DNA Genetic Methylation Testing: Decoding Your Epigenetic Blueprint for Health and Longevity
DNA methylation testing has emerged as a revolutionary tool in personalized medicine, offering insights into how lifestyle, environment, and genetics intersect to influence aging and disease risk. At DNA Labs India, our advanced DNA Genetic Methylation Test (priced at ₹18,000, discounted from ₹25,000) delivers a comprehensive analysis of your epigenetic profile, empowering you to take proactive steps toward optimizing healthspan and longevity. Results are delivered in just 10 days, with free sample collection across India.**
What Does the DNA Genetic Methylation Test Reveal?
Biological Age vs. Chronological Age
Your biological age reflects how well your cells and organs are functioning compared to your calendar age. By analyzing methylation patterns at key genomic sites (such as ASPA, COL1A1, FHL2, LDB2, MIR29B2CHG, SLC12A5, SST, Chr. 16), the test calculates your epigenetic clock – a scientifically validated measure of aging. Accelerated biological age may indicate higher risks for age-related conditions like diabetes, cardiovascular disease, or neurodegenerative disorders.
The relationship between gene methylation levels and aging involves complex regulatory mechanisms affecting various biological processes. Below is an analysis of the listed genes, their functions, and their methylation patterns in aging:
ASPA (Aspartoacylase)
Function:
- Breaks down N-acetyl-L-aspartate (NAA) in the brain, critical for white matter maintenance and myelin sheath integrity.
- Mutations cause Canavan disease, a neurodegenerative disorder.
Methylation in Aging:
- Hypermethylation with age, particularly in CpG islands near its promoter.
- Consequence: Reduced ASPA expression may lead to NAA accumulation, potentially disrupting brain osmotic balance or myelin synthesis.
COL1A1 (Collagen Type I Alpha 1 Chain)
Function:
- Encodes a major component of type I collagen, essential for bone, skin, and connective tissue structure.
Methylation in Aging:
- Promoter hypermethylation correlates with age-related decreased expression.
- Consequence: Reduced collagen production contributes to tissue fragility (e.g., osteoporosis, skin aging).
FHL2 (Four-and-a-Half LIM Domains 2)
Function:
- Acts as a mechanotransducer, linking cellular tension to gene regulation (e.g., proliferation, inflammation).
Methylation in Aging:
- Hypermethylation with age, but paradoxically associated with increased expression.
- Consequence: Elevated FHL2 may drive age-related inflammation and metabolic dysregulation.
LDB2 (LIM Domain Binding 2)
Function:
- Regulates transcription by interacting with LIM-domain proteins.
Methylation in Aging:
- No significant age-related methylation changes reported in studies.
- Consequence: Stable methylation suggests minimal direct role in aging processes.
MIR29B2CHG (Host Gene for miR-29b2/c)
Function:
- Host gene for miR-29b/c, which suppresses cancer progression and regulates extracellular matrix proteins.
Methylation in Aging:
- Hypermethylation in some cancers, but miR-29 expression increases with age.
- Consequence: Age-related miR-29 upregulation drives fibrosis, inflammation, and cellular senescence.
SLC12A5 (Solute Carrier Family 12 Member 5)
Function:
- Encodes KCC2, a potassium-chloride cotransporter critical for neuronal inhibition.
Methylation in Aging:
- Hypermethylation observed in aging, potentially reducing expression.
- Consequence: Impaired synaptic inhibition may contribute to age-related neurological disorders.
SST (Somatostatin)
Function:
- Regulates growth hormone secretion and metabolic processes.
Methylation in Aging:
- Promoter hypermethylation linked to reduced expression in aging brains.
- Consequence: Lower SST levels may disrupt metabolic homeostasis and cognitive function.
Summary of Methylation Patterns
| Gene | Methylation in Aging | Functional Impact |
|---|---|---|
| ASPA | High | NAA accumulation, white matter dysfunction |
| COL1A1 | High | Tissue fragility |
| FHL2 | High | Inflammation, metabolic dysregulation |
| LDB2 | Low | Minimal |
| MIR29B2CHG | Low | miR-29-driven senescence |
| SLC12A5 | High | Neuronal hyperexcitability |
| SST | High | Metabolic/cognitive decline |
These methylation changes reflect both programmed aging processes (e.g., COL1A1, SST) and stochastic/environmental effects (e.g., FHL2, MIR29B2CHG)
Biomarker Quantification
- SAM/SAH Ratio: A low ratio indicates methyl donor deficiency.
- Glutathione Levels: Suboptimal levels impair detoxification.
