MSH6 Gene Colorectal cancer, hereditary nonpolyposis type 5 NGS Genetic Test
Also known as: Lynch Syndrome Type 5, Hereditary Nonpolyposis Colorectal Cancer Type 5, MSH6-Related Hereditary Cancer
MSH6 Gene Colorectal cancer, hereditary nonpolyposis type 5 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 weeks. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
To identify mutations in the MSH6 gene associated with Hereditary Nonpolyposis Colorectal Cancer Type 5 (HNPCC Type 5), enabling early diagnosis, risk assessment, and informed management for individuals and families at hereditary risk of colorectal and related cancers.
- Test Code
- 2851
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- 3 to 4 weeks
- Fasting Required
- No
- Method
- Next Generation Sequencing (NGS)
Sample Collection
A certified phlebotomist visits your home or you visit our nearest center. The process takes under 5 minutes.
Laboratory Analysis
Your sample is analyzed using Next Generation Sequencing (NGS) in our laboratory.
Report Delivery
A certified pathologist reviews and signs your report. You receive it as a secure PDF via email and WhatsApp.
Timeline: 3 to 4 weeks
About This Test
Who Should Get This Test
To identify mutations in the MSH6 gene associated with Hereditary Nonpolyposis Colorectal Cancer Type 5 (HNPCC Type 5), enabling early diagnosis, risk assessment, and informed management for individuals and families at hereditary risk of colorectal and related cancers.
How to Prepare
- For blood sample: Collect in EDTA tube or use FTA card for one drop of blood.
- Ensure proper labeling and handling to avoid contamination.
- Follow standard phlebotomy procedures.
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Understanding Your Results
Positive for pathogenic variant
Confirms diagnosis of HNPCC type 5, indicating increased risk for colorectal, endometrial, ovarian, and other cancers. Recommend enhanced surveillance, genetic counseling for family members, and discussion of risk-reduction strategies.
Negative for pathogenic variant
No pathogenic variants detected in the MSH6 gene. However, this does not eliminate hereditary cancer risk if clinical suspicion remains; consider testing for other HNPCC genes or further evaluation.
Variant of uncertain significance (VUS)
A genetic variant was identified but its clinical significance is unknown. Recommend periodic re-evaluation, family studies, and consultation with a genetic specialist for updated classification.
Consult a healthcare provider if you have a family history of colorectal or related cancers, experience symptoms such as rectal bleeding or abdominal pain, or receive a positive or uncertain genetic test result for guidance on surveillance, prevention, and treatment options.
Frequently Asked Questions
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