MGMT Methylation Assay: Understand Your Genetic Profile for Informed Health Decisions
What is the MGMT Methylation Test?
The MGMT Methylation Assay is a specialized DNA genetic methylation test that analyzes the methylation status of the MGMT gene promoter. Methylation is a natural biochemical process that acts like a switch, controlling whether a gene is “active” or “silent.” This test provides crucial information about this specific gene’s activity, which is vital for understanding certain cellular pathways and guiding personalized healthcare approaches.
At DNA Labs India, we perform this advanced molecular analysis in our state-of-the-art facility, providing accurate and confidential results to patients and clinicians across India.
Clinical Relevance and Importance
The MGMT gene provides instructions for creating a protein that repairs damaged DNA in cells. The methylation status of this gene’s promoter region can influence its expression. Determining this status through a MGMT Methylation Assay offers valuable insights that may help healthcare providers in assessing and planning management strategies for certain conditions.
Primary Application:
This test is most commonly referenced in oncology for its role in evaluating specific types of tumors. Research indicates that the methylation status of the MGMT promoter can be a significant factor in understanding tumor characteristics and predicting responses to certain therapies. It is a key piece of diagnostic information that aids in creating a more tailored treatment plan.
Why This Information Matters:
Understanding your genetic and epigenetic profile empowers you and your doctor to make more informed decisions. While this test provides critical diagnostic and prognostic information, it is one part of a comprehensive medical evaluation. All results should be reviewed in detail with a qualified healthcare professional who can interpret them in the context of your overall health.
Test Details and Procedure
Sample Required:
The test typically requires a tissue sample from the relevant site, such as a formalin-fixed paraffin-embedded (FFPE) tissue block or slide prepared from a biopsy. Your referring physician will arrange for the appropriate sample to be sent to our lab for analysis.
Methodology:
Our lab uses precise Methylation-Specific PCR technology. This advanced technique can detect even small amounts of methylated DNA, ensuring high sensitivity and specificity for a reliable result.
Reporting Time:
You can expect to receive a clear, comprehensive report within 7 to 10 working days after your sample reaches our laboratory.
Price:
The MGMT Methylation Assay is offered at an exclusive 2026 price of ₹13,000. This reflects our commitment to making advanced genetic testing accessible. Please note that pricing is subject to change in future years.
Why Choose DNA Labs India for Your Genetic Testing?
Patient Privacy: We maintain strict confidentiality protocols, ensuring your genetic information and test results are always secure.
Certified Excellence: We operate a NATA-accredited laboratory and our quality management system is certified against the ISO 9001:2015 standard. You can verify our commitment to quality by viewing our Certificate of Registration.
Advanced Technology: Our lab is equipped with the latest genetic analysis platforms, ensuring the highest accuracy for every test we perform.
Expert Support: Our team includes experienced geneticists and bioinformaticians who analyze your data with rigorous scientific scrutiny.
Nationwide Service: Based in Hyderabad, we offer reliable sample collection and reporting services across India.
Genes Covered in the Test
The DNA Methylation Test from DNA Labs India examines a curated panel of genes critical to methylation and related metabolic pathways. Based on the sample report, here’s a breakdown of the genes included, along with their potential impacts:
| Gene | SNP | Potential Impact | Key Health Implications |
|---|---|---|---|
| BHMT | G742A | Upregulation | May lower homocysteine but could deplete choline, affecting neurotransmitter synthesis and increasing risks for congenital abnormalities. |
| CBS | C699T | Upregulation | Generally protective against elevated homocysteine, with reduced risks for lymphoma and venous diseases, though effects vary by population. |
| GNMT | C1289T | Upregulation | Increases SAM disposal, potentially elevating homocysteine and associating with prostate cancer risks. |
| MAT1A | D18777A | Downregulation | Linked to higher homocysteine and cardiovascular risks, especially with high-fat diets. |
| MTR | A2756G | No Upregulation (Wild Type) | Upregulation in variants can lower homocysteine but may shunt folate, associating with birth defects and cancers. |
| MTRR | A66G | Downregulation | Reduces B-12 recycling, leading to homocysteine elevation and risks for cancers, birth defects, and mood disorders. |
| SHMT1 | C1240T | Downregulation | Favors nucleotide synthesis over methylation, potentially causing genome instability and increasing cancer risks. |
| MTHFR | C677T | No Downregulation (Wild Type) | Downregulation in variants elevates homocysteine, linking to cardiovascular disease, depression, and birth defects. |
| MTHFR | A1298C | Downregulation | May not independently affect homocysteine but compounds risks when combined with other SNPs, associating with infertility and cancers. |
| COMT | V158M | Downregulation | Impairs catecholamine breakdown, potentially increasing risks for mood disorders, breast cancer, and fibromyalgia. |
These genes are analyzed for genotypes, allele frequencies across populations (e.g., South Asian, European), and potential clinical considerations, providing a global perspective on your genetic profile.