Personalized Recommendations
- Diet: Tailored plans for methyl-rich foods (leafy greens, eggs) or avoidance of processed meats.
- Supplements: Active folate (5-MTHF), methylcobalamin (B12), or betaine based on genetic variants.
- Lifestyle: Stress-reduction techniques (yoga, meditation) to lower cortisol-induced methylation imbalances.
Why Choose Our DNA Methylation Test?
- Gold-Standard Accuracy: Analyzes 8+ epigenetic markers validated by global research.
- Comprehensive Report: Includes biological age, organ-specific health scores, and personalized lifestyle recommendations.
- CLIA-Certified Labs: Trusted by healthcare professionals worldwide.
- Limited-Time Offer: Save ₹7,000 INR—exclusive discount for early bookings!
How It Works
- Order Your Kit: Delivered to your doorstep.
- Collect Saliva Sample: Simple, non-invasive process.
- Lab Analysis: State-of-the-art methylation sequencing.
- Receive Your Report: Detailed PDF with actionable health insights within 14 days.
Key Features of Your Methylation Report
- Biological vs. Chronological Age: Compare your epigenetic age to your real age.
- Organ-System Analysis: Brain, bone, metabolic, and cancer risk scores.
- Lifestyle Recommendations: Diet, exercise, and stress-management plans tailored to your results.
- Methylation Trends: Visual graphs tracking age-related changes in genes like ASPA, COL1A1, and SST.
Limited-Time Offer: ₹18,000 INR
Act Now—this discount expires soon!
🔹 What’s Included:
- At-home collection kit
- Lab processing & analysis
- 25+ page personalized report
- Free post-test consultation guide
FAQs
Q: How does DNA methylation testing work?
A: It measures chemical changes in DNA (methylation) linked to aging. Hypermethylation in genes like FHL2 or SST accelerates biological aging, while hypomethylation in COL1A1 may indicate tissue fragility.
Q: Is this test accurate?
A: Yes! Our CLIA-certified labs use Illumina sequencing, the gold standard for methylation analysis. Studies show 95% correlation between epigenetic age and health outcomes.
Q: Can I reverse my biological age?
A: Absolutely! Diet, exercise, and stress reduction can lower methylation-based aging scores.
Conclusion: Take Control of Your Epigenetic Destiny
DNA Labs India’s DNA Genetic Methylation Test is more than a diagnostic tool – it’s a roadmap to healthier aging. By understanding your unique epigenetic profile, you can:
- Reverse biological age through targeted interventions.
- Mitigate risks for cancer, dementia, and metabolic disorders.
- Optimize nutrition and lifestyle for longevity.
Act Now: Book your test at ₹18,000 (limited-time offer) and receive results within 10 days. Visit DNA Labs India or call 07941057551 to schedule free sample collection.
For more information about MGMT Methylation Assay, contact DNA Labs India.
| Test Name | DNA Genetic Methylation Test |
|---|---|
| Sample type | Blood |
| Test type | Genetic |
| Pre-test Information | The Methylation Panel stands as a groundbreaking test crafted to provide understanding of the pivotal biochemical methylation pathway. Plasma measurement of methylation metabolites and the analysis of genetic single nucleotide polymorphisms (SNPs) via buccal swab form the core of this assessment. Patient outcomes are summarized on a user-friendly Interpretation-at-a-Glance (IAAG) graphic on the front page for swift evaluation of methylation status. Furthermore, the report includes a methylation pathway graphic to offer a lucid comprehension of the underlying biochemistry. |
| Disease | Genetics |
| Method | MLPA |
