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Interleukin 28B rs12979860 & rs 8099917 Genotyping Qualitative PCR Test

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Interleukin 28B rs12979860 & rs 8099917 Genotyping Qualitative PCR Test

Short Name: IL28B Genotyping Test

Also known as: IL28B rs12979860 rs8099917 PCR Test, Interleukin 28B Genotyping, IL28B SNP Genotyping Test

Interleukin 28B rs12979860 & rs 8099917 Genotyping Qualitative PCR Test test available at DNA Labs India for ₹7,500. Uses Qualitative PCR on Whole blood samples. Results in Reports are typically available within 2-3 business days after sample receipt at the laboratory. Delays may occur due to holidays or sample quality issues.. Free home collection in 300+ cities across India.

Qualitative PCR🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr Pasupathy Arumugam

Dr Pasupathy Arumugam

Consultant Pathologist · Reg: 21521

Last reviewed: September 7, 2026

Overview

The purpose of the IL28B Genotyping Test is to determine the genetic variants at rs12979860 and rs8099917 positions, which are biomarkers for predicting treatment response in hepatitis C patients. This information aids healthcare providers in selecting the most effective therapy, improving treatment outcomes, and assessing the risk of disease progression.

Test Code
1117
Price
₹7,500
Sample Type
Whole blood
Result Time
Reports are typically available within 2-3 business days after sample receipt at the laboratory. Delays may occur due to holidays or sample quality issues.
Fasting Required
No
Method
Qualitative PCR
Step 1

Sample Collection

No special preparation such as fasting is required. Inform your doctor about any medications, especially anticoagulants, before sample collection.

Method: Venipuncture

Step 2

Laboratory Analysis

A healthcare professional will draw approximately 3 mL of blood from a vein in your arm using a sterile needle and lavender-top EDTA tube. The process takes only a few minutes.

Step 3

Report Delivery

Apply gentle pressure to the puncture site with a cotton ball to stop bleeding. You may resume normal activities immediately. Avoid strenuous arm activity for a few hours.

Timeline: Reports are typically available within 2-3 business days after sample receipt at the laboratory. Delays may occur due to holidays or sample quality issues.

Patient Instructions

1
Before the Test:No fasting or specific preparation is needed. Continue regular medications unless advised otherwise by your doctor. Ensure you are well-hydrated for blood draw.
2
During the Test:The test involves a simple blood draw from your arm. It is quick, typically completed within 5-10 minutes, with minimal discomfort.
3
After the Test:You may experience slight bruising or soreness at the puncture site, which usually resolves quickly. Resume normal activities immediately; no restrictions apply.

About This Test

Who Should Get This Test

The purpose of the IL28B Genotyping Test is to determine the genetic variants at rs12979860 and rs8099917 positions, which are biomarkers for predicting treatment response in hepatitis C patients. This information aids healthcare providers in selecting the most effective therapy, improving treatment outcomes, and assessing the risk of disease progression.

How to Prepare

  • Use a lavender-top (EDTA) tube for blood collection.
  • Ensure proper labeling of the sample with patient details.
  • Mix the blood gently by inverting the tube 8-10 times after collection.
  • Ship the sample refrigerated at 2-8°C; do not freeze.
  • Maintain sample stability as per guidelines: room temperature for 6 hours, refrigerated for 72 hours.

Doctor's Notes

Reviewed by — MBBS, MD (Pathology) · Reg. No. 21521

"This genetic test is essential for personalizing hepatitis C treatment, as IL28B polymorphisms significantly influence patient response to interferon-based therapies, aiding in optimizing treatment plans and improving outcomes."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeWhole blood
Sample Volume3 mL (2 mL min.)
ContainerLavender Top (EDTA) tube
Collection MethodVenipuncture

Sample Stability

Room Temperature: 6 hours
Refrigerated (2-8°C): 72 hours
Frozen: Not applicable (NA)
Sample Rejection Criteria:
  • Sample volume less than 2 mL
  • Clotted, hemolyzed, or improperly stored sample
  • Use of incorrect collection tube (non-EDTA)
  • Sample older than stability limits
  • Unlabeled or mislabeled tubes

Understanding Your Results

Results from the IL28B Genotyping Test provide the genotype at two key SNPs. These genotypes are correlated with the probability of a successful response to hepatitis C treatment, helping to guide therapeutic decisions.
📊

CC at rs12979860

Higher likelihood of sustained virological response (SVR) to interferon-based therapy, often associated with better treatment outcomes.

