ZBTB16 Gene Leukemia: Understanding the Acute Promyelocytic Type with PL2F/RARA

Leukemia, a cancer of blood-forming tissues, is a prevalent disease that affects millions of people worldwide. One of its types is acute promyelocytic leukemia (APL), which is characterized by abnormal proliferation of immature white blood cells called promyelocytes. APL is linked to a genetic mutation in the ZBTB16 gene, which leads to the formation of a fusion protein PL2F/RARA. This abnormal protein interferes with the normal functioning of blood cells, leading to the development of leukemia.

Symptoms of APL

APL shares many symptoms with other types of leukemia, such as fatigue, fever, and weakness. However, it has some specific symptoms that can help in its diagnosis. These include:

• Bleeding gums or nose
• Difficulty breathing
• Easy bruising or bleeding
• Frequent infections
• Joint pain
• Pale skin
• Petechiae (tiny red spots on the skin)
• Sudden weight loss
• Sweating at night

Diagnosis of APL

Diagnosis of APL involves a series of tests that help in determining the type and severity of leukemia. These tests include:

• Physical examination and medical history
• Blood tests to check for abnormal white blood cells and clotting factors
• Bone marrow biopsy to collect and examine bone marrow cells
• Imaging tests such as X-rays, CT scans, and MRI to detect any abnormalities in the body

NGS Genetic Test for APL

Next-generation sequencing (NGS) is a powerful tool that can help in identifying genetic mutations associated with APL. This test involves analyzing DNA samples collected from blood or bone marrow to detect any abnormalities in the ZBTB16 gene. NGS can accurately identify the fusion protein PL2F/RARA, which is critical for the diagnosis and treatment of APL.

Cost of NGS Genetic Test for APL

The cost of NGS Genetic Test for APL in India ranges from INR 20,000 to INR 30,000, depending on the laboratory and the location. However, the cost may vary based on the additional tests required for the diagnosis and treatment of APL.

Conclusion

APL is a severe form of leukemia that requires accurate diagnosis and prompt treatment. Understanding the symptoms and genetic mutations associated with APL can help in its early detection and treatment. NGS Genetic Test is a reliable and accurate tool that can help in identifying the ZBTB16 gene mutation and PL2F/RARA fusion protein, which are critical for the diagnosis and treatment of APL. If you experience any symptoms of APL, it is essential to consult a healthcare professional for timely diagnosis and treatment.

For more information and to schedule an NGS Genetic Test for APL, contact DNA Labs India today!

Before getting tested ask for Raw Data, FASTQ, and VCF files along with clinical test report from DNA Testing Lab. DNA Labs India is the Only lab that is transparent and will share Raw Data, FASTQ, and VCF files along with the conclusive clinical report for ZBTB16 Gene Leukemia, acute promyelocytic, PL2F/RARA type NGS Genetic Test

