UGT1A1 Gene Crigler-Najjar Syndrome: Symptoms, Diagnosis, and NGS Genetic Test Cost in India
Crigler-Najjar Syndrome is a rare genetic disorder that affects the body’s ability to break down bilirubin, a substance produced during the normal breakdown of red blood cells. The UGT1A1 gene is responsible for producing an enzyme that helps break down bilirubin. In individuals with Crigler-Najjar Syndrome, the UGT1A1 gene is mutated, resulting in a deficiency of the enzyme and an accumulation of bilirubin in the blood.
Symptoms of Crigler-Najjar Syndrome
The symptoms of Crigler-Najjar Syndrome may vary depending on the severity of the condition. Individuals with Crigler-Najjar Syndrome type 1 have a complete absence of the enzyme and experience severe jaundice shortly after birth. This form of the condition is life-threatening and requires immediate medical attention.
Crigler-Najjar Syndrome type 2 is less severe, with individuals having some enzyme activity. Symptoms may develop in childhood or adolescence and can include:
- Yellowing of the skin and eyes
- Abdominal pain
- Dark urine
- Fatigue
Diagnosis of Crigler-Najjar Syndrome
A diagnosis of Crigler-Najjar Syndrome is typically made through blood tests that measure bilirubin levels and liver function. Genetic testing can also be performed to identify mutations in the UGT1A1 gene.
NGS Genetic Test Cost in India
Next-generation sequencing (NGS) is a type of genetic testing that can be used to identify mutations in the UGT1A1 gene. The cost of NGS Genetic Testing for Crigler-Najjar Syndrome in India typically ranges from INR 15,000 to INR 20,000.
NGS testing can be a valuable tool for individuals with a family history of Crigler-Najjar Syndrome or those who are experiencing symptoms of the condition. Early diagnosis can help to prevent complications and improve outcomes.
Conclusion
Crigler-Najjar Syndrome is a rare genetic disorder that can result in severe jaundice and other complications. Genetic testing, including NGS testing, can help to identify mutations in the UGT1A1 gene and provide an early diagnosis. If you or a loved one is experiencing symptoms of Crigler-Najjar Syndrome, it is important to speak with a healthcare provider about testing options.
At DNA Labs India, we offer a range of genetic testing services, including NGS testing for Crigler-Najjar Syndrome. Contact us today to learn more about our services and how we can help you.
| Test Name | UGT1A1 Gene Crigler-Najjar syndrome, type 2 NGS Genetic Test |
|---|---|
| Sample type | Blood or Extracted DNA or One drop Blood on FTA Card |
| Test type | General Physician |
| Pre-test Information | Clinical History of Patient who is going for UGT1A1 Gene Crigler-Najjar syndrome, type 2 NGS Genetic Test. A Genetic Counselling session to draw a pedigree chart of family members affected with UGT1A1 Gene Crigler-Najjar syndrome, type 2 NGS Genetic Test gene UGT1A1 |
| Disease | Hepatology Nephrology Endocrinology Disorders |
| Method | NGS Technology |
| Purpose | NULL |
| Preparation | Ambient Room Temperature |
| Fasting | Clinical History of Patient who is going for UGT1A1 Gene Crigler-Najjar syndrome, type 2 NGS Genetic Test. A Genetic Counselling session to draw a pedigree chart of family members affected with UGT1A1 Gene Crigler-Najjar syndrome, type 2 NGS Genetic Test gene UGT1A1 |
| Get Reports | 3 to 4 Weeks |
