LOXL1 Gene and Exfoliation Syndrome: Symptoms, Diagnosis, and DNA Testing
Exfoliation syndrome is an eye disorder that affects millions of people worldwide. It occurs when abnormal deposits of fibrillar material accumulate in the eye, leading to increased intraocular pressure and eventually to glaucoma. While the exact cause of exfoliation syndrome is not known, recent studies have identified a genetic link, specifically with the LOXL1 gene.
The LOXL1 Gene and Exfoliation Syndrome
The LOXL1 gene is responsible for producing an enzyme that helps to maintain the structural integrity of the eye’s extracellular matrix. Research has shown that certain variations in this gene are associated with an increased risk of exfoliation syndrome and subsequent glaucoma.
According to a study published in the Journal of Glaucoma, individuals who carry the “risk” variants of the LOXL1 gene are up to 20 times more likely to develop exfoliation syndrome than those who do not have these variants. This highlights the importance of genetic testing for individuals with a family history of the condition or those who may be at risk due to other factors.
Symptoms of Exfoliation Syndrome
Exfoliation syndrome is often asymptomatic in its early stages, which is why regular eye exams are crucial for early detection and treatment. However, as the condition progresses, symptoms may include:
- Increased intraocular pressure
- Blurred vision
- Sensitivity to light
- Glare
- Halos around lights
- Difficulty seeing in low light conditions
Diagnosis of Exfoliation Syndrome
Diagnosing exfoliation syndrome typically involves a comprehensive eye exam, which may include:
- Measuring intraocular pressure
- Examining the optic nerve
- Assessing the health of the retina
- Checking for signs of abnormal deposits on the lens or iris
In some cases, additional testing may be necessary to rule out other eye conditions or to determine the best course of treatment.
DNA Testing for Exfoliation Syndrome
Genetic testing can be a valuable tool in identifying individuals who may be at increased risk for exfoliation syndrome due to their LOXL1 gene variants. Next-generation sequencing (NGS) is a state-of-the-art DNA testing technology that can analyze a large number of genes simultaneously, including the LOXL1 gene.
At DNA Labs India, we offer NGS-based genetic testing for exfoliation syndrome at an affordable cost of INR 20,000. Our test can help identify the specific LOXL1 gene variants that may be contributing to an individual’s risk for the condition. This information can be used to inform screening, prevention, and treatment strategies.
Conclusion
Exfoliation syndrome is a serious eye condition that can lead to vision loss and blindness if left untreated. Genetic testing can be a valuable tool in identifying individuals who may be at increased risk for the condition, particularly those with a family history or other risk factors. With our NGS-based genetic testing for exfoliation syndrome, DNA Labs India is committed to helping individuals take control of their eye health and make informed decisions about their care.
Don’t wait until it’s too late. Contact DNA Labs India today to learn more about our genetic testing services for exfoliation syndrome.
Before getting tested ask for Raw Data, FASTQ, and VCF files along with clinical test report from DNA Testing Lab. DNA Labs India is the Only lab that is transparent and will share Raw Data, FASTQ, and VCF files along with the conclusive clinical report for LOXL1 Gene Exfoliation syndrome, susceptibility to NGS Genetic Test
| Test Name | LOXL1 Gene Exfoliation Syndrome, Susceptibility to NGS Genetic Test |
|---|---|
| Sample type | Blood or Extracted DNA or One drop Blood on FTA Card |
| Test type | Ophthalmologist |
| Pre-test Information | Clinical History of Patient who is going for LOXL1 Gene Exfoliation syndrome, susceptibility to NGS Genetic Test. A Genetic Counselling session to draw a pedigree chart of family members affected with LOXL1 Gene Exfoliation syndrome, susceptibility to NGS Genetic Test gene LOXL1 |
