Understanding the PFN1 Gene and Amyotrophic Lateral Sclerosis Type 18
Amyotrophic Lateral Sclerosis (ALS), also known as Lou Gehrig’s disease, is a progressive neurodegenerative disorder that affects the nerve cells in the brain and spinal cord. One of the genetic mutations associated with ALS is the PFN1 gene. This gene plays a crucial role in the formation and maintenance of the cytoskeleton of nerve cells, which is essential for proper nerve function.
What is the PFN1 Gene?
The PFN1 gene is responsible for encoding a protein called profilin-1. This protein is involved in the formation and maintenance of the cytoskeleton of nerve cells. The cytoskeleton is a complex network of proteins that gives cells their shape, helps with cell division, and facilitates movement. In nerve cells, the cytoskeleton is essential for the proper transmission of signals between cells.
What is Amyotrophic Lateral Sclerosis Type 18?
Amyotrophic Lateral Sclerosis Type 18 (ALS18) is a rare form of ALS that is caused by mutations in the PFN1 gene. ALS18 is an autosomal dominant disorder, which means that a person only needs to inherit one copy of the mutated gene to develop the disease.
Symptoms of ALS18
The symptoms of ALS18 are similar to those of other forms of ALS, including muscle weakness, stiffness, and twitching. However, ALS18 tends to have a later onset and a slower progression than other forms of the disease.
Diagnosis of ALS18
Diagnosing ALS18 can be challenging, as it is a rare form of the disease. However, genetic testing can help identify mutations in the PFN1 gene that are associated with ALS18. Next-generation sequencing (NGS) is a powerful tool that can quickly and accurately sequence large portions of an individual’s DNA.
Cost of NGS Genetic Test for ALS18
The cost of an NGS Genetic Test for ALS18 in India is around INR 20,000. This test can help identify mutations in the PFN1 gene that are associated with ALS18, which can help with diagnosis and treatment of the disease.
Conclusion
ALS18 is a rare form of ALS that is caused by mutations in the PFN1 gene. Identifying these mutations through genetic testing can help with diagnosis and treatment of the disease. The NGS Genetic Test for ALS18 is available in India at a cost of INR 20,000.
At DNA Labs India, we offer a wide range of genetic testing services, including NGS Genetic Testing for ALS18. Our team of experts uses the latest technology and techniques to provide accurate and reliable results. Contact us today to learn more about our services.
Before getting tested ask for Raw Data, FASTQ, and VCF files along with clinical test report from DNA Testing Lab. DNA Labs India is the Only lab that is transparent and will share Raw Data, FASTQ, and VCF files along with the conclusive clinical report for PFN1 Gene Amyotrophic lateral sclerosis type 18 NGS Genetic Test
| Test Name | PFN1 Gene Amyotrophic Lateral Sclerosis Type 18 NGS Genetic Test |
|---|---|
| Sample type | Blood or Extracted DNA or One drop Blood on FTA Card o |
| Test type | Neurologist |
| Pre-test Information | Clinical History of Patient who is going for PFN1 Gene Amyotrophic lateral sclerosis type 18 NGS Genetic Test A Genetic Counselling session to draw a pedigree chart of family members affected with PFN1 Gene Amyotrophic lateral sclerosis type 18 |
| Disease | Neurological Disorders |
| Method | NGS Technology |
| Purpose | NULL |
| Preparation | Ambient Room Temperature |