| Purpose | The Methylation Panel from DNA Labs India integrates both phenotypic and genotypic data into a single profile. It simplifies intricate biochemistry using easily understandable graphics. This comprehensive assessment covers methylation and transsulfuration markers, along with numerous genetic SNPs, offering a thorough evaluation unparalleled in methylation assessment. |
| Preparation | Ambient |
| Fasting | No need |
| Get Reports | 15-20 days |
| Test Price | ₹ 18000 INR |
Note: We offer free home sample collection for online bookings for MGMT Methylation Panel and the test costs a special discounted price of 60000 INR across India. The cities where this service is available include Mumbai, Delhi, Bangalore, Hyderabad, Ahmedabad, Chennai, Kolkata, Surat, Pune, Jaipur, Lucknow, Kanpur, Nagpur, Indore, Thane, Bhopal, Visakhapatnam, Pimpri-Chinchwad, Patna, Vadodara, Ghaziabad, Ludhiana, Agra, Nashik, Faridabad, Meerut, Rajkot, Kalyan-Dombivali, Vasai-Virar, Varanasi, Srinagar, Aurangabad, Dhanbad, Amritsar, Navi Mumbai, Prayagraj, Howrah, Ranchi, Jabalpur, Gwalior, Coimbatore, Vijayawada, Jodhpur, Madurai, Raipur, Kota, Guwahati, Chandigarh, Thiruvananthapuram, Solapur, Hubballi-Dharwad, Tiruchirappalli, Tiruppur, Moradabad, Mysore, Bareily, Gurgaon, Aligarh, Jalandhar, Bhubaneswar, Salem, Mira-Bhayandar, Warangal , Guntur , Bhiwandi, Saharanpur, Gorakhpur, Bikaner, Amravati, Noida, Jamshedpur, Bhilai, Cuttack, Firozabad, Kochi, Nellore , Bhavnagar, Dehradun, Durgapur, Asansol, Rourkela, Nanded, Kolhapur, Ajmer, Akola, Gulbarga, Jamnagar, Ujjain, Loni, Siliguri, Jhansi, Ulhasnagar, Jammu, Sangli-Miraj & Kupwad, Mangalore, Erode10, Belgaum, Ambattur, Tirunelveli, Malegaon, Gaya, Jalgaon, Udaipur, Maheshtala, Davanagere, Kozhikode, Kurnool, Rajpur Sonarpur, Rajahmundry , Bokaro, South Dumdum, Bellary, Patiala, Gopalpur, Agartala, Bhagalpur, Muzaffarnagar, Bhatpara, Panihati, Latur, Dhule, Tirupati , Rohtak, Korba, Bhilwara, Berhampur, Muzaffarpur, Ahmednagar, Mathura, Kollam, Avadi, Kadapa, Kamarhati, Sambalpur, Bilaspur, Shahjahanpur, Satara, Bijapur, Rampur, Shivamogga, Chandrapur, Junagadh, Thrissur, Alwar, Bardhaman, Kulti, Kakinada, Nizamabad, Parbhani, Tumkur, Khammam, Ozhukarai, Bihar Sharif, Panipat, Darbhanga, Bally, Aizawl, Dewas, Ichalkaranji, Karnal, Bathinda, Jalna, Eluru, Kirari Suleman Nagar, Barasat, Purnia, Satna, Mau, Sonipat, Farrukhabad, Sagar, Rourkela, Durg, Imphal, Ratlam, Hapur, Arrah, Karimnagar, Anantapur, Etawah, Ambernath, North Dumdum, Bharatpur, Begusarai, New Delhi, Gandhidham, Baranagar, Tiruvottiyur, Puducherry, Sikar, Thoothukudi, Rewa, Mirzapur, Raichur, Pali, Ramagundam , Haridwar, Vijayanagaram, Katihar, Nagarcoil, Sri Ganganagar, Karawal Nagar, Mango, Thanjavur, Bulandshahr, Uluberia, Murwara, Sambhal, Singrauli, Nadiad, Secunderabad, Naihati, Yamunanagar, Bidhan Nagar, Pallavaram, Bidar, Munger, Panchkula, Burhanpur, Raurkela Industrial Township, Kharagpur, Dindigul, Gandhinagar, Hospet, Nangloi Jat, Malda, Ongole, Deoghar, Chapra, Haldia, Khandwa, Nandyal, Chittoor , Morena, Amroha, Anand, Bhind, Bhalswa Jahangir Pur, Madhyamgram, Bhiwani, Navi Mumbai Panvel Raigad, Baharampur, Ambala, Morvi, Fatehpur, Rae Bareli, Khora, Bhusawal, Orai, Bahraich, Vellore, Mahesana, Sambalpur, Raiganj, Sirsa, Danapur, Serampore, Sultan Pur Majra, Guna, Jaunpur, Panvel, Shivpuri, Surendranagar Dudhrej, Unnao, Hugli and Chinsurah, Alappuzha, Kottayam, Machilipatnam, Shimla, Adoni, Tenali, Proddatur, Saharsa, Hindupur, Sasaram, Hajipur, Bhimavaram, Dehri, Madanapalle, Siwan, Bettiah, Guntakal, Srikakulam, Motihari, Dharmavaram, Gudivada, Narasaraopet, Bagaha, Miryalaguda, Tadipatri, Kishanganj, Karaikudi, Suryapet, Jamalpur, Kavali, Tadepalligudem, Amaravati, Buxar, Jehanabad, Aurangabad.
