MBD5 Gene and Mental Retardation: Everything You Need to Know

Mental retardation, also known as intellectual disability, is a condition characterized by significant limitations in intellectual functioning and adaptive behavior. It affects about 1-3% of the population worldwide, and there are many different causes of mental retardation, including genetic factors.

One gene that has been implicated in mental retardation is the MBD5 gene, which is located on chromosome 2. Mutations in this gene have been associated with a specific type of mental retardation known as autosomal dominant type 1.

What is the MBD5 Gene?

The MBD5 gene provides instructions for making a protein called methyl-CpG-binding domain protein 5 (MBD5). This protein plays a role in regulating gene expression, which is the process by which information in our DNA is used to make proteins and other molecules that are necessary for the body to function properly.

MBD5 is involved in the process of DNA methylation, which is a chemical modification that can turn genes on or off. It is also involved in the development and function of the nervous system, which is why mutations in this gene can lead to mental retardation.

What is Autosomal Dominant Type 1 Mental Retardation?

Autosomal dominant type 1 mental retardation is a specific type of mental retardation that is caused by mutations in the MBD5 gene. It is inherited in an autosomal dominant pattern, which means that an affected individual has a 50% chance of passing the mutation on to each of their children.

This type of mental retardation is characterized by moderate to severe intellectual disability, delayed speech and language development, and behavioral problems such as hyperactivity and aggression. Other features can include seizures, sleep disturbances, and abnormal facial features.

Diagnosis and Testing

Diagnosis of autosomal dominant type 1 mental retardation can be challenging because the symptoms can be similar to other types of mental retardation. However, genetic testing can be used to confirm a diagnosis.

Next-generation sequencing (NGS) is a type of genetic testing that can be used to sequence the entire MBD5 gene and identify any mutations that may be present. This test can be done using a blood or saliva sample, and the results can be used to confirm a diagnosis of autosomal dominant type 1 mental retardation.

The Cost of NGS Genetic Test for MBD5 Gene

The cost of NGS Genetic Test for the MBD5 gene can vary depending on the testing provider and the country where the test is being done. In India, the cost of this test is typically around INR 20,000.

Conclusion

Mutations in the MBD5 gene can lead to a specific type of mental retardation known as autosomal dominant type 1. This condition is characterized by moderate to severe intellectual disability, delayed speech and language development, and behavioral problems. Genetic testing using NGS technology can be used to confirm a diagnosis of this condition, and the cost of this test in India is typically around INR 20,000.

Early diagnosis and intervention can help individuals with mental retardation to reach their full potential, so it is important to seek medical attention if you suspect that you or a loved one may have this condition.

For more information about genetic testing for mental retardation and other genetic conditions, contact DNA Labs India today.

Before getting tested ask for Raw Data, FASTQ, and VCF files along with clinical test report from DNA Testing Lab. DNA Labs India is the Only lab that is transparent and will share Raw Data, FASTQ, and VCF files along with the conclusive clinical report for MBD5 Gene Mental retardation, autosomal dominant type 1 NGS Genetic Test