| Fasting | Clinical History of Patient who is going for PFN1 Gene Amyotrophic lateral sclerosis type 18 NGS Genetic Test A Genetic Counselling session to draw a pedigree chart of family members affected with PFN1 Gene Amyotrophic lateral sclerosis type 18 |
| Get Reports | 3 to 4 Weeks |
| Test Price | INR ₹ 20000 |
Note: We offer free home sample collection for online bookings for PFN1 Gene Amyotrophic Lateral Sclerosis Type 18 NGS Genetic Test and the test costs a special discounted price of 20000 INR across India. The cities where this service is available include Mumbai, Delhi, Bangalore, Hyderabad, Ahmedabad, Chennai, Kolkata, Surat, Pune, Jaipur, Lucknow, Kanpur, Nagpur, Indore, Thane, Bhopal, Visakhapatnam, Pimpri-Chinchwad, Patna, Vadodara, Ghaziabad, Ludhiana, Agra, Nashik, Faridabad, Meerut, Rajkot, Kalyan-Dombivali, Vasai-Virar, Varanasi, Srinagar, Aurangabad, Dhanbad, Amritsar, Navi Mumbai, Prayagraj, Howrah, Ranchi, Jabalpur, Gwalior, Coimbatore, Vijayawada, Jodhpur, Madurai, Raipur, Kota, Guwahati, Chandigarh, Thiruvananthapuram, Solapur, Hubballi-Dharwad, Tiruchirappalli, Tiruppur, Moradabad, Mysore, Bareily, Gurgaon, Aligarh, Jalandhar, Bhubaneswar, Salem, Mira-Bhayandar, Warangal , Guntur , Bhiwandi, Saharanpur, Gorakhpur, Bikaner, Amravati, Noida, Jamshedpur, Bhilai, Cuttack, Firozabad, Kochi, Nellore , Bhavnagar, Dehradun, Durgapur, Asansol, Rourkela, Nanded, Kolhapur, Ajmer, Akola, Gulbarga, Jamnagar, Ujjain, Loni, Siliguri, Jhansi, Ulhasnagar, Jammu, Sangli-Miraj & Kupwad, Mangalore, Erode10, Belgaum, Ambattur, Tirunelveli, Malegaon, Gaya, Jalgaon, Udaipur, Maheshtala, Davanagere, Kozhikode, Kurnool, Rajpur Sonarpur, Rajahmundry , Bokaro, South Dumdum, Bellary, Patiala, Gopalpur, Agartala, Bhagalpur, Muzaffarnagar, Bhatpara, Panihati, Latur, Dhule, Tirupati , Rohtak, Korba, Bhilwara, Berhampur, Muzaffarpur, Ahmednagar, Mathura, Kollam, Avadi, Kadapa, Kamarhati, Sambalpur, Bilaspur, Shahjahanpur, Satara, Bijapur, Rampur, Shivamogga, Chandrapur, Junagadh, Thrissur, Alwar, Bardhaman, Kulti, Kakinada, Nizamabad, Parbhani, Tumkur, Khammam, Ozhukarai, Bihar Sharif, Panipat, Darbhanga, Bally, Aizawl, Dewas, Ichalkaranji, Karnal, Bathinda, Jalna, Eluru, Kirari Suleman Nagar, Barasat, Purnia, Satna, Mau, Sonipat, Farrukhabad, Sagar, Rourkela, Durg, Imphal, Ratlam, Hapur, Arrah, Karimnagar, Anantapur, Etawah, Ambernath, North Dumdum, Bharatpur, Begusarai, New Delhi, Gandhidham, Baranagar, Tiruvottiyur, Puducherry, Sikar, Thoothukudi, Rewa, Mirzapur, Raichur, Pali, Ramagundam , Haridwar, Vijayanagaram, Katihar, Nagarcoil, Sri Ganganagar, Karawal Nagar, Mango, Thanjavur, Bulandshahr, Uluberia, Murwara, Sambhal, Singrauli, Nadiad, Secunderabad, Naihati, Yamunanagar, Bidhan Nagar, Pallavaram, Bidar, Munger, Panchkula, Burhanpur, Raurkela Industrial Township, Kharagpur, Dindigul, Gandhinagar, Hospet, Nangloi Jat, Malda, Ongole, Deoghar, Chapra, Haldia, Khandwa, Nandyal, Chittoor , Morena, Amroha, Anand, Bhind, Bhalswa Jahangir Pur, Madhyamgram, Bhiwani, Navi Mumbai Panvel Raigad, Baharampur, Ambala, Morvi, Fatehpur, Rae Bareli, Khora, Bhusawal, Orai, Bahraich, Vellore, Mahesana, Sambalpur, Raiganj, Sirsa, Danapur, Serampore, Sultan Pur Majra, Guna, Jaunpur, Panvel, Shivpuri, Surendranagar Dudhrej, Unnao, Hugli and Chinsurah, Alappuzha, Kottayam, Machilipatnam, Shimla, Adoni, Tenali, Proddatur, Saharsa, Hindupur, Sasaram, Hajipur, Bhimavaram, Dehri, Madanapalle, Siwan, Bettiah, Guntakal, Srikakulam, Motihari, Dharmavaram, Gudivada, Narasaraopet, Bagaha, Miryalaguda, Tadipatri, Kishanganj, Karaikudi, Suryapet, Jamalpur, Kavali, Tadepalligudem, Amaravati, Buxar, Jehanabad, Aurangabad.
