DLG3 Gene and Mental Retardation: Understanding X-Linked Type 90 NGS Genetic Test
Mental retardation is a neurodevelopmental disorder characterized by impaired cognitive abilities and adaptive functioning. It affects about 1-3% of the population worldwide, and there are different types and causes of mental retardation.
One of the genetic causes of mental retardation is the DLG3 gene, which is located on the X chromosome. Mutations in this gene can cause X-linked mental retardation type 90 (MRX90), a condition that affects mainly males.
What is the DLG3 Gene?
The DLG3 gene (also known as SAP102) encodes a protein called discs large homolog 3, which is involved in the formation and function of synapses, the connections between neurons in the brain. Synapses are essential for learning and memory, and their dysfunction can lead to cognitive impairment.
DLG3 mutations can disrupt the normal function of synapses, leading to mental retardation and other neurological symptoms.
What are the Symptoms of X-Linked Type 90 Mental Retardation?
X-linked mental retardation type 90 is a rare condition that affects mainly males. The severity of the symptoms can vary from mild to severe, and some affected individuals may have only subtle cognitive impairments.
Some of the common symptoms of MRX90 include:
- Intellectual disability
- Speech and language delays
- Behavioral problems
- Autism spectrum disorder
- Seizures
- Motor coordination problems
- Hypotonia (low muscle tone)
These symptoms may appear in early childhood or later in life, depending on the severity of the mutation and other genetic and environmental factors.
How is X-Linked Type 90 Mental Retardation Diagnosed?
X-linked mental retardation type 90 can be diagnosed through genetic testing, specifically Next-Generation Sequencing (NGS) DNA testing. NGS is a high-throughput method that allows the sequencing of multiple genes simultaneously, making it a cost-effective and time-efficient way to diagnose genetic disorders.
The genetic test for MRX90 involves analyzing the DLG3 gene for mutations or variations that may affect its function. The test can be performed on a blood or saliva sample, and the results can usually be obtained within a few weeks.
What is the Cost of X-Linked Type 90 NGS Genetic Test in India?
The cost of genetic testing in India can vary depending on the laboratory and the specific test required. The cost of X-linked mental retardation type 90 NGS Genetic Test in India is typically around INR 20,000.
However, it is important to note that genetic testing may not be covered by insurance, and some laboratories may charge additional fees for sample collection, shipping, and interpretation of results.
Conclusion
X-linked mental retardation type 90 is a rare genetic disorder caused by mutations in the DLG3 gene. It can lead to cognitive impairment, speech and language delays, behavioral problems, and other neurological symptoms. Genetic testing, specifically NGS DNA testing, can help diagnose the condition and provide valuable information for treatment and management. The cost of genetic testing in India may vary, but it is an important investment in the health and well-being of affected individuals and their families.
| Test Name | DLG3 Gene Mental retardation, X-linked type 90 NGS Genetic Test |
|---|---|
| Sample type | Blood or Extracted DNA or One drop Blood on FTA Card o |
| Test type | Neurologist |
| Pre-test Information | Clinical History of Patient who is going for DLG3 Gene Mental retardation, X-linked type 90 NGS Genetic Test A Genetic Counselling session to draw a pedigree chart of family members affected with DLG3 Gene Mental retardation, X-linked type 90 |
| Disease | Neurological Disorders |