Frequently Asked Questions (FAQs)
1. Who should consider taking the MGMT Methylation Assay?
This test is not a general wellness screen. It is prescribed by an oncologist or neurologist based on specific clinical findings and diagnostic needs. Always follow your doctor’s recommendation.
2. How do I get tested?
This test requires a physician’s referral. Please consult your doctor. If the test is deemed necessary, your hospital or clinic will coordinate the sample collection and send it to our lab.
3. What do the results mean?
Your report will indicate the methylation status of the MGMT promoter. A “methylated” status means the gene is often silenced, while an “unmethylated” status suggests it is active. The clinical implication of this result is complex and must be interpreted only by your treating physician in conjunction with other diagnostic findings.
4. Are the results definitive for predicting treatment outcomes?
While this test provides highly valuable predictive information, medicine is not absolute. The result is a strong indicator that helps guide therapy choices but should be considered alongside other clinical and pathological factors.
5. Does DNA Labs India offer other genetic tests?
Yes. We provide a comprehensive portfolio of genetic tests, from ancestry and wellness panels to specialized diagnostic assays like the MGMT Methylation Assay. Explore our complete test directory to learn more.
Take the Next Step in Your Health Journey
Understanding the genetic and epigenetic factors influencing health is a powerful step toward personalized care. The MGMT Methylation Assay offers precise, actionable data for you and your doctor.
To initiate testing, please speak with your healthcare provider. If you are a clinician seeking to order this test for a patient or require more technical information, please contact our client services team in Hyderabad.
DNA Labs India – Delivering Precision, Enabling Confidence.
| Test Name | DNA Genetic Methylation Test |
|---|---|
| Sample type | Blood |
| Test type | Genetic |
| Pre-test Information | The Methylation Panel stands as a groundbreaking test crafted to provide understanding of the pivotal biochemical methylation pathway. Plasma measurement of methylation metabolites and the analysis of genetic single nucleotide polymorphisms (SNPs) via buccal swab form the core of this assessment. Patient outcomes are summarized on a user-friendly Interpretation-at-a-Glance (IAAG) graphic on the front page for swift evaluation of methylation status. Furthermore, the report includes a methylation pathway graphic to offer a lucid comprehension of the underlying biochemistry. |
| Disease | Genetics |
| Method | MLPA |
| Purpose | The Methylation Panel from DNA Labs India integrates both phenotypic and genotypic data into a single profile. It simplifies intricate biochemistry using easily understandable graphics. This comprehensive assessment covers methylation and transsulfuration markers, along with numerous genetic SNPs, offering a thorough evaluation unparalleled in methylation assessment. |
| Preparation | Ambient |
| Fasting | No need |
| Get Reports | 15-20 days |
| Test Price | ₹ 15000 INR |
