GDNF Gene Hirschsprung Disease: Symptoms, Diagnosis, and NGS Genetic Test Cost
Hirschsprung disease, also known as congenital megacolon, is a rare condition that affects the large intestine or colon. This disease occurs when the nerve cells that control the muscles in the colon do not develop properly. As a result, the muscles in the colon cannot relax and move stool through the intestine, leading to constipation, abdominal swelling, and other symptoms.
There are several genes that have been associated with Hirschsprung disease, and one of them is the GDNF gene. This gene provides instructions for making a protein called glial cell line-derived neurotrophic factor, which is essential for the development and survival of nerve cells in the colon.
Symptoms of GDNF Gene Hirschsprung Disease
The symptoms of Hirschsprung disease can vary depending on the severity of the condition. In GDNF gene Hirschsprung disease, the symptoms may be more severe than in other types of the disease. Some of the common symptoms of GDNF gene Hirschsprung disease include:
- Constipation that starts from birth or shortly after
- Abdominal swelling or distension
- Lack of bowel movements in infants
- Difficulty passing stools
- Diarrhea
- Malnutrition
- Vomiting
Diagnosis of GDNF Gene Hirschsprung Disease
Diagnosis of GDNF gene Hirschsprung disease requires a thorough medical history and physical examination. Doctors may also recommend several tests to confirm the diagnosis. Some of the common tests for diagnosing Hirschsprung disease include:
- Anorectal manometry
- Barium enema
- Rectal biopsy
- Colonoscopy
If the diagnosis is confirmed, genetic testing may be recommended to identify the specific gene mutation that causes Hirschsprung disease. This can help in determining the best treatment options and prognosis for the patient.
NGS Genetic Test Cost for GDNF Gene Hirschsprung Disease
Next-generation sequencing (NGS) is a type of genetic test that can be used to detect mutations in the GDNF gene associated with Hirschsprung disease. This test is highly accurate and can identify the specific genetic mutation causing the disease.
The cost of NGS Genetic Testing for GDNF gene Hirschsprung disease in India is approximately INR 20,000. This cost may vary depending on the laboratory and location of the test.
Conclusion
GDNF gene Hirschsprung disease is a rare genetic condition that can cause severe symptoms in affected individuals. If you or your child is experiencing symptoms of Hirschsprung disease, it is important to seek medical attention and get an accurate diagnosis. Genetic testing, such as NGS DNA testing, can help in identifying the specific gene mutation causing the disease and determining the best treatment options. At DNA Labs India, we offer highly accurate and affordable genetic testing services to help individuals and families get the answers they need.
Before getting tested ask for Raw Data, FASTQ, and VCF files along with clinical test report from DNA Testing Lab. DNA Labs India is the Only lab that is transparent and will share Raw Data, FASTQ, and VCF files along with the conclusive clinical report for GDNF Gene Hirschsprung disease, type 3, susceptibility to NGS Genetic Test
| Test Name | GDNF Gene Hirschsprung disease, type 3, susceptibility to NGS Genetic Test |
|---|---|
| Sample type | Blood or Extracted DNA or One drop Blood on FTA Card |
| Test type | Pediatrics |
| Pre-test Information | Clinical History of Patient who is going for GDNF Gene Hirschsprung disease, type 3, susceptibility to NGS Genetic Test. A Genetic Counselling session to draw a pedigree chart of family members affected with GDNF Gene Hirschsprung disease, type 3, susceptibility to NGS Genetic Test gene GDNF |
| Disease | Dysmorphology |
| Method | NGS Technology |
