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TGFBR2 Gene Colorectal cancer, hereditary nonpolyposis type 6 NGS Genetic Test

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TGFBR2 Gene Colorectal cancer, hereditary nonpolyposis type 6 NGS Genetic Test

Short Name: TGFBR2 Gene NGS Test

Also known as: HNPCC6 Genetic Test, Hereditary Nonpolyposis Colorectal Cancer Type 6 Test, TGFBR2 Mutation Analysis

TGFBR2 Gene Colorectal cancer, hereditary nonpolyposis type 6 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in Results are typically available within 3 to 4 weeks from sample receipt.. Free home collection in 300+ cities across India.

NGS Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

The purpose of the TGFBR2 Gene NGS Genetic Test is to identify pathogenic mutations in the TGFBR2 gene that predispose individuals to hereditary nonpolyposis colorectal cancer type 6 (HNPCC6). This test aids in early diagnosis, risk stratification, and the development of personalized cancer prevention and management strategies for at-risk individuals and families.

Test Code
2859
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
Results are typically available within 3 to 4 weeks from sample receipt.
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

Ensure the patient has provided informed consent and a detailed clinical history. Genetic counseling should be conducted to discuss test implications and draw a pedigree chart of affected family members.

Method: Venipuncture

Step 2

Laboratory Analysis

Collect a blood sample via venipuncture using standard aseptic techniques. Alternatively, use extracted DNA or a blood drop on an FTA card as specified.

Step 3

Report Delivery

Label the sample correctly and transport it to the laboratory under appropriate conditions. Provide post-test counseling and schedule follow-up for result discussion.

Timeline: Results are typically available within 3 to 4 weeks from sample receipt.

Patient Instructions

1
Before the Test:Prior to testing, undergo genetic counseling to understand the implications, provide a detailed family history, and sign informed consent. No specific preparation like fasting is required.
2
During the Test:The test involves a simple blood draw or alternative sample collection. The process is minimally invasive and typically takes a few minutes.
3
After the Test:After sample collection, await results in 3-4 weeks. Genetic counseling will be provided to discuss findings and next steps, including surveillance or preventive measures.

About This Test

Who Should Get This Test

The purpose of the TGFBR2 Gene NGS Genetic Test is to identify pathogenic mutations in the TGFBR2 gene that predispose individuals to hereditary nonpolyposis colorectal cancer type 6 (HNPCC6). This test aids in early diagnosis, risk stratification, and the development of personalized cancer prevention and management strategies for at-risk individuals and families.

How to Prepare

  • Use sterile equipment for blood collection
  • Avoid hemolysis by handling samples gently
  • Store samples at ambient room temperature unless otherwise specified
  • Ensure proper documentation and chain of custody

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"Genetic testing for TGFBR2 mutations is crucial for families with a history of colorectal cancer to assess risk and guide preventive measures, including regular screenings and lifestyle modifications."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample Volume5 mL
ContainerEDTA tube
Collection MethodVenipuncture

Sample Stability

Blood samples: Stable for 48 hours at room temperature
Extracted DNA: Stable for up to 1 week at 4°C or long-term at -20°C
FTA card samples: Stable for months at room temperature
Sample Rejection Criteria:
  • Hemolyzed or clotted blood samples
  • Insufficient sample volume
  • Improperly labeled or contaminated samples
  • Samples without proper consent or documentation

Understanding Your Results

Results from the TGFBR2 Gene NGS Genetic Test should be interpreted in the context of clinical findings and family history. A positive result indicates the presence of a pathogenic mutation, increasing cancer risk, while a negative result suggests no detectable mutations, though residual risk may remain.
📊

Positive for pathogenic variant

Confirms diagnosis of HNPCC6; increased risk for colorectal and other cancers. Recommend enhanced surveillance, genetic counseling, and possible preventive interventions.

📊

Negative for pathogenic variant

No detectable mutations in TGFBR2 gene; does not eliminate hereditary cancer risk if clinical suspicion remains. Consider other genetic tests or continued monitoring.

📊

Variant of uncertain significance (VUS)

Genetic variant detected but clinical significance unknown. Requires further family studies, functional analysis, or periodic re-evaluation.

⚠️ When to Consult a Doctor:

Consult a doctor if you have a family history of colorectal cancer, experience symptoms like persistent changes in bowel habits or blood in the stool, or receive a positive genetic test result for personalized management plans.

Limitations

  • ⚠May not detect all genetic variants, including deep intronic mutations
  • ⚠Requires genetic counseling for proper interpretation of results
  • ⚠Does not replace clinical diagnosis or other diagnostic tests like colonoscopy
  • ⚠Results may have variants of uncertain significance (VUS) requiring further evaluation

Risks & Considerations

  • ●Minimal risk from blood draw, such as bruising or infection
  • ●Psychological impact of genetic results, requiring counseling support
  • ●Potential for variants of uncertain significance causing anxiety

Interfering Factors

  • ●Contaminated or degraded DNA samples
  • ●Improper sample storage or handling
  • ●Recent blood transfusions may affect DNA analysis
  • ●Technical errors in sequencing or data interpretation

Compare With Similar Tests

TestTGFBR2 Gene Colorectal cancer, hereditary nonpolyposis type 6 NGS Genetic TestAPC Gene TestMLH1 Gene TestColorectal Cancer PanelMSH2 Gene Test
ComparisonTGFBR2 Gene Colorectal cancer, hereditary nonpolyposis type 6 NGS Genetic Test

Frequently Asked Questions

What is the TGFBR2 Gene NGS Genetic Test?
It is a next-generation sequencing test that detects mutations in the TGFBR2 gene, associated with hereditary nonpolyposis colorectal cancer type 6 (HNPCC6).
Who should consider this test?
Individuals with a family history of colorectal cancer, symptoms of colorectal cancer, or a personal history of related cancers should consider this test for risk assessment.
What does a positive result mean?
A positive result indicates a pathogenic mutation in TGFBR2, increasing the risk for colorectal and other cancers. It warrants enhanced surveillance and genetic counseling.
What is the cost of the test in India?
The test costs INR 20,000, which includes home sample collection across India.
How is the sample collected?
Samples can be collected via blood draw, extracted DNA, or a blood drop on an FTA card. Home collection is available in many cities.
What is the turnaround time for results?
Results are typically available within 3 to 4 weeks from sample collection.
Is fasting required before the test?
No, fasting is not required for this genetic test.
What are the symptoms of HNPCC6 colorectal cancer?
Symptoms include changes in bowel habits, blood in the stool, abdominal pain, and unexplained weight loss.
Can this test detect all genetic mutations?
No, it may not detect all variants, such as deep intronic mutations. Genetic counseling is recommended for interpretation.
Is genetic counseling provided with the test?
Yes, a genetic counseling session is included to discuss results, draw a pedigree chart, and plan next steps.
What if I have a variant of uncertain significance (VUS)?
A VUS means the clinical significance is unknown. Further family studies or periodic re-evaluation may be needed.
How can I book this test?
You can book online through DNA Labs India's website or contact us via phone or WhatsApp for home sample collection.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

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