MSH6 Gene and Colorectal Cancer: Understanding Hereditary Nonpolyposis Type 5
Colorectal cancer is one of the most common types of cancer that affects people worldwide. According to the World Health Organization, it is the third most common cancer in men and the second most common cancer in women. While most cases of colorectal cancer occur sporadically, some cases are hereditary. Hereditary Nonpolyposis Colorectal Cancer (HNPCC) is a hereditary condition that predisposes individuals to develop colorectal cancer at a young age. HNPCC is caused by mutations in several genes, including the MSH6 gene.
The MSH6 Gene and HNPCC
The MSH6 gene is located on chromosome 2 and encodes a protein that is involved in DNA repair. Mutations in the MSH6 gene can result in a loss of function of the protein, leading to errors in DNA repair. These errors can accumulate over time, leading to the development of cancer. HNPCC type 5 is caused by mutations in the MSH6 gene and is characterized by an increased risk of colorectal cancer, as well as other cancers such as endometrial and ovarian cancer.
Symptoms and Diagnosis
The symptoms of colorectal cancer can vary depending on the location and size of the tumor. Some common symptoms include:
- Rectal bleeding
- Abdominal pain
- Changes in bowel habits
- Unexplained weight loss
- Fatigue
Diagnosis of colorectal cancer typically involves a combination of medical history, physical examination, and diagnostic tests such as colonoscopy, biopsy, and imaging studies.
NGS Genetic Test Cost
NGS (Next Generation Sequencing) Genetic Testing is a powerful tool that can be used to identify mutations in the MSH6 gene and other genes associated with hereditary colorectal cancer. This type of testing can be expensive, with costs ranging from INR 20,000 to INR 50,000 depending on the laboratory and the specific tests performed. However, genetic testing can provide valuable information for individuals and families at risk for hereditary colorectal cancer, allowing for earlier detection and treatment.
Conclusion
Hereditary Nonpolyposis Colorectal Cancer (HNPCC) is a hereditary condition that predisposes individuals to develop colorectal cancer at a young age. HNPCC type 5 is caused by mutations in the MSH6 gene and is characterized by an increased risk of colorectal cancer, as well as other cancers such as endometrial and ovarian cancer. While genetic testing for HNPCC can be expensive, it can provide valuable information for individuals and families at risk, allowing for earlier detection and treatment of colorectal cancer.
If you are concerned about your risk for hereditary colorectal cancer, speak with your healthcare provider about genetic testing options.
At DNA Labs India, we offer NGS Genetic Testing for hereditary colorectal cancer and other genetic conditions. Contact us today to learn more about our testing options and costs.
| Test Name | MSH6 Gene Colorectal cancer, hereditary nonpolyposis type 5 NGS Genetic Test |
|---|---|
| Sample type | Blood or Extracted DNA or One drop Blood on FTA Card |
| Test type | Oncologist |
| Pre-test Information | Clinical History of Patient who is going for MSH6 Gene Colorectal cancer, hereditary nonpolyposis type 5 NGS Genetic Test. A Genetic Counselling session to draw a pedigree chart of family members affected with MSH6 Gene Colorectal cancer, hereditary nonpolyposis type 5 NGS Genetic Test gene MSH6 |
| Disease | Cancer |
| Method | NGS Technology |
| Purpose | NULL |
| Preparation | Ambient Room Temperature |
