other genetic disorders. Contact us today to learn more about our services and how we can help you.

 Note: We offer free home sample collection for online bookings for RET Gene Hirschsprung disease NGS Genetic Test and the test costs a special discounted price of 20000 INR across India. The cities where this service is available include Mumbai, Delhi, Bangalore, Hyderabad, Ahmedabad, Chennai, Kolkata, Surat, Pune, Jaipur, Lucknow, Kanpur, Nagpur, Indore, Thane, Bhopal, Visakhapatnam, Pimpri-Chinchwad, Patna, Vadodara, Ghaziabad, Ludhiana, Agra, Nashik, Faridabad, Meerut, Rajkot, Kalyan-Dombivali, Vasai-Virar, Varanasi, Srinagar, Aurangabad, Dhanbad, Amritsar, Navi Mumbai, Prayagraj, Howrah, Ranchi, Jabalpur, Gwalior, Coimbatore, Vijayawada, Jodhpur, Madurai, Raipur, Kota, Guwahati, Chandigarh, Thiruvananthapuram, Solapur, Hubballi-Dharwad, Tiruchirappalli, Tiruppur, Moradabad, Mysore, Bareily, Gurgaon, Aligarh, Jalandhar, Bhubaneswar, Salem, Mira-Bhayandar, Warangal , Guntur , Bhiwandi, Saharanpur, Gorakhpur, Bikaner, Amravati, Noida, Jamshedpur, Bhilai, Cuttack, Firozabad, Kochi, Nellore , Bhavnagar, Dehradun, Durgapur, Asansol, Rourkela, Nanded, Kolhapur, Ajmer, Akola, Gulbarga, Jamnagar, Ujjain, Loni, Siliguri, Jhansi, Ulhasnagar, Jammu, Sangli-Miraj & Kupwad, Mangalore, Erode10, Belgaum, Ambattur, Tirunelveli, Malegaon, Gaya, Jalgaon, Udaipur, Maheshtala, Davanagere, Kozhikode, Kurnool, Rajpur Sonarpur, Rajahmundry , Bokaro, South Dumdum, Bellary, Patiala, Gopalpur, Agartala, Bhagalpur, Muzaffarnagar, Bhatpara, Panihati, Latur, Dhule, Tirupati , Rohtak, Korba, Bhilwara, Berhampur, Muzaffarpur, Ahmednagar, Mathura, Kollam, Avadi, Kadapa, Kamarhati, Sambalpur, Bilaspur, Shahjahanpur, Satara, Bijapur, Rampur, Shivamogga, Chandrapur, Junagadh, Thrissur, Alwar, Bardhaman, Kulti, Kakinada, Nizamabad, Parbhani, Tumkur, Khammam, Ozhukarai, Bihar Sharif, Panipat, Darbhanga, Bally, Aizawl, Dewas, Ichalkaranji, Karnal, Bathinda, Jalna, Eluru, Kirari Suleman Nagar, Barasat, Purnia, Satna, Mau, Sonipat, Farrukhabad, Sagar, Rourkela, Durg, Imphal, Ratlam, Hapur, Arrah, Karimnagar, Anantapur, Etawah, Ambernath, North Dumdum, Bharatpur, Begusarai, New Delhi, Gandhidham, Baranagar, Tiruvottiyur, Puducherry, Sikar, Thoothukudi, Rewa, Mirzapur, Raichur, Pali, Ramagundam , Haridwar, Vijayanagaram, Katihar, Nagarcoil, Sri Ganganagar, Karawal Nagar, Mango, Thanjavur, Bulandshahr, Uluberia, Murwara, Sambhal, Singrauli, Nadiad, Secunderabad, Naihati, Yamunanagar, Bidhan Nagar, Pallavaram, Bidar, Munger, Panchkula, Burhanpur, Raurkela Industrial Township, Kharagpur, Dindigul, Gandhinagar, Hospet, Nangloi Jat, Malda, Ongole, Deoghar, Chapra, Haldia, Khandwa, Nandyal, Chittoor , Morena, Amroha, Anand, Bhind, Bhalswa Jahangir Pur, Madhyamgram, Bhiwani, Navi Mumbai Panvel Raigad, Baharampur, Ambala, Morvi, Fatehpur, Rae Bareli, Khora, Bhusawal, Orai, Bahraich, Vellore, Mahesana, Sambalpur, Raiganj, Sirsa, Danapur, Serampore, Sultan Pur Majra, Guna, Jaunpur, Panvel, Shivpuri, Surendranagar Dudhrej, Unnao, Hugli and Chinsurah, Alappuzha, Kottayam, Machilipatnam, Shimla, Adoni, Tenali, Proddatur, Saharsa, Hindupur, Sasaram, Hajipur, Bhimavaram, Dehri, Madanapalle, Siwan, Bettiah, Guntakal, Srikakulam, Motihari, Dharmavaram, Gudivada, Narasaraopet, Bagaha, Miryalaguda, Tadipatri, Kishanganj, Karaikudi, Suryapet, Jamalpur, Kavali, Tadepalligudem, Amaravati, Buxar, Jehanabad, Aurangabad.