| Method | NGS Technology |
| Purpose | NULL |
| Preparation | Ambient Room Temperature |
| Fasting | Clinical History of Patient who is going for DLG3 Gene Mental retardation, X-linked type 90 NGS Genetic Test A Genetic Counselling session to draw a pedigree chart of family members affected with DLG3 Gene Mental retardation, X-linked type 90 |
| Get Reports | 3 to 4 Weeks |
| Test Price | INR ₹ 20000 |
Note: We offer free home sample collection for online bookings for DLG3 Gene Mental retardation, X-linked type 90 NGS Genetic Test and the test costs a special discounted price of 20000 INR across India. The cities where this service is available include Mumbai, Delhi, Bangalore, Hyderabad, Ahmedabad, Chennai, Kolkata, Surat, Pune, Jaipur, Lucknow, Kanpur, Nagpur, Indore, Thane, Bhopal, Visakhapatnam, Pimpri-Chinchwad, Patna, Vadodara, Ghaziabad, Ludhiana, Agra, Nashik, Faridabad, Meerut, Rajkot, Kalyan-Dombivali, Vasai-Virar, Varanasi, Srinagar, Aurangabad, Dhanbad, Amritsar, Navi Mumbai, Prayagraj, Howrah, Ranchi, Jabalpur, Gwalior, Coimbatore, Vijayawada, Jodhpur, Madurai, Raipur, Kota, Guwahati, Chandigarh, Thiruvananthapuram, Solapur, Hubballi-Dharwad, Tiruchirappalli, Tiruppur, Moradabad, Mysore, Bareily, Gurgaon, Aligarh, Jalandhar, Bhubaneswar, Salem, Mira-Bhayandar, Warangal , Guntur , Bhiwandi, Saharanpur, Gorakhpur, Bikaner, Amravati, Noida, Jamshedpur, Bhilai, Cuttack, Firozabad, Kochi, Nellore , Bhavnagar, Dehradun, Durgapur, Asansol, Rourkela, Nanded, Kolhapur, Ajmer, Akola, Gulbarga, Jamnagar, Ujjain, Loni, Siliguri, Jhansi, Ulhasnagar, Jammu, Sangli-Miraj & Kupwad, Mangalore, Erode10, Belgaum, Ambattur, Tirunelveli, Malegaon, Gaya, Jalgaon, Udaipur, Maheshtala, Davanagere, Kozhikode, Kurnool, Rajpur Sonarpur, Rajahmundry , Bokaro, South Dumdum, Bellary, Patiala, Gopalpur, Agartala, Bhagalpur, Muzaffarnagar, Bhatpara, Panihati, Latur, Dhule, Tirupati , Rohtak, Korba, Bhilwara, Berhampur, Muzaffarpur, Ahmednagar, Mathura, Kollam, Avadi, Kadapa, Kamarhati, Sambalpur, Bilaspur, Shahjahanpur, Satara, Bijapur, Rampur, Shivamogga, Chandrapur, Junagadh, Thrissur, Alwar, Bardhaman, Kulti, Kakinada, Nizamabad, Parbhani, Tumkur, Khammam, Ozhukarai, Bihar Sharif, Panipat, Darbhanga, Bally, Aizawl, Dewas, Ichalkaranji, Karnal, Bathinda, Jalna, Eluru, Kirari Suleman Nagar, Barasat, Purnia, Satna, Mau, Sonipat, Farrukhabad, Sagar, Rourkela, Durg, Imphal, Ratlam, Hapur, Arrah, Karimnagar, Anantapur, Etawah, Ambernath, North Dumdum, Bharatpur, Begusarai, New Delhi, Gandhidham, Baranagar, Tiruvottiyur, Puducherry, Sikar, Thoothukudi, Rewa, Mirzapur, Raichur, Pali, Ramagundam , Haridwar, Vijayanagaram, Katihar, Nagarcoil, Sri Ganganagar, Karawal Nagar, Mango, Thanjavur, Bulandshahr, Uluberia, Murwara, Sambhal, Singrauli, Nadiad, Secunderabad, Naihati, Yamunanagar, Bidhan Nagar, Pallavaram, Bidar, Munger, Panchkula, Burhanpur, Raurkela Industrial Township, Kharagpur, Dindigul, Gandhinagar, Hospet, Nangloi Jat, Malda, Ongole, Deoghar, Chapra, Haldia, Khandwa, Nandyal, Chittoor , Morena, Amroha, Anand, Bhind, Bhalswa Jahangir Pur, Madhyamgram, Bhiwani, Navi Mumbai Panvel Raigad, Baharampur, Ambala, Morvi, Fatehpur, Rae Bareli, Khora, Bhusawal, Orai, Bahraich, Vellore, Mahesana, Sambalpur, Raiganj, Sirsa, Danapur, Serampore, Sultan Pur Majra, Guna, Jaunpur, Panvel, Shivpuri, Surendranagar Dudhrej, Unnao, Hugli and Chinsurah, Alappuzha, Kottayam, Machilipatnam, Shimla, Adoni, Tenali, Proddatur, Saharsa, Hindupur, Sasaram, Hajipur, Bhimavaram, Dehri, Madanapalle, Siwan, Bettiah, Guntakal, Srikakulam, Motihari, Dharmavaram, Gudivada, Narasaraopet, Bagaha, Miryalaguda, Tadipatri, Kishanganj, Karaikudi, Suryapet, Jamalpur, Kavali, Tadepalligudem, Amaravati, Buxar, Jehanabad, Aurangabad.
