MSH2 Gene Mismatch repair cancer syndrome NGS Genetic Test
Short Name: MSH2 Mismatch Repair Syndrome NGS Test
Also known as: Lynch Syndrome, Hereditary Nonpolyposis Colorectal Cancer
MSH2 Gene Mismatch repair cancer syndrome NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 weeks from sample receipt. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The purpose of this test is to identify mutations in the MSH2 gene that cause mismatch repair cancer syndrome, enabling early cancer risk assessment, personalized screening, and preventive interventions to reduce cancer incidence and improve patient outcomes.
- Test Code
- 2900
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- 3 to 4 weeks from sample receipt
- Fasting Required
- No
- Method
- Next-Generation Sequencing (NGS)
Sample Collection
No special preparation required. Provide detailed clinical history and undergo genetic counseling to understand the test implications.
Method: Venipuncture for blood; other methods for DNA extraction
Laboratory Analysis
A trained phlebotomist will collect a blood sample via venipuncture, or alternative samples like extracted DNA or FTA card blood drops may be used.
Report Delivery
The sample will be labeled, stored appropriately, and transported to the laboratory for NGS analysis.
Timeline: 3 to 4 weeks from sample receipt
Patient Instructions
About This Test
Who Should Get This Test
The purpose of this test is to identify mutations in the MSH2 gene that cause mismatch repair cancer syndrome, enabling early cancer risk assessment, personalized screening, and preventive interventions to reduce cancer incidence and improve patient outcomes.
How to Prepare
- Ensure proper patient identification and consent
- Use sterile collection equipment to avoid contamination
- Label samples accurately with patient details and test information
- Follow standard phlebotomy procedures for blood collection
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"Genetic testing for MSH2 mutations is crucial for individuals with a family history of Lynch syndrome to guide cancer screening and prevention strategies, potentially reducing cancer morbidity and mortality."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed or clotted blood samples
- Insufficient sample volume
- Improper labeling or documentation
- Contaminated or degraded samples
Understanding Your Results
Consult a geneticist or oncologist if you have a family history of cancer, symptoms suggestive of hereditary cancer syndrome, or after receiving test results for personalized management.
Limitations
- ⚠May not detect all types of mutations, such as large deletions or deep intronic variants
- ⚠Results require interpretation by a genetic counselor or healthcare provider
- ⚠Not a standalone diagnostic test for cancer; clinical correlation is necessary
- ⚠Variant of uncertain significance (VUS) may be identified, requiring further analysis
Risks & Considerations
- ●Minimal risk from blood draw, such as bruising or infection
- ●Psychological impact of results, including anxiety or stress
- ●Potential for incidental findings unrelated to MSH2
Interfering Factors
- ●Sample degradation or contamination
- ●Technical errors during sequencing
- ●Insufficient DNA quality or quantity
Compare With Similar Tests
| Test | MSH2 Gene Mismatch repair cancer syndrome NGS Genetic Test | MLH1 Gene Test | BRCA1/2 Gene Test |
|---|---|---|---|
| Comparison | MSH2 Gene Mismatch repair cancer syndrome NGS Genetic Test | Similar NGS test for MLH1 gene mutations in Lynch syndrome; often performed together with MSH2 testing. | Tests for hereditary breast and ovarian cancer; different genetic focus but similar methodology. |
Frequently Asked Questions
What is MSH2 Gene Mismatch Repair Cancer Syndrome?
Who should consider getting this genetic test?
How is the MSH2 Gene NGS Genetic Test performed?
What does a positive test result mean?
What does a negative test result mean?
Is the MSH2 Gene Test covered by insurance in India?
How long does it take to receive the test results?
What are the risks associated with this genetic test?
Can children undergo this genetic test?
How accurate is the NGS genetic test for MSH2 mutations?
What should I do after receiving the test results?
Where can I get the MSH2 Gene Test done in India?
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Reference Laboratory Services
We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
Your Data Privacy
Your medical data is protected under Indian law.
✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.
✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.
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