Note: We offer free home sample collection for online bookings for MGMT Methylation Panel and the test costs a special discounted price of 60000 INR across India. The cities where this service is available include Mumbai, Delhi, Bangalore, Hyderabad, Ahmedabad, Chennai, Kolkata, Surat, Pune, Jaipur, Lucknow, Kanpur, Nagpur, Indore, Thane, Bhopal, Visakhapatnam, Pimpri-Chinchwad, Patna, Vadodara, Ghaziabad, Ludhiana, Agra, Nashik, Faridabad, Meerut, Rajkot, Kalyan-Dombivali, Vasai-Virar, Varanasi, Srinagar, Aurangabad, Dhanbad, Amritsar, Navi Mumbai, Prayagraj, Howrah, Ranchi, Jabalpur, Gwalior, Coimbatore, Vijayawada, Jodhpur, Madurai, Raipur, Kota, Guwahati, Chandigarh, Thiruvananthapuram, Solapur, Hubballi-Dharwad, Tiruchirappalli, Tiruppur, Moradabad, Mysore, Bareily, Gurgaon, Aligarh, Jalandhar, Bhubaneswar, Salem, Mira-Bhayandar, Warangal , Guntur , Bhiwandi, Saharanpur, Gorakhpur, Bikaner, Amravati, Noida, Jamshedpur, Bhilai, Cuttack, Firozabad, Kochi, Nellore , Bhavnagar, Dehradun, Durgapur, Asansol, Rourkela, Nanded, Kolhapur, Ajmer, Akola, Gulbarga, Jamnagar, Ujjain, Loni, Siliguri, Jhansi, Ulhasnagar, Jammu, Sangli-Miraj & Kupwad, Mangalore, Erode10, Belgaum, Ambattur, Tirunelveli, Malegaon, Gaya, Jalgaon, Udaipur, Maheshtala, Davanagere, Kozhikode, Kurnool, Rajpur Sonarpur, Rajahmundry , Bokaro, South Dumdum, Bellary, Patiala, Gopalpur, Agartala, Bhagalpur, Muzaffarnagar, Bhatpara, Panihati, Latur, Dhule, Tirupati , Rohtak, Korba, Bhilwara, Berhampur, Muzaffarpur, Ahmednagar, Mathura, Kollam, Avadi, Kadapa, Kamarhati, Sambalpur, Bilaspur, Shahjahanpur, Satara, Bijapur, Rampur, Shivamogga, Chandrapur, Junagadh, Thrissur, Alwar, Bardhaman, Kulti, Kakinada, Nizamabad, Parbhani, Tumkur, Khammam, Ozhukarai, Bihar Sharif, Panipat, Darbhanga, Bally, Aizawl, Dewas, Ichalkaranji, Karnal, Bathinda, Jalna, Eluru, Kirari Suleman Nagar, Barasat, Purnia, Satna, Mau, Sonipat, Farrukhabad, Sagar, Rourkela, Durg, Imphal, Ratlam, Hapur, Arrah, Karimnagar, Anantapur, Etawah, Ambernath, North Dumdum, Bharatpur, Begusarai, New Delhi, Gandhidham, Baranagar, Tiruvottiyur, Puducherry, Sikar, Thoothukudi, Rewa, Mirzapur, Raichur, Pali, Ramagundam , Haridwar, Vijayanagaram, Katihar, Nagarcoil, Sri Ganganagar, Karawal Nagar, Mango, Thanjavur, Bulandshahr, Uluberia, Murwara, Sambhal, Singrauli, Nadiad, Secunderabad, Naihati, Yamunanagar, Bidhan Nagar, Pallavaram, Bidar, Munger, Panchkula, Burhanpur, Raurkela Industrial Township, Kharagpur, Dindigul, Gandhinagar, Hospet, Nangloi Jat, Malda, Ongole, Deoghar, Chapra, Haldia, Khandwa, Nandyal, Chittoor , Morena, Amroha, Anand, Bhind, Bhalswa Jahangir Pur, Madhyamgram, Bhiwani, Navi Mumbai Panvel Raigad, Baharampur, Ambala, Morvi, Fatehpur, Rae Bareli, Khora, Bhusawal, Orai, Bahraich, Vellore, Mahesana, Sambalpur, Raiganj, Sirsa, Danapur, Serampore, Sultan Pur Majra, Guna, Jaunpur, Panvel, Shivpuri, Surendranagar Dudhrej, Unnao, Hugli and Chinsurah, Alappuzha, Kottayam, Machilipatnam, Shimla, Adoni, Tenali, Proddatur, Saharsa, Hindupur, Sasaram, Hajipur, Bhimavaram, Dehri, Madanapalle, Siwan, Bettiah, Guntakal, Srikakulam, Motihari, Dharmavaram, Gudivada, Narasaraopet, Bagaha, Miryalaguda, Tadipatri, Kishanganj, Karaikudi, Suryapet, Jamalpur, Kavali, Tadepalligudem, Amaravati, Buxar, Jehanabad, Aurangabad.
