Karyotyping:
Karyotyping is a technique to grow chromosomes, while karyotype is a method or procedure to arrange it using either manual method or computational software. Karyotype analysis is a culture-based technique whereby new viable tissue cells are grown and arrested in the metaphase stage of cell division.
A karyotype is the unique language of cytogenetics that translates what is analytically observed from multiple cells of a specimen into a universally understood string of alphanumeric symbols. The sex chromosomes are generally placed at the end of a karyogram.
The nucleus is dissolved, and the chromosomes are banded using various staining techniques and subsequently evaluated for numerical and gross abnormalities including aberrations in chromosome copy numbers (aneuploidies) as well as chromosomal translocations, segmental deletions, and inversions.
Conventional karyotyping is most useful for detecting congenital genetic diseases and is often used in conjunction with medical autopsies of stillborns. Spectral karyotyping is a sophisticated and most recent optimization of the traditional methods in which every chromosomal pair is coloured with different dyes.
How Is the Karyotype Test Done?
The test can be performed on almost any tissue, including:
- Amniotic fluid
- Blood
- Bone marrow
For infertile couples, the test is usually done via a blood draw, from both the male and female partner. The blood samples are then processed in a lab. A karyotype is a test to identify and evaluate the size, shape, and number of chromosomes in a sample of body cells.
Cells from the blood sample are placed in a particular container to encourage them to grow. Once the cells reach a specific stage of growth, the cells are stained and studied under a microscope.
Karyotype tests will see if any of these have happened with your baby. The most common things doctors look for with karyotype tests include: A baby has an extra, or third, chromosome 21. Karyotype tests can be used for more than finding birth defects.
What is the cost of Karyotyping Test?
| Karyotyping Test | Test Cost |
| Karyotyping Test for Single | Rs.4000 |
| Karyotyping Test for Couple | Rs.7600 |
| Fragile X Karyotyping | Rs.8000 |
| Karyotyping for Products of Conception | Rs.6000 |
How much time does it take for the outcome of the results?
It takes 8-10 working days for the outcome of the results. The results will be sent to your email.
How to book an appointment for Karyotyping Test?
You can either book the test online or can call us to book your test, and a free home sample collection will be provided to all our clients.
Why is the Karyotyping test performed?
This test is usually done to evaluate a couple with a history of miscarriages or to examine any child or baby who has unusual features or developmental delays that suggest a genetic abnormality.
The bone marrow or blood test can be done to identify the Philadelphia chromosome, which is found in about 85% of people with chronic myelogenous leukaemia (CML). The amniotic fluid test is done to check a developing fetus for chromosome abnormalities.
An unusual number of chromosomes, incorrectly arranged chromosomes, or malformed chromosomes can all be signs of a genetic condition. Genetic conditions vary greatly, but two examples are Down syndrome, and Turner syndrome Karyotyping can be used to detect a variety of genetic disorders.
Babies can be karyotype tested before they’re born to diagnose genetic abnormalities that indicate severe congenital disabilities, such as Klinefelter syndrome. In Klinefelter syndrome, a boy is born with an extra X chromosome.
This method is most useful for examining chromosomal translocations, especially ones involving the Y chromosome.
What do the Test Results Mean?
A typical test result will show 46 chromosomes. Two of these 46 chromosomes are sex chromosomes, which determine the sex of the person being tested, and 44 of them are autosomes.
The autosomes are unrelated to determining the sex of the person being tested. Females have two X chromosomes, while males have one X chromosome and one Y chromosome.
Abnormalities that appear in a test sample could be the result of any number of genetic syndromes or conditions. Sometimes, an anomaly will occur in the lab sample that’s not reflected in your body. The karyotype test may be repeated to confirm that there’s an abnormality.
What abnormal results mean?
Abnormal results may be due to a genetic syndrome or condition, such as:
- Down syndrome
- Klinefelter syndrome
- Philadelphia chromosome
