NIFTY Non-Invasive Prenatal NIPT Testing
DNA Labs India NIPT or Non-Invasive Prenatal test is performed, analyzed, and supported by DNA Labs India's team of highly experienced laboratory scientists and genetic clinicians at an affordable. DNA Labs India is ranked as India's Most Trusted NIPT Testing facility by doctors and hospitals across India. DNA Labs India is an expert in genetic testing and a global leader in the diagnosis of rare genetic diseases. We conform to the highest standards for diagnostic testing and reporting.
NIPT Test screens for the three most common trisomy conditions present at birth which are:
- Down Syndrome
- Edwards Syndrome
- Patau Syndrome.
Independent validation studies, including the world's largest study on the use of NIPT in clinical practice in nearly 147,000 women, have shown NIPT has an accuracy rate of over 99.99% for the detection of these above conditions. THE TEST CAN ALSO DETECT additional chromosomal abnormalities
- Turner syndrome (Monosomy X)
- Klinefelter syndrome (XXY)
- Jacobs syndrome (XYY)
- Triple X syndrome (XXX)
How does the NIPT work?
Small amounts of a baby's DNA pass into the mother's bloodstream during pregnancy. Cell-free DNA fragments (cfDNA) are short fragments of DNA, which can be found circulating in the mother's blood.
New technology allows us to analyze this DNA directly from the mother's blood and screen for chromosomal abnormalities. cfDNA is then analyzed with our proprietary genetic sequencing technology and bioinformatics pipelines to screen for any chromosomal abnormality in the fetus. If any abnormality is present, small excesses or deficits in counts of the affected chromosome can be detected.
Until recently, it has only been possible to screen for abnormalities with highly invasive procedures such as chorionic villus sampling (CVS) or amniocentesis. These tests carry an elevated risk of miscarriage and are only performed later in pregnancy. Initial screening with NIPT can help to avoid this potentially unnecessary and invasive testing.
There is no risk to the mother or baby, and this test provides the earliest testing available. The technology behind the NIPT test allows for highly accurate results with detection rates for the three most common trisomy conditions present at birth (Down Syndrome, Edwards Syndrome, and Patau Syndrome) over 99%. But it's important to understand that non-invasive prenatal tests such as NIPT Tests are classified as screening tests. This means they do not test with 100% accuracy, such as with an invasive diagnostic procedure such as amniocentesis.
What is NIPT testing?
Our DNA carries all the genetic information we require for normal health and development. It exists in our cells as 23 pairs of chromosomes. During pregnancy, chromosomal abnormalities can arise in the developing baby as a result of incorrect egg or sperm formation, or during the earliest stages of the baby's development. These chromosomal abnormalities can significantly affect a baby's health and well-being, and it is important to identify any abnormalities as early as possible. NIPT delivers a clear positive or negative result for chromosomal abnormalities, where an extra copy of one chromosome is present (Trisomy). Down syndrome, the most common chromosomal abnormality can be detected with an accuracy rate of >99,9%.
When do doctors recommend the test?
- Maternal age 35 years or older at delivery
- Contraindications for invasive prenatal testing, such as placenta prevail, risk of miscarriage, HBV infection, etc.
- History of a prior pregnancy with a chromosomal abnormality
- Fetal ultrasonographic findings indicate an increased risk of T21, T18 or T13
- Requires reassurance following previous screening result
- Received IVF Treatment or has previously suffered from habitual abortion
Sample Required for this testing:
Standard Biological The Non-Invasive Prenatal Testing NIPT Samples: 10 ML Blood
Accuracy of this Test:
The Non-Invasive Prenatal Testing NIPT accuracy is 99%.
Results will take 8-10 working days
NIPT Test cost:
A standard Non-Invasive Prenatal Testing NIPT Blood Testing costs you 10000/- INR, meanwhile, NIPT Twins is 13000 Rs. Alternatively, we provide NIPT Microdeletions is 26000 Rs.
Why Choose DNA Labs India?
DNA labs India's Non-Invasive Prenatal Testing NIPT follows with dual testing for 100% accuracy when determining this Test.
- We are the leading lab for Non-Invasive Prenatal Testing NIPT in India
- Greater Accuracy
- Collection centres across India
- Outstanding customer service
- Strict privacy and confidentiality assured
- Full-service laboratories providing testing for use in complex cases
If NIPT Test is Low-Risk Meaning
A low-risk result on a non-invasive prenatal test (NIPT) means that the test has detected a low probability of certain chromosomal abnormalities or other conditions in the fetus. It is important to note that a low-risk result on a NIPT does not guarantee that the fetus is healthy, as the test is not 100% accurate. Discussing the results of a NIPT with a healthcare provider is always recommended, who can provide more information and guidance on the next steps.
If NIPT Test is Positive
A positive result on a non-invasive prenatal test (NIPT) means that the test has detected an increased probability of a certain chromosomal abnormality or other condition in the fetus. It is important to note that a positive result on a NIPT does not necessarily mean that the fetus has the condition in question, as the test is not 100% accurate. Discussing the results of a NIPT with a healthcare provider is always recommended, who can provide more information and guidance on the next steps, which may include additional testing to confirm the results.
If the NIPT Test is Negative
A negative result on a non-invasive prenatal test (NIPT) means that the test has detected a low probability of certain chromosomal abnormalities or other conditions in the fetus. It is important to note that a negative result on a NIPT does not guarantee that the fetus is healthy, as the test is not 100% accurate. Discussing the results of a NIPT with a healthcare provider is always recommended, who can provide more information and guidance on the next steps.
Difference between Illumina and Ion torrent:
The clinical performance of two massively parallel shotgun sequencing (MPSS) NIPT methods using either an optical NGS technology (Illumina) or a semiconductor NGS technology (Iontorrent ThermoFisher) in high-risk and baseline risk pregnancies for the detection of trisomies 21, 18, 13, and monosomy X. It appears clear from most clinical studies that, for the detection of any of the three main trisomies (T13, T18, and T21), the two index tests do not differ (upper 99% confidence interval limit of the difference) by more than 2.6% in clinical sensitivity, 0.64% in clinical specificity, 0.64% in FPR, and 0.65% in ACC. In terms of PPV and NPV, in high-risk pregnancies, index tests differed by less than 6.41% for PPV and 0.33% for NPV. In pregnancies with baseline risk, only the NPV could be reliably estimated and it did not differ (upper 99% confidence interval limit of the difference) by more than 0.33% between the two index tests.