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Accurate Test Results for Thiopurine Methyltransferase (TPMT - *2, *3A, *3B, *3C) Genotyping
Thiopurine Methyltransferase (TPMT - *2, *3A, *3B, *3C) Genotyping Cost 6000 Rs
Thiopurine Methyltransferase (TPMT - *2, *3A, *3B, *3C) Genotyping Details
Thiopurine Methyltransferase (TPMT - *2, *3A, *3B, *3C) Genotyping Cost INR:6000 Symptoms Diagnosis
DNA Labs India offers Thiopurine Methyltransferase (TPMT) genotyping at a cost of INR 6000. This test helps in determining the genetic makeup of an individual's TPMT enzyme, which plays a crucial role in the metabolism of thiopurine drugs. The test identifies the presence of *2, *3A, *3B, *3C variants of the TPMT gene, which are associated with different levels of TPMT enzyme activity. The results of this test can help healthcare professionals in prescribing the right dose of thiopurine drugs, reducing the risk of side effects and improving treatment outcomes.
What is Thiopurine Methyltransferase (TPMT)?
Thiopurine Methyltransferase (TPMT) is an enzyme that plays a crucial role in the metabolism of thiopurine drugs, which are used in the treatment of various autoimmune disorders, inflammatory bowel disease, and leukemia. Thiopurine drugs, such as azathioprine and 6-mercaptopurine, are metabolized by TPMT into inactive metabolites, which are then excreted from the body. The level of TPMT enzyme activity varies among individuals, and genetic variations in the TPMT gene can affect the level of enzyme activity.
Why is TPMT Genotyping Important?
TPMT genotyping is important because it helps in determining an individual's TPMT enzyme activity level, which is crucial in prescribing the right dose of thiopurine drugs. Individuals with low TPMT enzyme activity are at a higher risk of side effects, such as bone marrow suppression, liver toxicity, and infections, when treated with standard doses of thiopurine drugs. On the other hand, individuals with high TPMT enzyme activity may require higher doses of thiopurine drugs to achieve therapeutic benefits.
What are the Symptoms of TPMT Deficiency?
TPMT deficiency can lead to an increased risk of side effects when treated with thiopurine drugs. Some of the symptoms associated with TPMT deficiency include:
- Fever
- Fatigue
- Nausea
- Vomiting
- Jaundice
- Abdominal pain
- Bone marrow suppression
- Infections
- Liver toxicity
How is TPMT Genotyping Done?
TPMT genotyping is done using a small blood sample. The DNA from the blood sample is extracted and analyzed for the presence of *2, *3A, *3B, *3C variants of the TPMT gene using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) techniques. The results of the test are reported as either wild type, heterozygous, or homozygous for the different TPMT gene variants.
Conclusion
Thiopurine Methyltransferase (TPMT) genotyping is an important test that can help healthcare professionals in prescribing the right dose of thiopurine drugs, reducing the risk of side effects, and improving treatment outcomes. DNA Labs India offers TPMT genotyping at a cost of INR 6000. The test identifies the presence of *2, *3A, *3B, *3C variants of the TPMT gene, which are associated with different levels of TPMT enzyme activity. If you are being treated with thiopurine drugs, talk to your healthcare professional about the benefits of TPMT genotyping.