| Test Price | INR ₹ 20000 |
Note: We offer free home sample collection for online bookings for UGT1A1 Gene Crigler-Najjar syndrome, type 2 NGS Genetic Test and the test costs a special discounted price of 20000 INR across India. The cities where this service is available include Mumbai, Delhi, Bangalore, Hyderabad, Ahmedabad, Chennai, Kolkata, Surat, Pune, Jaipur, Lucknow, Kanpur, Nagpur, Indore, Thane, Bhopal, Visakhapatnam, Pimpri-Chinchwad, Patna, Vadodara, Ghaziabad, Ludhiana, Agra, Nashik, Faridabad, Meerut, Rajkot, Kalyan-Dombivali, Vasai-Virar, Varanasi, Srinagar, Aurangabad, Dhanbad, Amritsar, Navi Mumbai, Prayagraj, Howrah, Ranchi, Jabalpur, Gwalior, Coimbatore, Vijayawada, Jodhpur, Madurai, Raipur, Kota, Guwahati, Chandigarh, Thiruvananthapuram, Solapur, Hubballi-Dharwad, Tiruchirappalli, Tiruppur, Moradabad, Mysore, Bareily, Gurgaon, Aligarh, Jalandhar, Bhubaneswar, Salem, Mira-Bhayandar, Warangal , Guntur , Bhiwandi, Saharanpur, Gorakhpur, Bikaner, Amravati, Noida, Jamshedpur, Bhilai, Cuttack, Firozabad, Kochi, Nellore , Bhavnagar, Dehradun, Durgapur, Asansol, Rourkela, Nanded, Kolhapur, Ajmer, Akola, Gulbarga, Jamnagar, Ujjain, Loni, Siliguri, Jhansi, Ulhasnagar, Jammu, Sangli-Miraj & Kupwad, Mangalore, Erode10, Belgaum, Ambattur, Tirunelveli, Malegaon, Gaya, Jalgaon, Udaipur, Maheshtala, Davanagere, Kozhikode, Kurnool, Rajpur Sonarpur, Rajahmundry , Bokaro, South Dumdum, Bellary, Patiala, Gopalpur, Agartala, Bhagalpur, Muzaffarnagar, Bhatpara, Panihati, Latur, Dhule, Tirupati , Rohtak, Korba, Bhilwara, Berhampur, Muzaffarpur, Ahmednagar, Mathura, Kollam, Avadi, Kadapa, Kamarhati, Sambalpur, Bilaspur, Shahjahanpur, Satara, Bijapur, Rampur, Shivamogga, Chandrapur, Junagadh, Thrissur, Alwar, Bardhaman, Kulti, Kakinada, Nizamabad, Parbhani, Tumkur, Khammam, Ozhukarai, Bihar Sharif, Panipat, Darbhanga, Bally, Aizawl, Dewas, Ichalkaranji, Karnal, Bathinda, Jalna, Eluru, Kirari Suleman Nagar, Barasat, Purnia, Satna, Mau, Sonipat, Farrukhabad, Sagar, Rourkela, Durg, Imphal, Ratlam, Hapur, Arrah, Karimnagar, Anantapur, Etawah, Ambernath, North Dumdum, Bharatpur, Begusarai, New Delhi, Gandhidham, Baranagar, Tiruvottiyur, Puducherry, Sikar, Thoothukudi, Rewa, Mirzapur, Raichur, Pali, Ramagundam , Haridwar, Vijayanagaram, Katihar, Nagarcoil, Sri Ganganagar, Karawal Nagar, Mango, Thanjavur, Bulandshahr, Uluberia, Murwara, Sambhal, Singrauli, Nadiad, Secunderabad, Naihati, Yamunanagar, Bidhan Nagar, Pallavaram, Bidar, Munger, Panchkula, Burhanpur, Raurkela Industrial Township, Kharagpur, Dindigul, Gandhinagar, Hospet, Nangloi Jat, Malda, Ongole, Deoghar, Chapra, Haldia, Khandwa, Nandyal, Chittoor , Morena, Amroha, Anand, Bhind, Bhalswa Jahangir Pur, Madhyamgram, Bhiwani, Navi Mumbai Panvel Raigad, Baharampur, Ambala, Morvi, Fatehpur, Rae Bareli, Khora, Bhusawal, Orai, Bahraich, Vellore, Mahesana, Sambalpur, Raiganj, Sirsa, Danapur, Serampore, Sultan Pur Majra, Guna, Jaunpur, Panvel, Shivpuri, Surendranagar Dudhrej, Unnao, Hugli and Chinsurah, Alappuzha, Kottayam, Machilipatnam, Shimla, Adoni, Tenali, Proddatur, Saharsa, Hindupur, Sasaram, Hajipur, Bhimavaram, Dehri, Madanapalle, Siwan, Bettiah, Guntakal, Srikakulam, Motihari, Dharmavaram, Gudivada, Narasaraopet, Bagaha, Miryalaguda, Tadipatri, Kishanganj, Karaikudi, Suryapet, Jamalpur, Kavali, Tadepalligudem, Amaravati, Buxar, Jehanabad, Aurangabad.
