Clinical Exome Sequencing (CES) is an advanced DNA test that analyzes all clinically relevant coding regions of the genome to identify genetic variations linked to health conditions. Using Next-Generation Sequencing (NGS) technology, CES provides accurate, comprehensive, and cost-effective insights into rare genetic disorders, complex diseases, and pharmacogenomic responses.
What is Clinical Exome Sequencing?
Clinical Exome Sequencing targets the exome, the protein-coding portion of the genome, which makes up about 1% of our DNA but contains up to 85% of disease-causing variants. CES screens all clinically validated genes to detect mutations or variants responsible for genetic conditions, such as:
- Mendelian disorders like Huntington’s disease
- Somatic variants linked to cancers
- Complex conditions like autism and Alzheimer’s disease
- Genetic factors influencing drug response
CES is particularly useful when other genetic tests fail to identify the cause of health or developmental issues.
What is Next-Generation Sequencing (NGS)?
NGS is a high-throughput sequencing technology that allows multiple genes to be sequenced simultaneously, providing faster and more accurate results compared to traditional Sanger sequencing. Advantages of NGS include:
- Comprehensive gene analysis in a single test
- Rapid turnaround time
- Higher accuracy for detecting pathogenic, benign, or variants of unknown significance (VUS)
- Cost-effectiveness compared to whole-genome sequencing
Why Choose Clinical Exome Sequencing?
Unlike whole-genome sequencing, which generates massive amounts of data, CES focuses on clinically relevant genes to provide precise insights at a lower cost. Physicians prefer CES because it:
- Identifies exact variants causing disease
- Reduces unnecessary information unrelated to clinical outcomes
- Supports personalized treatment planning and risk assessment
Cost of Clinical Exome Sequencing in India
The Clinical Exome Sequencing test is priced at ₹20,000.
Turnaround Time: 4–5 weeks
Result Delivery: Securely sent to your email
Privacy and Genetic Data
All genomic data are handled under strict national laboratory and health privacy guidelines. Patients sign a consent form specifying how their genetic information will be stored and used, ensuring confidentiality and compliance with regulations.
Where to Get Clinical Exome Sequencing in India
DNA Labs India is a leading molecular diagnostics provider, offering clinical exome sequencing across 180+ cities in India. Our services include:
- Safe, confidential sample collection
- Home sample collection for convenience
- Expert guidance and counseling for test interpretation
Major City Helplines:
- New Delhi: (011) 40849842
- Mumbai: (022) 48937160
- Kolkata: (033) 40836441
- Chennai: (044) 48137110
- Bangalore: (080) 45684079
- Hyderabad: (040) 49171772
- Ahmedabad: (079) 49107674
Booking: Visit www.dnalabsindia.com to schedule your test online or call your nearest branch.
FAQ – Clinical Exome Sequencing
Q1. What is Clinical Exome Sequencing (CES)?
CES is a DNA test that screens clinically relevant coding regions of the genome to identify disease-causing genetic variants.
Q2. How is CES different from whole-genome sequencing?
CES focuses on clinically validated genes, providing precise insights at lower cost, while whole-genome sequencing generates all genomic data, much of which may not be clinically relevant.
Q3. What conditions can CES detect?
CES can detect Mendelian disorders, somatic mutations linked to cancers, autism, Alzheimer’s, and genetic variations affecting drug response.
Q4. How long does it take to get CES results?
Results are typically available in 4–5 weeks and sent securely via email.
Q5. Is my genetic data safe with DNA Labs India?
Yes, all data are handled according to strict privacy and regulatory guidelines, with consent forms detailing usage and storage.