📊

CT or TT at rs12979860

Reduced likelihood of SVR, indicating potential need for alternative or adjunct therapies.

📊

TT at rs8099917

Higher probability of treatment response, supporting the use of interferon regimens.

📊

TG or GG at rs8099917

Lower response rates, suggesting that direct-acting antivirals may be more appropriate.

⚠️ When to Consult a Doctor:

Consult your healthcare provider if you have been diagnosed with hepatitis C, are considering antiviral treatment, or if the test results indicate a genotype associated with poor response. Discuss how these results may influence your treatment plan and monitor for any liver complications.

Limitations

  • ⚠This test only detects specific IL28B SNPs (rs12979860 and rs8099917) and does not cover all genetic variations.
  • ⚠Results are indicative and should be interpreted in conjunction with clinical history, viral load, and other diagnostic tests.
  • ⚠Effectiveness may vary with different HCV genotypes and treatment regimens (e.g., direct-acting antivirals).
  • ⚠Not a standalone diagnostic for hepatitis C; requires confirmation with antibody or RNA tests.
  • ⚠Genetic factors alone do not determine treatment outcome; other factors like liver fibrosis stage also play a role.

Risks & Considerations

  • ●Minor bruising or hematoma at the blood draw site
  • ●Rare risk of infection or fainting
  • ●Very low risk of excessive bleeding in individuals with clotting disorders

Interfering Factors

  • ●Hemolyzed or clotted blood samples
  • ●Improper sample storage (e.g., freezing when not allowed)
  • ●Contamination during DNA extraction or PCR setup
  • ●Recent blood transfusions may affect DNA composition
  • ●Use of certain anticoagulants not specified (EDTA required)

Compare With Similar Tests

TestInterleukin 28B rs12979860 & rs 8099917 Genotyping Qualitative PCR TestHepatitis C Antibody TestHCV RNA PCR TestHCV Genotyping TestLiver Function Test (LFT)
ComparisonInterleukin 28B rs12979860 & rs 8099917 Genotyping Qualitative PCR Test

Frequently Asked Questions

What is the IL28B Genotyping Test?
This test analyzes genetic variations in the IL28B gene (rs12979860 and rs8099917) to predict how well a patient with hepatitis C may respond to interferon-based treatments.
Why is the IL28B test recommended for hepatitis C patients?
It helps personalize treatment by identifying genetic markers that influence treatment response, allowing doctors to choose the most effective therapy and improve outcomes.
How is the sample collected for this test?
A blood sample of about 3 mL is drawn from a vein in your arm into a lavender-top EDTA tube. Home collection services are available across India.
Is fasting required before the IL28B test?
No, fasting is not required. You can eat and drink normally before the test.
What do the results of this test mean?
Results indicate your genotype at specific IL28B positions; for example, a CC genotype at rs12979860 suggests a higher likelihood of successful treatment response.
How accurate is the IL28B Genotyping Test?
The test uses qualitative PCR, a highly accurate method, but results should be interpreted alongside clinical data by a healthcare provider.
Can this test diagnose hepatitis C?
No, this test does not diagnose hepatitis C; it predicts treatment response. Diagnosis requires antibody or RNA tests to confirm HCV infection.
What is the cost of the IL28B Genotyping Test in India?
The test costs INR 7500, which includes sample collection, analysis, and reporting. Prices may vary slightly by location.
How long does it take to get the test results?
Results are typically available within 2-3 business days after the sample reaches the laboratory.
Is the IL28B test covered by insurance?
Coverage varies by insurance provider and policy. It is often not covered under government schemes like PMJAY; check with your insurer for details.
What are the risks associated with this test?
The test involves a standard blood draw with minimal risks, such as minor bruising or infection at the puncture site, which are rare.
How should I prepare for the IL28B test?
No special preparation is needed. Inform your doctor about any medications and ensure proper hydration before the blood draw.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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