Hereditary Spastic Paraplegia Gene Panel Test
Short Name: HSP Gene Panel
Also known as: HSP Gene Panel, Spastic Paraplegia Genetic Test, HSP NGS Panel
Hereditary Spastic Paraplegia Gene Panel Test test available at DNA Labs India for ₹36,000. Uses Next-Generation Sequencing (NGS) on Peripheral Blood samples. Results in Reports are typically available within 4-6 weeks after the sample reaches the laboratory.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
The primary purpose of the HSP gene panel is to detect pathogenic variants in genes known to cause hereditary spastic paraplegia. This test aids in: confirming a clinical diagnosis, differentiating HSP from other neurological conditions with similar symptoms, identifying the specific genetic subtype which can inform prognosis and management, and enabling genetic counseling for affected individuals and their families. It is also useful for presymptomatic testing in at-risk family members when a pathogenic variant has been identified in the family.
- Test Code
- 6110
- CPT Code
- 81408
- ICD Code
- G11.4
- Price
- ₹36,000
- Sample Type
- Peripheral Blood
- Result Time
- Reports are typically available within 4-6 weeks after the sample reaches the laboratory.
- Fasting Required
- No
- Method
- Next-Generation Sequencing (NGS)
Sample Collection
No special preparation is required. However, a doctor's prescription is recommended. Inform your doctor about any medications you are taking.
Method: Venipuncture
Laboratory Analysis
A blood sample will be drawn from a vein in your arm. The procedure is quick and minimally invasive.
Report Delivery
You may resume normal activities immediately. There are no restrictions after blood collection.
Timeline: Reports are typically available within 4-6 weeks after the sample reaches the laboratory.
Patient Instructions
About This Test
Who Should Get This Test
The primary purpose of the HSP gene panel is to detect pathogenic variants in genes known to cause hereditary spastic paraplegia. This test aids in: confirming a clinical diagnosis, differentiating HSP from other neurological conditions with similar symptoms, identifying the specific genetic subtype which can inform prognosis and management, and enabling genetic counseling for affected individuals and their families. It is also useful for presymptomatic testing in at-risk family members when a pathogenic variant has been identified in the family.
How to Prepare
- Ensure the sample is collected in an EDTA vacutainer.
- For prenatal samples (amniotic fluid/chorionic villi), use sterile container.
- Transport samples at room temperature or as instructed.
- Avoid hemolysis of blood sample.
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"HSP is a clinically and genetically heterogeneous disorder. Genetic testing is essential for confirming diagnosis, guiding prognosis, and enabling family counseling."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed blood sample
- Clotted blood sample
- Incorrect container
- Sample not labeled properly
- Sample received after prolonged delay
Understanding Your Results
Positive
A pathogenic or likely pathogenic variant was detected in a gene associated with HSP. This confirms the genetic diagnosis and can guide management and family counseling.
Negative
No pathogenic variants were detected in the analyzed genes. This does not rule out HSP, as other genetic or non-genetic causes may be present.
Variant of Uncertain Significance (VUS)
A genetic variant was found, but its clinical significance is unknown. Further testing or family studies may be needed to clarify.
Consult a doctor if you or a family member experience progressive leg stiffness, weakness, or difficulty walking. Early evaluation and genetic testing can help in diagnosis and management.
Limitations
- ⚠This panel does not detect all possible genetic causes of HSP; some rare genes may not be included.
- ⚠Variants of uncertain significance may be reported; further testing may be required.
- ⚠Negative result does not exclude HSP if clinical suspicion is high.
- ⚠Not recommended for asymptomatic individuals without family history.
Risks & Considerations
- ●Minimal risk of bruising or bleeding at the puncture site
- ●Rare risk of infection
- ●Psychological impact of genetic results
Interfering Factors
- ●Contamination of blood sample
- ●Insufficient DNA quantity
- ●Presence of maternal cell contamination in prenatal samples
- ●Genetic variants of uncertain significance
- ●Large deletions/duplications not detected by NGS
Compare With Similar Tests
| Test | Hereditary Spastic Paraplegia Gene Panel | Single Gene Testing | Whole Exome Sequencing | Chromosomal Microarray |
|---|---|---|---|---|
| Comparison | Hereditary Spastic Paraplegia Gene Panel | Targets one specific gene, less comprehensive, may miss other causes. | Analyzes all coding regions, more comprehensive but higher cost and longer turnaround. | Detects large deletions/duplications, but not point mutations. |
Frequently Asked Questions
What is the cost of the Hereditary Spastic Paraplegia Gene Panel?
What sample is required for the HSP gene panel?
Is fasting required before the test?
How long does it take to get results?
Is home sample collection available?
What genes are included in the panel?
Can this test be done during pregnancy?
Is a doctor's prescription necessary?
What does a positive result mean?
What if the result is negative?
Are there any risks associated with the test?
Is the test covered by insurance?
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