DNAAF3 Gene and Primary Ciliary Dyskinesia Type 2: Symptoms, Diagnosis, and NGS Genetic Test Cost
Primary Ciliary Dyskinesia (PCD) is a rare genetic disorder that affects the respiratory tract, causing chronic respiratory infections, sinusitis, and bronchiectasis. The DNAAF3 gene is one of the genes that have been identified as being involved in PCD. In this blog post, we will discuss the symptoms and diagnosis of PCD type 2, the role of the DNAAF3 gene in PCD, and the cost of NGS Genetic Testing for this disorder.
Symptoms of PCD Type 2
PCD type 2 is a subtype of PCD that is caused by mutations in the DNAAF3 gene. The symptoms of PCD type 2 are similar to those of other subtypes of PCD and include:
- Chronic cough
- Chronic respiratory infections
- Sinusitis
- Ear infections
- Shortness of breath
- Nasal congestion
- Fatigue
- Pneumonia
- Wheezing
- Difficulty breathing
These symptoms can vary in severity and may worsen over time.
Diagnosis of PCD Type 2
Diagnosis of PCD type 2 can be challenging, as the symptoms are similar to those of other respiratory conditions. A diagnosis of PCD type 2 is typically made based on a combination of clinical symptoms, imaging studies, and genetic testing.
Imaging studies, such as a high-resolution computed tomography (HRCT) scan, can reveal characteristic abnormalities in the respiratory tract that are indicative of PCD. Genetic testing can also be used to confirm a diagnosis of PCD type 2 by identifying mutations in the DNAAF3 gene.
The Role of the DNAAF3 Gene in PCD
The DNAAF3 gene provides instructions for making a protein called axonemal dynein assembly factor 3, which is essential for the proper functioning of cilia. Cilia are hair-like structures that line the respiratory tract and are responsible for clearing mucus and debris from the lungs.
Mutations in the DNAAF3 gene can disrupt the function of cilia, leading to impaired clearance of mucus and debris from the respiratory tract. This can result in chronic respiratory infections, sinusitis, and bronchiectasis, which are characteristic of PCD.
NGS Genetic Test Cost for PCD Type 2
Next-generation sequencing (NGS) Genetic Testing can be used to identify mutations in the DNAAF3 gene and confirm a diagnosis of PCD type 2. The cost of NGS Genetic Testing for PCD type 2 in India is approximately INR 20,000.
NGS Genetic Testing is a highly sensitive and specific diagnostic tool that can provide a definitive diagnosis of PCD type 2. It can also be used to identify carriers of PCD type 2 mutations, which can be helpful for family planning and genetic counseling.
Conclusion
PCD type 2 is a rare genetic disorder that is caused by mutations in the DNAAF3 gene. The symptoms of PCD type 2 are similar to those of other subtypes of PCD and can be challenging to diagnose. NGS Genetic Testing can be used to confirm a diagnosis of PCD type 2 and is a valuable diagnostic tool for this disorder. The cost of NGS Genetic Testing for PCD type 2 in India is approximately INR 20,000.
| Test Name | DNAAF3 Gene Primary ciliary dyskinesia type 2 NGS Genetic Test |
|---|---|
| Sample type | Blood or Extracted DNA or One drop Blood on FTA Card |
| Test type | ENT Doctor |
| Pre-test Information | Clinical History of Patient who is going for SLC52A3 Gene Brown-Vialetto-Van Laere syndrome 1 NGS Genetic Test. A Genetic Counselling session to draw a pedigree chart of family members affected with SLC52A3 Gene Brown-Vialetto-Van Laere syndrome 1 NGS Genetic Test gene SLC52A19 |
| Disease | Ear Nose Throat Disorders |
| Method | NGS Technology |
| Purpose | NULL |
| Preparation | Ambient Room Temperature |