 Note: We offer free home sample collection for online bookings for ZBTB16 Gene Leukemia, acute promyelocytic, PL2F/RARA type NGS Genetic Test and the test costs a special discounted price of 20000 INR across India. The cities where this service is available include Mumbai, Delhi, Bangalore, Hyderabad, Ahmedabad, Chennai, Kolkata, Surat, Pune, Jaipur, Lucknow, Kanpur, Nagpur, Indore, Thane, Bhopal, Visakhapatnam, Pimpri-Chinchwad, Patna, Vadodara, Ghaziabad, Ludhiana, Agra, Nashik, Faridabad, Meerut, Rajkot, Kalyan-Dombivali, Vasai-Virar, Varanasi, Srinagar, Aurangabad, Dhanbad, Amritsar, Navi Mumbai, Prayagraj, Howrah, Ranchi, Jabalpur, Gwalior, Coimbatore, Vijayawada, Jodhpur, Madurai, Raipur, Kota, Guwahati, Chandigarh, Thiruvananthapuram, Solapur, Hubballi-Dharwad, Tiruchirappalli, Tiruppur, Moradabad, Mysore, Bareily, Gurgaon, Aligarh, Jalandhar, Bhubaneswar, Salem, Mira-Bhayandar, Warangal , Guntur , Bhiwandi, Saharanpur, Gorakhpur, Bikaner, Amravati, Noida, Jamshedpur, Bhilai, Cuttack, Firozabad, Kochi, Nellore , Bhavnagar, Dehradun, Durgapur, Asansol, Rourkela, Nanded, Kolhapur, Ajmer, Akola, Gulbarga, Jamnagar, Ujjain, Loni, Siliguri, Jhansi, Ulhasnagar, Jammu, Sangli-Miraj & Kupwad, Mangalore, Erode10, Belgaum, Ambattur, Tirunelveli, Malegaon, Gaya, Jalgaon, Udaipur, Maheshtala, Davanagere, Kozhikode, Kurnool, Rajpur Sonarpur, Rajahmundry , Bokaro, South Dumdum, Bellary, Patiala, Gopalpur, Agartala, Bhagalpur, Muzaffarnagar, Bhatpara, Panihati, Latur, Dhule, Tirupati , Rohtak, Korba, Bhilwara, Berhampur, Muzaffarpur, Ahmednagar, Mathura, Kollam, Avadi, Kadapa, Kamarhati, Sambalpur, Bilaspur, Shahjahanpur, Satara, Bijapur, Rampur, Shivamogga, Chandrapur, Junagadh, Thrissur, Alwar, Bardhaman, Kulti, Kakinada, Nizamabad, Parbhani, Tumkur, Khammam, Ozhukarai, Bihar Sharif, Panipat, Darbhanga, Bally, Aizawl, Dewas, Ichalkaranji, Karnal, Bathinda, Jalna, Eluru, Kirari Suleman Nagar, Barasat, Purnia, Satna, Mau, Sonipat, Farrukhabad, Sagar, Rourkela, Durg, Imphal, Ratlam, Hapur, Arrah, Karimnagar, Anantapur, Etawah, Ambernath, North Dumdum, Bharatpur, Begusarai, New Delhi, Gandhidham, Baranagar, Tiruvottiyur, Puducherry, Sikar, Thoothukudi, Rewa, Mirzapur, Raichur, Pali, Ramagundam , Haridwar, Vijayanagaram, Katihar, Nagarcoil, Sri Ganganagar, Karawal Nagar, Mango, Thanjavur, Bulandshahr, Uluberia, Murwara, Sambhal, Singrauli, Nadiad, Secunderabad, Naihati, Yamunanagar, Bidhan Nagar, Pallavaram, Bidar, Munger, Panchkula, Burhanpur, Raurkela Industrial Township, Kharagpur, Dindigul, Gandhinagar, Hospet, Nangloi Jat, Malda, Ongole, Deoghar, Chapra, Haldia, Khandwa, Nandyal, Chittoor , Morena, Amroha, Anand, Bhind, Bhalswa Jahangir Pur, Madhyamgram, Bhiwani, Navi Mumbai Panvel Raigad, Baharampur, Ambala, Morvi, Fatehpur, Rae Bareli, Khora, Bhusawal, Orai, Bahraich, Vellore, Mahesana, Sambalpur, Raiganj, Sirsa, Danapur, Serampore, Sultan Pur Majra, Guna, Jaunpur, Panvel, Shivpuri, Surendranagar Dudhrej, Unnao, Hugli and Chinsurah, Alappuzha, Kottayam, Machilipatnam, Shimla, Adoni, Tenali, Proddatur, Saharsa, Hindupur, Sasaram, Hajipur, Bhimavaram, Dehri, Madanapalle, Siwan, Bettiah, Guntakal, Srikakulam, Motihari, Dharmavaram, Gudivada, Narasaraopet, Bagaha, Miryalaguda, Tadipatri, Kishanganj, Karaikudi, Suryapet, Jamalpur, Kavali, Tadepalligudem, Amaravati, Buxar, Jehanabad, Aurangabad.