| Fasting | Clinical History of Patient who is going for MSH6 Gene Colorectal cancer, hereditary nonpolyposis type 5 NGS Genetic Test. A Genetic Counselling session to draw a pedigree chart of family members affected with MSH6 Gene Colorectal cancer, hereditary nonpolyposis type 5 NGS Genetic Test gene MSH6 |
| Get Reports | 3 to 4 Weeks |
| Test Price | INR ₹ 20000 |
Note: We offer free home sample collection for online bookings for MSH6 Gene Colorectal cancer, hereditary nonpolyposis type 5 NGS Genetic Test and the test costs a special discounted price of 20000 INR across India. The cities where this service is available include Mumbai, Delhi, Bangalore, Hyderabad, Ahmedabad, Chennai, Kolkata, Surat, Pune, Jaipur, Lucknow, Kanpur, Nagpur, Indore, Thane, Bhopal, Visakhapatnam, Pimpri-Chinchwad, Patna, Vadodara, Ghaziabad, Ludhiana, Agra, Nashik, Faridabad, Meerut, Rajkot, Kalyan-Dombivali, Vasai-Virar, Varanasi, Srinagar, Aurangabad, Dhanbad, Amritsar, Navi Mumbai, Prayagraj, Howrah, Ranchi, Jabalpur, Gwalior, Coimbatore, Vijayawada, Jodhpur, Madurai, Raipur, Kota, Guwahati, Chandigarh, Thiruvananthapuram, Solapur, Hubballi-Dharwad, Tiruchirappalli, Tiruppur, Moradabad, Mysore, Bareily, Gurgaon, Aligarh, Jalandhar, Bhubaneswar, Salem, Mira-Bhayandar, Warangal , Guntur , Bhiwandi, Saharanpur, Gorakhpur, Bikaner, Amravati, Noida, Jamshedpur, Bhilai, Cuttack, Firozabad, Kochi, Nellore , Bhavnagar, Dehradun, Durgapur, Asansol, Rourkela, Nanded, Kolhapur, Ajmer, Akola, Gulbarga, Jamnagar, Ujjain, Loni, Siliguri, Jhansi, Ulhasnagar, Jammu, Sangli-Miraj & Kupwad, Mangalore, Erode10, Belgaum, Ambattur, Tirunelveli, Malegaon, Gaya, Jalgaon, Udaipur, Maheshtala, Davanagere, Kozhikode, Kurnool, Rajpur Sonarpur, Rajahmundry , Bokaro, South Dumdum, Bellary, Patiala, Gopalpur, Agartala, Bhagalpur, Muzaffarnagar, Bhatpara, Panihati, Latur, Dhule, Tirupati , Rohtak, Korba, Bhilwara, Berhampur, Muzaffarpur, Ahmednagar, Mathura, Kollam, Avadi, Kadapa, Kamarhati, Sambalpur, Bilaspur, Shahjahanpur, Satara, Bijapur, Rampur, Shivamogga, Chandrapur, Junagadh, Thrissur, Alwar, Bardhaman, Kulti, Kakinada, Nizamabad, Parbhani, Tumkur, Khammam, Ozhukarai, Bihar Sharif, Panipat, Darbhanga, Bally, Aizawl, Dewas, Ichalkaranji, Karnal, Bathinda, Jalna, Eluru, Kirari Suleman Nagar, Barasat, Purnia, Satna, Mau, Sonipat, Farrukhabad, Sagar, Rourkela, Durg, Imphal, Ratlam, Hapur, Arrah, Karimnagar, Anantapur, Etawah, Ambernath, North Dumdum, Bharatpur, Begusarai, New Delhi, Gandhidham, Baranagar, Tiruvottiyur, Puducherry, Sikar, Thoothukudi, Rewa, Mirzapur, Raichur, Pali, Ramagundam , Haridwar, Vijayanagaram, Katihar, Nagarcoil, Sri Ganganagar, Karawal Nagar, Mango, Thanjavur, Bulandshahr, Uluberia, Murwara, Sambhal, Singrauli, Nadiad, Secunderabad, Naihati, Yamunanagar, Bidhan Nagar, Pallavaram, Bidar, Munger, Panchkula, Burhanpur, Raurkela Industrial Township, Kharagpur, Dindigul, Gandhinagar, Hospet, Nangloi Jat, Malda, Ongole, Deoghar, Chapra, Haldia, Khandwa, Nandyal, Chittoor , Morena, Amroha, Anand, Bhind, Bhalswa Jahangir Pur, Madhyamgram, Bhiwani, Navi Mumbai Panvel Raigad, Baharampur, Ambala, Morvi, Fatehpur, Rae Bareli, Khora, Bhusawal, Orai, Bahraich, Vellore, Mahesana, Sambalpur, Raiganj, Sirsa, Danapur, Serampore, Sultan Pur Majra, Guna, Jaunpur, Panvel, Shivpuri, Surendranagar Dudhrej, Unnao, Hugli and Chinsurah, Alappuzha, Kottayam, Machilipatnam, Shimla, Adoni, Tenali, Proddatur, Saharsa, Hindupur, Sasaram, Hajipur, Bhimavaram, Dehri, Madanapalle, Siwan, Bettiah, Guntakal, Srikakulam, Motihari, Dharmavaram, Gudivada, Narasaraopet, Bagaha, Miryalaguda, Tadipatri, Kishanganj, Karaikudi, Suryapet, Jamalpur, Kavali, Tadepalligudem, Amaravati, Buxar, Jehanabad, Aurangabad.
