CASP8 Gene Autoimmune Lymphoproliferative Syndrome Type 2B NGS Genetic Test
Autoimmune lymphoproliferative syndrome (ALPS) is a rare genetic disorder that affects the immune system. It is caused by mutations in genes that regulate the apoptosis (cell death) of immune cells. ALPS can lead to the accumulation of abnormal lymphocytes in the body, which can cause autoimmune disorders, such as autoimmune hemolytic anemia, thrombocytopenia, and neutropenia.
CASP8 gene is one of the genes that are associated with ALPS. The CASP8 gene provides instructions for making a protein called caspase-8, which is involved in the apoptosis of immune cells. Mutations in the CASP8 gene can result in the abnormal survival of immune cells, leading to the development of ALPS type 2B.
Symptoms of ALPS Type 2B
The symptoms of ALPS type 2B may vary from person to person. Some of the common symptoms include:
- Recurrent infections
- Enlarged lymph nodes, liver, and spleen
- Anemia
- Thrombocytopenia
- Neutropenia
- Prolonged fever
- Autoimmune disorders, such as autoimmune hemolytic anemia, immune thrombocytopenic purpura, and autoimmune neutropenia
Diagnosis of ALPS Type 2B
ALPS type 2B can be diagnosed through genetic testing. Next-generation sequencing (NGS) Genetic Test can be used to detect mutations in the CASP8 gene. NGS is a high-throughput method that can analyze multiple genes at the same time, making it a cost-effective and efficient way to diagnose ALPS type 2B.
The NGS Genetic Test for ALPS type 2B typically costs around INR 20,000 in India.
Conclusion
ALPS type 2B is a rare genetic disorder that affects the immune system. It is caused by mutations in the CASP8 gene, which regulates the apoptosis of immune cells. The symptoms of ALPS type 2B may vary, but they often include recurrent infections, enlarged lymph nodes, and autoimmune disorders. NGS Genetic Test can be used to diagnose ALPS type 2B, and it typically costs around INR 20,000 in India.
If you suspect that you or a loved one may have ALPS type 2B, consult a genetic counselor or a healthcare professional for further evaluation and testing.
| Test Name | CASP8 Gene Autoimmune lymphoproliferative syndrome type 2B NGS Genetic Test |
|---|---|
| Sample type | Blood or Extracted DNA or One drop Blood on FTA Card |
| Test type | Dermatologist |
| Pre-test Information | Clinical History of Patient who is going for CASP8 Gene Autoimmune lymphoproliferative syndrome type 2B NGS Genetic Test. A Genetic Counselling session to draw a pedigree chart of family members affected with CASP8 Gene Autoimmune lymphoproliferative syndrome type 2B NGS Genetic Test gene CASP8 |
| Disease | Osteology Dermatology Immunology Disorders |
| Method | NGS Technology |
| Purpose | NULL |
| Preparation | Ambient Room Temperature |
| Fasting | Clinical History of Patient who is going for CASP8 Gene Autoimmune lymphoproliferative syndrome type 2B NGS Genetic Test. A Genetic Counselling session to draw a pedigree chart of family members affected with CASP8 Gene Autoimmune lymphoproliferative syndrome type 2B NGS Genetic Test gene CASP8 |
| Get Reports | 3 to 4 Weeks |
| Test Price | INR ₹ 20000 |
