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Tissue Transglutaminase TTG-DGP Screen Test

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Tissue Transglutaminase TTG-DGP Screen Test

Short Name: TTG-DGP Screen

Also known as: TTG-DGP Screen, Celiac Disease Screen, Deamidated Gliadin Peptide and Tissue Transglutaminase Antibodies

Tissue Transglutaminase TTG-DGP Screen Test test available at DNA Labs India for ₹2,223. Uses Enzyme Immunoassay (EIA), ELISA on Serum samples. Results in Reports are typically available the same day if the sample reaches the lab by 9 am. Otherwise, reports are delivered within 24 hours.. Free home collection in 300+ cities across India.

Enzyme Immunoassay🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr Pasupathy Arumugam

Dr Pasupathy Arumugam

Consultant Pathologist · Reg: 21521

Last reviewed: September 7, 2026

Overview

The purpose of the TTG-DGP Screen test is to screen for celiac disease by detecting circulating antibodies to tissue transglutaminase and deamidated gliadin peptides. It aids clinicians in identifying individuals who require further evaluation for celiac disease, especially those presenting with typical or atypical symptoms or with a high risk due to family history or associated autoimmune conditions.

Test Code
3699
ICD Code
K90.0
Price
₹2,223
Sample Type
Serum
Result Time
Reports are typically available the same day if the sample reaches the lab by 9 am. Otherwise, reports are delivered within 24 hours.
Fasting Required
No
Method
Enzyme Immunoassay (EIA), ELISA
Step 1

Sample Collection

No special preparation is required. However, the patient should be on a gluten-containing diet (at least 2 slices of wheat bread per day or equivalent) for 4-6 weeks before the test to avoid false-negative results. If gluten has already been removed from the diet, a gluten challenge may be considered under medical supervision.

Method: Blood draw

Step 2

Laboratory Analysis

A blood sample is drawn from a vein in the arm by trained phlebotomist. The procedure takes about 5 minutes.

Step 3

Report Delivery

No specific post-collection precautions. Patients can resume normal activities immediately.

Timeline: Reports are typically available the same day if the sample reaches the lab by 9 am. Otherwise, reports are delivered within 24 hours.

Patient Instructions

1
Before the Test:No special preparation is required. Maintain a gluten-containing diet for 4-6 weeks before blood collection. Avoid starting a gluten-free diet prior to testing unless advised by a physician.
2
During the Test:A blood sample is taken from a vein in the arm. Minimal discomfort may be felt at the needle insertion site.
3
After the Test:There is no downtime after the test. You can continue your daily activities. A bandage may be placed on the puncture site for a few hours.

About This Test

Who Should Get This Test

The purpose of the TTG-DGP Screen test is to screen for celiac disease by detecting circulating antibodies to tissue transglutaminase and deamidated gliadin peptides. It aids clinicians in identifying individuals who require further evaluation for celiac disease, especially those presenting with typical or atypical symptoms or with a high risk due to family history or associated autoimmune conditions.

How to Prepare

  • Confirm patient identity before collection.
  • Collect 2 mL of venous blood into an SST (serum separator tube).
  • Allow the sample to clot for 30 minutes at room temperature.
  • Label the tube with patient name, date, and time of collection.
  • Transport the sample to the laboratory within 8 hours at room temperature; if delayed, refrigerate at 2-8°C.

Doctor's Notes

Reviewed by — MBBS, MD (Pathology) · Reg. No. 21521

"For accurate celiac disease screening, TTG-DGP simultaneous detection is recommended, especially in patients with IgA deficiency. A gastroenterologist should interpret the results in the context of clinical findings and may advise an endoscopic biopsy for confirmation before lifelong gluten exclusion."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeSerum
Sample Volume2 mL (1 mL min.)
ContainerSST (Serum Separator Tube)
Collection MethodBlood draw

Sample Stability

Room temperature: 8 hours
Refrigerator (2-8°C): 48 hours
Frozen (-20°C): 4 weeks
Sample Rejection Criteria:
  • Hemolyzed, lipemic, or icteric samples
  • Improperly labeled or unlabeled samples
  • Samples received after the stability period
  • Samples from patients who have been on a gluten-free diet for more than 2 weeks (unless medically indicated)

Understanding Your Results

The TTG-DGP Screen test results are interpreted semiquantitatively. Positive results indicate possible celiac disease, while negative results suggest lower likelihood.
📊

Any positive tTG IgA, tTG IgG, DGP IgA, or DGP IgG

Suggests celiac disease. Further evaluation with upper gastrointestinal endoscopy and duodenal biopsy is recommended to confirm the diagnosis.