| Disease | Ophthalmology Disorders |
| Method | NGS Technology |
| Purpose | NULL |
| Preparation | Ambient Room Temperature |
| Fasting | Clinical History of Patient who is going for LOXL1 Gene Exfoliation syndrome, susceptibility to NGS Genetic Test. A Genetic Counselling session to draw a pedigree chart of family members affected with LOXL1 Gene Exfoliation syndrome, susceptibility to NGS Genetic Test gene LOXL1 |
| Get Reports | 3 to 4 Weeks |
| Test Price | INR ₹ 20000 |
Note: We offer free home sample collection for online bookings for LOXL1 Gene Exfoliation Syndrome, Susceptibility to NGS Genetic Test and the test costs a special discounted price of 20000 INR across India. The cities where this service is available include Mumbai, Delhi, Bangalore, Hyderabad, Ahmedabad, Chennai, Kolkata, Surat, Pune, Jaipur, Lucknow, Kanpur, Nagpur, Indore, Thane, Bhopal, Visakhapatnam, Pimpri-Chinchwad, Patna, Vadodara, Ghaziabad, Ludhiana, Agra, Nashik, Faridabad, Meerut, Rajkot, Kalyan-Dombivali, Vasai-Virar, Varanasi, Srinagar, Aurangabad, Dhanbad, Amritsar, Navi Mumbai, Prayagraj, Howrah, Ranchi, Jabalpur, Gwalior, Coimbatore, Vijayawada, Jodhpur, Madurai, Raipur, Kota, Guwahati, Chandigarh, Thiruvananthapuram, Solapur, Hubballi-Dharwad, Tiruchirappalli, Tiruppur, Moradabad, Mysore, Bareily, Gurgaon, Aligarh, Jalandhar, Bhubaneswar, Salem, Mira-Bhayandar, Warangal , Guntur , Bhiwandi, Saharanpur, Gorakhpur, Bikaner, Amravati, Noida, Jamshedpur, Bhilai, Cuttack, Firozabad, Kochi, Nellore , Bhavnagar, Dehradun, Durgapur, Asansol, Rourkela, Nanded, Kolhapur, Ajmer, Akola, Gulbarga, Jamnagar, Ujjain, Loni, Siliguri, Jhansi, Ulhasnagar, Jammu, Sangli-Miraj & Kupwad, Mangalore, Erode10, Belgaum, Ambattur, Tirunelveli, Malegaon, Gaya, Jalgaon, Udaipur, Maheshtala, Davanagere, Kozhikode, Kurnool, Rajpur Sonarpur, Rajahmundry , Bokaro, South Dumdum, Bellary, Patiala, Gopalpur, Agartala, Bhagalpur, Muzaffarnagar, Bhatpara, Panihati, Latur, Dhule, Tirupati , Rohtak, Korba, Bhilwara, Berhampur, Muzaffarpur, Ahmednagar, Mathura, Kollam, Avadi, Kadapa, Kamarhati, Sambalpur, Bilaspur, Shahjahanpur, Satara, Bijapur, Rampur, Shivamogga, Chandrapur, Junagadh, Thrissur, Alwar, Bardhaman, Kulti, Kakinada, Nizamabad, Parbhani, Tumkur, Khammam, Ozhukarai, Bihar Sharif, Panipat, Darbhanga, Bally, Aizawl, Dewas, Ichalkaranji, Karnal, Bathinda, Jalna, Eluru, Kirari Suleman Nagar, Barasat, Purnia, Satna, Mau, Sonipat, Farrukhabad, Sagar, Rourkela, Durg, Imphal, Ratlam, Hapur, Arrah, Karimnagar, Anantapur, Etawah, Ambernath, North Dumdum, Bharatpur, Begusarai, New Delhi, Gandhidham, Baranagar, Tiruvottiyur, Puducherry, Sikar, Thoothukudi, Rewa, Mirzapur, Raichur, Pali, Ramagundam , Haridwar, Vijayanagaram, Katihar, Nagarcoil, Sri Ganganagar, Karawal Nagar, Mango, Thanjavur, Bulandshahr, Uluberia, Murwara, Sambhal, Singrauli, Nadiad, Secunderabad, Naihati, Yamunanagar, Bidhan Nagar, Pallavaram, Bidar, Munger, Panchkula, Burhanpur, Raurkela Industrial Township, Kharagpur, Dindigul, Gandhinagar, Hospet, Nangloi Jat, Malda, Ongole, Deoghar, Chapra, Haldia, Khandwa, Nandyal, Chittoor , Morena, Amroha, Anand, Bhind, Bhalswa Jahangir Pur, Madhyamgram, Bhiwani, Navi Mumbai Panvel Raigad, Baharampur, Ambala, Morvi, Fatehpur, Rae Bareli, Khora, Bhusawal, Orai, Bahraich, Vellore, Mahesana, Sambalpur, Raiganj, Sirsa, Danapur, Serampore, Sultan Pur Majra, Guna, Jaunpur, Panvel, Shivpuri, Surendranagar Dudhrej, Unnao, Hugli and Chinsurah, Alappuzha, Kottayam, Machilipatnam, Shimla, Adoni, Tenali, Proddatur, Saharsa, Hindupur, Sasaram, Hajipur, Bhimavaram, Dehri, Madanapalle, Siwan, Bettiah, Guntakal, Srikakulam, Motihari, Dharmavaram, Gudivada, Narasaraopet, Bagaha, Miryalaguda, Tadipatri, Kishanganj, Karaikudi, Suryapet, Jamalpur, Kavali, Tadepalligudem, Amaravati, Buxar, Jehanabad, Aurangabad.