Note: We offer free home sample collection for online bookings for CASP8 Gene Autoimmune lymphoproliferative syndrome type 2B NGS Genetic Test and the test costs a special discounted price of 20000 INR across India. The cities where this service is available include Mumbai, Delhi, Bangalore, Hyderabad, Ahmedabad, Chennai, Kolkata, Surat, Pune, Jaipur, Lucknow, Kanpur, Nagpur, Indore, Thane, Bhopal, Visakhapatnam, Pimpri-Chinchwad, Patna, Vadodara, Ghaziabad, Ludhiana, Agra, Nashik, Faridabad, Meerut, Rajkot, Kalyan-Dombivali, Vasai-Virar, Varanasi, Srinagar, Aurangabad, Dhanbad, Amritsar, Navi Mumbai, Prayagraj, Howrah, Ranchi, Jabalpur, Gwalior, Coimbatore, Vijayawada, Jodhpur, Madurai, Raipur, Kota, Guwahati, Chandigarh, Thiruvananthapuram, Solapur, Hubballi-Dharwad, Tiruchirappalli, Tiruppur, Moradabad, Mysore, Bareily, Gurgaon, Aligarh, Jalandhar, Bhubaneswar, Salem, Mira-Bhayandar, Warangal , Guntur , Bhiwandi, Saharanpur, Gorakhpur, Bikaner, Amravati, Noida, Jamshedpur, Bhilai, Cuttack, Firozabad, Kochi, Nellore , Bhavnagar, Dehradun, Durgapur, Asansol, Rourkela, Nanded, Kolhapur, Ajmer, Akola, Gulbarga, Jamnagar, Ujjain, Loni, Siliguri, Jhansi, Ulhasnagar, Jammu, Sangli-Miraj & Kupwad, Mangalore, Erode10, Belgaum, Ambattur, Tirunelveli, Malegaon, Gaya, Jalgaon, Udaipur, Maheshtala, Davanagere, Kozhikode, Kurnool, Rajpur Sonarpur, Rajahmundry , Bokaro, South Dumdum, Bellary, Patiala, Gopalpur, Agartala, Bhagalpur, Muzaffarnagar, Bhatpara, Panihati, Latur, Dhule, Tirupati , Rohtak, Korba, Bhilwara, Berhampur, Muzaffarpur, Ahmednagar, Mathura, Kollam, Avadi, Kadapa, Kamarhati, Sambalpur, Bilaspur, Shahjahanpur, Satara, Bijapur, Rampur, Shivamogga, Chandrapur, Junagadh, Thrissur, Alwar, Bardhaman, Kulti, Kakinada, Nizamabad, Parbhani, Tumkur, Khammam, Ozhukarai, Bihar Sharif, Panipat, Darbhanga, Bally, Aizawl, Dewas, Ichalkaranji, Karnal, Bathinda, Jalna, Eluru, Kirari Suleman Nagar, Barasat, Purnia, Satna, Mau, Sonipat, Farrukhabad, Sagar, Rourkela, Durg, Imphal, Ratlam, Hapur, Arrah, Karimnagar, Anantapur, Etawah, Ambernath, North Dumdum, Bharatpur, Begusarai, New Delhi, Gandhidham, Baranagar, Tiruvottiyur, Puducherry, Sikar, Thoothukudi, Rewa, Mirzapur, Raichur, Pali, Ramagundam , Haridwar, Vijayanagaram, Katihar, Nagarcoil, Sri Ganganagar, Karawal Nagar, Mango, Thanjavur, Bulandshahr, Uluberia, Murwara, Sambhal, Singrauli, Nadiad, Secunderabad, Naihati, Yamunanagar, Bidhan Nagar, Pallavaram, Bidar, Munger, Panchkula, Burhanpur, Raurkela Industrial Township, Kharagpur, Dindigul, Gandhinagar, Hospet, Nangloi Jat, Malda, Ongole, Deoghar, Chapra, Haldia, Khandwa, Nandyal, Chittoor , Morena, Amroha, Anand, Bhind, Bhalswa Jahangir Pur, Madhyamgram, Bhiwani, Navi Mumbai Panvel Raigad, Baharampur, Ambala, Morvi, Fatehpur, Rae Bareli, Khora, Bhusawal, Orai, Bahraich, Vellore, Mahesana, Sambalpur, Raiganj, Sirsa, Danapur, Serampore, Sultan Pur Majra, Guna, Jaunpur, Panvel, Shivpuri, Surendranagar Dudhrej, Unnao, Hugli and Chinsurah, Alappuzha, Kottayam, Machilipatnam, Shimla, Adoni, Tenali, Proddatur, Saharsa, Hindupur, Sasaram, Hajipur, Bhimavaram, Dehri, Madanapalle, Siwan, Bettiah, Guntakal, Srikakulam, Motihari, Dharmavaram, Gudivada, Narasaraopet, Bagaha, Miryalaguda, Tadipatri, Kishanganj, Karaikudi, Suryapet, Jamalpur, Kavali, Tadepalligudem, Amaravati, Buxar, Jehanabad, Aurangabad.