📊

All parameters negative (below cutoff)

Celiac disease is unlikely. However, if clinical suspicion remains high, consider HLA-DQ2/DQ8 genotyping or repeat testing after ensuring a gluten-containing diet.

📊

IgA-based tests negative and DGP IgG positive (or vice versa)

This pattern may be seen in selective IgA deficiency. DGP IgG and tTG IgG provide support for celiac disease in such patients.

⚠️ When to Consult a Doctor:

Consult a gastroenterologist if you have persistent diarrhea, chronic abdominal pain, bloating, unexplained iron deficiency anemia, or a family history of celiac disease. Also, if your TTG-DGP Screen test is positive, prompt medical evaluation is essential.

Limitations

  • ⚠A negative result does not entirely exclude celiac disease, especially in patients on gluten-free diet.
  • ⚠Positive results require confirmatory endoscopic biopsy before diagnosing celiac disease.
  • ⚠This test is not suitable for monitoring response to gluten-free diet.
  • ⚠Reference ranges may vary by laboratory; results should be interpreted by a qualified clinician.

Risks & Considerations

  • ●Minor bruising at the venipuncture site
  • ●Dizziness or lightheadedness during or after blood draw
  • ●Rare risk of infection or excessive bleeding

Interfering Factors

  • ●IgA deficiency can cause false-negative results for IgA-based antibody assays.
  • ●Immunosuppressive medications (e.g., corticosteroids, azathioprine) may reduce antibody levels.
  • ●Patients already on a strict gluten-free diet for several weeks may have low or undetectable antibodies.
  • ●Young children (<2 years) may have lower antibody levels, especially anti-tTG.

Compare With Similar Tests

TestTissue Transglutaminase TTG-DGP Screen Test
ComparisonTissue Transglutaminase TTG-DGP Screen Test

Frequently Asked Questions

What is the TTG-DGP Screen Test?
The TTG-DGP Screen Test is a blood test that simultaneously detects IgA and IgG antibodies to tissue transglutaminase (tTG) and deamidated gliadin peptides (DGP). It is used to screen for celiac disease.
Is fasting required for this test?
No, fasting is not required. You can eat and drink normally unless advised otherwise by your doctor.
What is the cost of the TTG-DGP Screen Test at DNA Labs India?
The test costs INR 2223. This includes home sample collection and same-day report delivery in most major Indian cities.
How accurate is the TTG-DGP Screen test for celiac disease?
The test has high sensitivity and specificity, particularly when both IgA and IgG antibodies are measured. However, an intestinal biopsy remains the gold standard for confirming the diagnosis.
Can I undergo this test while on a gluten-free diet?
It is not recommended. Gluten must be present in your diet for at least 4-6 weeks before testing to avoid false-negative results. If you are already gluten-free, consult your doctor about a gluten challenge.
What does a positive TTG-DGP result mean?
A positive result indicates the presence of celiac-associated antibodies. This suggests celiac disease, but you will likely need an endoscopic biopsy to confirm the diagnosis before starting a gluten-free diet.
Is the test useful in patients with IgA deficiency?
Yes. Because both IgA and IgG antibodies are measured, the test can accurately detect celiac disease even in people with selective IgA deficiency, who may have false-negative results on IgA-only tests.
What is the difference between tTG and DGP antibodies?
tTG antibodies target tissue transglutaminase enzyme, while DGP antibodies target deamidated gliadin peptides. DGP antibodies may appear earlier in children, and tTG antibodies are highly specific for celiac disease.
How quickly will I get my report?
If your blood sample reaches the laboratory by 9 am, the report will be delivered the same day. Otherwise, it will be provided within 24 hours.
Are there any risks associated with the test?
The test involves a routine blood draw, so risks are minimal. You may experience minor bruising or discomfort at the needle site, which resolves quickly.
Which other tests are recommended if my TTG-DGP result is positive?
If positive, your doctor may recommend an upper GI endoscopy with duodenal biopsy to confirm celiac disease. Genetic testing (HLA DQ2/DQ8) may also be helpful in uncertain cases.
Does the price include home sample collection?
Yes, DNA Labs India provides free home sample collection for online bookings. The special discounted price of INR 2223 includes this service.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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