| Fasting | Clinical History of Patient who is going for SLC52A3 Gene Brown-Vialetto-Van Laere syndrome 1 NGS Genetic Test. A Genetic Counselling session to draw a pedigree chart of family members affected with SLC52A3 Gene Brown-Vialetto-Van Laere syndrome 1 NGS Genetic Test gene SLC52A19 |
| Get Reports | 3 to 4 Weeks |
| Test Price | INR ₹ 20000 |
Note: We offer free home sample collection for online bookings for DNAAF3 Gene Primary ciliary dyskinesia type 2 NGS Genetic Test and the test costs a special discounted price of 20000 INR across India. The cities where this service is available include Mumbai, Delhi, Bangalore, Hyderabad, Ahmedabad, Chennai, Kolkata, Surat, Pune, Jaipur, Lucknow, Kanpur, Nagpur, Indore, Thane, Bhopal, Visakhapatnam, Pimpri-Chinchwad, Patna, Vadodara, Ghaziabad, Ludhiana, Agra, Nashik, Faridabad, Meerut, Rajkot, Kalyan-Dombivali, Vasai-Virar, Varanasi, Srinagar, Aurangabad, Dhanbad, Amritsar, Navi Mumbai, Prayagraj, Howrah, Ranchi, Jabalpur, Gwalior, Coimbatore, Vijayawada, Jodhpur, Madurai, Raipur, Kota, Guwahati, Chandigarh, Thiruvananthapuram, Solapur, Hubballi-Dharwad, Tiruchirappalli, Tiruppur, Moradabad, Mysore, Bareily, Gurgaon, Aligarh, Jalandhar, Bhubaneswar, Salem, Mira-Bhayandar, Warangal , Guntur , Bhiwandi, Saharanpur, Gorakhpur, Bikaner, Amravati, Noida, Jamshedpur, Bhilai, Cuttack, Firozabad, Kochi, Nellore , Bhavnagar, Dehradun, Durgapur, Asansol, Rourkela, Nanded, Kolhapur, Ajmer, Akola, Gulbarga, Jamnagar, Ujjain, Loni, Siliguri, Jhansi, Ulhasnagar, Jammu, Sangli-Miraj & Kupwad, Mangalore, Erode10, Belgaum, Ambattur, Tirunelveli, Malegaon, Gaya, Jalgaon, Udaipur, Maheshtala, Davanagere, Kozhikode, Kurnool, Rajpur Sonarpur, Rajahmundry , Bokaro, South Dumdum, Bellary, Patiala, Gopalpur, Agartala, Bhagalpur, Muzaffarnagar, Bhatpara, Panihati, Latur, Dhule, Tirupati , Rohtak, Korba, Bhilwara, Berhampur, Muzaffarpur, Ahmednagar, Mathura, Kollam, Avadi, Kadapa, Kamarhati, Sambalpur, Bilaspur, Shahjahanpur, Satara, Bijapur, Rampur, Shivamogga, Chandrapur, Junagadh, Thrissur, Alwar, Bardhaman, Kulti, Kakinada, Nizamabad, Parbhani, Tumkur, Khammam, Ozhukarai, Bihar Sharif, Panipat, Darbhanga, Bally, Aizawl, Dewas, Ichalkaranji, Karnal, Bathinda, Jalna, Eluru, Kirari Suleman Nagar, Barasat, Purnia, Satna, Mau, Sonipat, Farrukhabad, Sagar, Rourkela, Durg, Imphal, Ratlam, Hapur, Arrah, Karimnagar, Anantapur, Etawah, Ambernath, North Dumdum, Bharatpur, Begusarai, New Delhi, Gandhidham, Baranagar, Tiruvottiyur, Puducherry, Sikar, Thoothukudi, Rewa, Mirzapur, Raichur, Pali, Ramagundam , Haridwar, Vijayanagaram, Katihar, Nagarcoil, Sri Ganganagar, Karawal Nagar, Mango, Thanjavur, Bulandshahr, Uluberia, Murwara, Sambhal, Singrauli, Nadiad, Secunderabad, Naihati, Yamunanagar, Bidhan Nagar, Pallavaram, Bidar, Munger, Panchkula, Burhanpur, Raurkela Industrial Township, Kharagpur, Dindigul, Gandhinagar, Hospet, Nangloi Jat, Malda, Ongole, Deoghar, Chapra, Haldia, Khandwa, Nandyal, Chittoor , Morena, Amroha, Anand, Bhind, Bhalswa Jahangir Pur, Madhyamgram, Bhiwani, Navi Mumbai Panvel Raigad, Baharampur, Ambala, Morvi, Fatehpur, Rae Bareli, Khora, Bhusawal, Orai, Bahraich, Vellore, Mahesana, Sambalpur, Raiganj, Sirsa, Danapur, Serampore, Sultan Pur Majra, Guna, Jaunpur, Panvel, Shivpuri, Surendranagar Dudhrej, Unnao, Hugli and Chinsurah, Alappuzha, Kottayam, Machilipatnam, Shimla, Adoni, Tenali, Proddatur, Saharsa, Hindupur, Sasaram, Hajipur, Bhimavaram, Dehri, Madanapalle, Siwan, Bettiah, Guntakal, Srikakulam, Motihari, Dharmavaram, Gudivada, Narasaraopet, Bagaha, Miryalaguda, Tadipatri, Kishanganj, Karaikudi, Suryapet, Jamalpur, Kavali, Tadepalligudem, Amaravati, Buxar, Jehanabad, Aurangabad.
