Replication Factor C1 Mutation Screening (RFC1 - 80G>A) Test
Short Name: RFC1 Mutation Screening
Also known as: RFC1 Mutation Test, RFC1-80G>A Screening, Replication Factor C1 Gene Test
Replication Factor C1 Mutation Screening (RFC1 - 80G>A) Test test available at DNA Labs India for ₹5,250. Uses End Point PCR + RFLP on Peripheral blood samples. Results in 3-4 days. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
To screen for the RFC1-80G>A mutation to assess the risk of developing breast, ovarian, colorectal, and lung cancer, especially in individuals with a family history.
- Test Code
- 3178
- Price
- ₹5,250
- Sample Type
- Peripheral blood
- Result Time
- 3-4 days
- Fasting Required
- No
- Method
- End Point PCR + RFLP
Sample Collection
A doctor's prescription is required, except for surgery, pregnancy cases, or individuals planning to travel abroad. Prepare a cool pack for sample transport.
Method: Venipuncture
Laboratory Analysis
A blood sample will be drawn from a vein in the arm using standard venipuncture technique.
Report Delivery
Apply pressure to the puncture site with a bandage. Minimal risks include bruising or infection.
Timeline: 3-4 days
Patient Instructions
About This Test
Who Should Get This Test
To screen for the RFC1-80G>A mutation to assess the risk of developing breast, ovarian, colorectal, and lung cancer, especially in individuals with a family history.
How to Prepare
- Use an EDTA Vacutainer (2ml) for sample collection.
- Keep the sample cool with a cool pack during transport.
- Ensure proper labeling and documentation.
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"This test helps identify individuals at higher risk for certain cancers, enabling proactive management and genetic counseling."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed or clotted samples
- Insufficient sample volume
- Improperly labeled samples
Understanding Your Results
Mutation Detected
The RFC1-80G>A mutation is present, indicating an increased risk of certain cancers. Genetic counseling and further screening may be recommended.
No Mutation Detected
The RFC1-80G>A mutation is not detected. However, this does not eliminate cancer risk, and routine screening should continue as advised.
If the test result is positive or if there is a strong family history of cancer, consult a genetic counselor or oncologist for risk management and surveillance plans.
Limitations
- ⚠This test only screens for the RFC1-80G>A mutation and may not detect other genetic variants.
- ⚠Results should be interpreted in conjunction with clinical history and family history.
- ⚠A negative result does not eliminate cancer risk entirely.
Risks & Considerations
- ●Minor bruising or pain at the puncture site
- ●Rare risk of infection
- ●Fainting or dizziness in some individuals
Interfering Factors
- ●Hemolyzed blood sample
- ●Improper sample storage
- ●Contamination during collection
Frequently Asked Questions
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