| Purpose | NULL |
| Preparation | Ambient Room Temperature |
| Fasting | Clinical History of Patient who is going for GDNF Gene Hirschsprung disease, type 3, susceptibility to NGS Genetic Test. A Genetic Counselling session to draw a pedigree chart of family members affected with GDNF Gene Hirschsprung disease, type 3, susceptibility to NGS Genetic Test gene GDNF |
| Get Reports | 3 to 4 Weeks |
| Test Price | INR ₹ 20000 |
Note: We offer free home sample collection for online bookings for GDNF Gene Hirschsprung disease, type 3, susceptibility to NGS Genetic Test and the test costs a special discounted price of 20000 INR across India. The cities where this service is available include Mumbai, Delhi, Bangalore, Hyderabad, Ahmedabad, Chennai, Kolkata, Surat, Pune, Jaipur, Lucknow, Kanpur, Nagpur, Indore, Thane, Bhopal, Visakhapatnam, Pimpri-Chinchwad, Patna, Vadodara, Ghaziabad, Ludhiana, Agra, Nashik, Faridabad, Meerut, Rajkot, Kalyan-Dombivali, Vasai-Virar, Varanasi, Srinagar, Aurangabad, Dhanbad, Amritsar, Navi Mumbai, Prayagraj, Howrah, Ranchi, Jabalpur, Gwalior, Coimbatore, Vijayawada, Jodhpur, Madurai, Raipur, Kota, Guwahati, Chandigarh, Thiruvananthapuram, Solapur, Hubballi-Dharwad, Tiruchirappalli, Tiruppur, Moradabad, Mysore, Bareily, Gurgaon, Aligarh, Jalandhar, Bhubaneswar, Salem, Mira-Bhayandar, Warangal , Guntur , Bhiwandi, Saharanpur, Gorakhpur, Bikaner, Amravati, Noida, Jamshedpur, Bhilai, Cuttack, Firozabad, Kochi, Nellore , Bhavnagar, Dehradun, Durgapur, Asansol, Rourkela, Nanded, Kolhapur, Ajmer, Akola, Gulbarga, Jamnagar, Ujjain, Loni, Siliguri, Jhansi, Ulhasnagar, Jammu, Sangli-Miraj & Kupwad, Mangalore, Erode10, Belgaum, Ambattur, Tirunelveli, Malegaon, Gaya, Jalgaon, Udaipur, Maheshtala, Davanagere, Kozhikode, Kurnool, Rajpur Sonarpur, Rajahmundry , Bokaro, South Dumdum, Bellary, Patiala, Gopalpur, Agartala, Bhagalpur, Muzaffarnagar, Bhatpara, Panihati, Latur, Dhule, Tirupati , Rohtak, Korba, Bhilwara, Berhampur, Muzaffarpur, Ahmednagar, Mathura, Kollam, Avadi, Kadapa, Kamarhati, Sambalpur, Bilaspur, Shahjahanpur, Satara, Bijapur, Rampur, Shivamogga, Chandrapur, Junagadh, Thrissur, Alwar, Bardhaman, Kulti, Kakinada, Nizamabad, Parbhani, Tumkur, Khammam, Ozhukarai, Bihar Sharif, Panipat, Darbhanga, Bally, Aizawl, Dewas, Ichalkaranji, Karnal, Bathinda, Jalna, Eluru, Kirari Suleman Nagar, Barasat, Purnia, Satna, Mau, Sonipat, Farrukhabad, Sagar, Rourkela, Durg, Imphal, Ratlam, Hapur, Arrah, Karimnagar, Anantapur, Etawah, Ambernath, North Dumdum, Bharatpur, Begusarai, New Delhi, Gandhidham, Baranagar, Tiruvottiyur, Puducherry, Sikar, Thoothukudi, Rewa, Mirzapur, Raichur, Pali, Ramagundam , Haridwar, Vijayanagaram, Katihar, Nagarcoil, Sri Ganganagar, Karawal Nagar, Mango, Thanjavur, Bulandshahr, Uluberia, Murwara, Sambhal, Singrauli, Nadiad, Secunderabad, Naihati, Yamunanagar, Bidhan Nagar, Pallavaram, Bidar, Munger, Panchkula, Burhanpur, Raurkela Industrial Township, Kharagpur, Dindigul, Gandhinagar, Hospet, Nangloi Jat, Malda, Ongole, Deoghar, Chapra, Haldia, Khandwa, Nandyal, Chittoor , Morena, Amroha, Anand, Bhind, Bhalswa Jahangir Pur, Madhyamgram, Bhiwani, Navi Mumbai Panvel Raigad, Baharampur, Ambala, Morvi, Fatehpur, Rae Bareli, Khora, Bhusawal, Orai, Bahraich, Vellore, Mahesana, Sambalpur, Raiganj, Sirsa, Danapur, Serampore, Sultan Pur Majra, Guna, Jaunpur, Panvel, Shivpuri, Surendranagar Dudhrej, Unnao, Hugli and Chinsurah, Alappuzha, Kottayam, Machilipatnam, Shimla, Adoni, Tenali, Proddatur, Saharsa, Hindupur, Sasaram, Hajipur, Bhimavaram, Dehri, Madanapalle, Siwan, Bettiah, Guntakal, Srikakulam, Motihari, Dharmavaram, Gudivada, Narasaraopet, Bagaha, Miryalaguda, Tadipatri, Kishanganj, Karaikudi, Suryapet, Jamalpur, Kavali, Tadepalligudem, Amaravati, Buxar, Jehanabad, Aurangabad.
