MLH3 Gene Colorectal cancer, hereditary nonpolyposis type 7 NGS Genetic Test
Short Name: MLH3 Gene Colorectal Cancer Test
Also known as: HNPCC Type 7 Test, MLH3 Mutation Test, Hereditary Colorectal Cancer Genetic Test
MLH3 Gene Colorectal cancer, hereditary nonpolyposis type 7 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 weeks. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The purpose of this test is to identify mutations in the MLH3 gene that are linked to hereditary colorectal cancer and other associated malignancies. It helps in assessing genetic risk, guiding preventive measures, and informing treatment decisions for individuals and families with a history of cancer.
- Test Code
- 2858
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- 3 to 4 weeks
- Fasting Required
- No
- Method
- Next Generation Sequencing (NGS)
Sample Collection
No specific preparation required. Ensure genetic counseling is completed.
Method: Venipuncture
Laboratory Analysis
A blood sample will be drawn from a vein in the arm.
Report Delivery
Apply pressure to the puncture site to prevent bleeding. Resume normal activities.
Timeline: 3 to 4 weeks
Patient Instructions
About This Test
Who Should Get This Test
The purpose of this test is to identify mutations in the MLH3 gene that are linked to hereditary colorectal cancer and other associated malignancies. It helps in assessing genetic risk, guiding preventive measures, and informing treatment decisions for individuals and families with a history of cancer.
How to Prepare
- No fasting required for this test.
- Bring identification and doctor's prescription.
- Inform the phlebotomist of any medications or health conditions.
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"Genetic testing for MLH3 mutations is crucial for individuals with a family history of colorectal and endometrial cancers, enabling early intervention and personalized management."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed sample
- Insufficient sample volume
- Incorrect sample type
Understanding Your Results
Positive
Pathogenic variant detected in MLH3 gene. Increased risk for colorectal, endometrial, and other cancers. Recommend genetic counseling and enhanced screening.
Negative
No pathogenic variant detected. Risk may be similar to general population, but family history should still be considered.
Variant of Uncertain Significance (VUS)
Genetic variant found but clinical significance unknown. Further testing and family studies may be needed.
Consult a doctor or genetic counselor if you have a family history of cancer, receive a positive test result, or have symptoms suggestive of colorectal cancer.
Limitations
- ⚠This test only detects mutations in the MLH3 gene; other genes associated with hereditary colorectal cancer are not covered.
- ⚠Results may be inconclusive in some cases.
- ⚠Genetic testing does not replace regular cancer screening.
Risks & Considerations
- ●Minimal risk from blood draw: bruising, infection, or fainting
- ●Psychological impact of genetic results
Interfering Factors
- ●Contaminated DNA sample
- ●Improper sample storage
- ●Recent blood transfusion
Frequently Asked Questions
What is the MLH3 Gene Colorectal Cancer NGS Genetic Test?
Who should consider taking this test?
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What is the cost of the MLH3 Gene Test?
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Is home sample collection available for this test?
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Are there any risks associated with the genetic test?
How accurate is the MLH3 Gene Test?
Can this test detect mutations in other genes related to colorectal cancer?
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Related Tests
Reference Laboratory Services
We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
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