 Note: We offer free home sample collection for online bookings for MBD5 Gene Mental retardation, autosomal dominant type 1 NGS Genetic Test and the test costs a special discounted price of 20000 INR across India. The cities where this service is available include Mumbai, Delhi, Bangalore, Hyderabad, Ahmedabad, Chennai, Kolkata, Surat, Pune, Jaipur, Lucknow, Kanpur, Nagpur, Indore, Thane, Bhopal, Visakhapatnam, Pimpri-Chinchwad, Patna, Vadodara, Ghaziabad, Ludhiana, Agra, Nashik, Faridabad, Meerut, Rajkot, Kalyan-Dombivali, Vasai-Virar, Varanasi, Srinagar, Aurangabad, Dhanbad, Amritsar, Navi Mumbai, Prayagraj, Howrah, Ranchi, Jabalpur, Gwalior, Coimbatore, Vijayawada, Jodhpur, Madurai, Raipur, Kota, Guwahati, Chandigarh, Thiruvananthapuram, Solapur, Hubballi-Dharwad, Tiruchirappalli, Tiruppur, Moradabad, Mysore, Bareily, Gurgaon, Aligarh, Jalandhar, Bhubaneswar, Salem, Mira-Bhayandar, Warangal , Guntur , Bhiwandi, Saharanpur, Gorakhpur, Bikaner, Amravati, Noida, Jamshedpur, Bhilai, Cuttack, Firozabad, Kochi, Nellore , Bhavnagar, Dehradun, Durgapur, Asansol, Rourkela, Nanded, Kolhapur, Ajmer, Akola, Gulbarga, Jamnagar, Ujjain, Loni, Siliguri, Jhansi, Ulhasnagar, Jammu, Sangli-Miraj & Kupwad, Mangalore, Erode10, Belgaum, Ambattur, Tirunelveli, Malegaon, Gaya, Jalgaon, Udaipur, Maheshtala, Davanagere, Kozhikode, Kurnool, Rajpur Sonarpur, Rajahmundry , Bokaro, South Dumdum, Bellary, Patiala, Gopalpur, Agartala, Bhagalpur, Muzaffarnagar, Bhatpara, Panihati, Latur, Dhule, Tirupati , Rohtak, Korba, Bhilwara, Berhampur, Muzaffarpur, Ahmednagar, Mathura, Kollam, Avadi, Kadapa, Kamarhati, Sambalpur, Bilaspur, Shahjahanpur, Satara, Bijapur, Rampur, Shivamogga, Chandrapur, Junagadh, Thrissur, Alwar, Bardhaman, Kulti, Kakinada, Nizamabad, Parbhani, Tumkur, Khammam, Ozhukarai, Bihar Sharif, Panipat, Darbhanga, Bally, Aizawl, Dewas, Ichalkaranji, Karnal, Bathinda, Jalna, Eluru, Kirari Suleman Nagar, Barasat, Purnia, Satna, Mau, Sonipat, Farrukhabad, Sagar, Rourkela, Durg, Imphal, Ratlam, Hapur, Arrah, Karimnagar, Anantapur, Etawah, Ambernath, North Dumdum, Bharatpur, Begusarai, New Delhi, Gandhidham, Baranagar, Tiruvottiyur, Puducherry, Sikar, Thoothukudi, Rewa, Mirzapur, Raichur, Pali, Ramagundam , Haridwar, Vijayanagaram, Katihar, Nagarcoil, Sri Ganganagar, Karawal Nagar, Mango, Thanjavur, Bulandshahr, Uluberia, Murwara, Sambhal, Singrauli, Nadiad, Secunderabad, Naihati, Yamunanagar, Bidhan Nagar, Pallavaram, Bidar, Munger, Panchkula, Burhanpur, Raurkela Industrial Township, Kharagpur, Dindigul, Gandhinagar, Hospet, Nangloi Jat, Malda, Ongole, Deoghar, Chapra, Haldia, Khandwa, Nandyal, Chittoor , Morena, Amroha, Anand, Bhind, Bhalswa Jahangir Pur, Madhyamgram, Bhiwani, Navi Mumbai Panvel Raigad, Baharampur, Ambala, Morvi, Fatehpur, Rae Bareli, Khora, Bhusawal, Orai, Bahraich, Vellore, Mahesana, Sambalpur, Raiganj, Sirsa, Danapur, Serampore, Sultan Pur Majra, Guna, Jaunpur, Panvel, Shivpuri, Surendranagar Dudhrej, Unnao, Hugli and Chinsurah, Alappuzha, Kottayam, Machilipatnam, Shimla, Adoni, Tenali, Proddatur, Saharsa, Hindupur, Sasaram, Hajipur, Bhimavaram, Dehri, Madanapalle, Siwan, Bettiah, Guntakal, Srikakulam, Motihari, Dharmavaram, Gudivada, Narasaraopet, Bagaha, Miryalaguda, Tadipatri, Kishanganj, Karaikudi, Suryapet, Jamalpur, Kavali, Tadepalligudem, Amaravati, Buxar, Jehanabad, Aurangabad.