What Are BRCA1 and BRCA2 Genes?
BRCA1 and BRCA2 are tumor suppressor genes. Their primary function is to:
- Repair damaged DNA
- Maintain cell stability
- Prevent abnormal cell growth
When harmful mutations occur in these genes, their protective function weakens. This significantly increases the lifetime risk of developing certain cancers.
Key Risk Facts:
- Women with a BRCA1 mutation are more likely to develop breast and ovarian cancer at a younger age.
- BRCA2 mutations increase the risk of breast, ovarian, and prostate cancer.
- If one parent carries a BRCA mutation, each child has a 50% chance of inheriting it.
How Much Does a BRCA Mutation Increase Cancer Risk?
Understanding the difference between general population risk and inherited mutation risk is critical.
Breast Cancer Risk
General population lifetime risk
With BRCA1 mutation (by age 70)
With BRCA2 mutation (by age 70)
Ovarian Cancer Risk
General population lifetime risk
With BRCA1 mutation
With BRCA2 mutation
Note: These statistics clearly show that carrying a BRCA mutation dramatically increases cancer susceptibility compared to individuals without the mutation.
Who Should Consider BRCA1 & BRCA2 Genetic Testing?
You may benefit from BRCA testing if you:
- Have a personal history of breast or ovarian cancer
- Have a strong family history of these cancers
- Have a male relative diagnosed with breast cancer
- Have a known BRCA mutation in the family
- Were diagnosed with cancer at a young age (below 50)
Genetic counseling before and after testing is strongly recommended.
Types of BRCA Genetic Tests Available in India
🔬 BRCA1 & BRCA2 Single Gene Test
Detects pathogenic mutations in BRCA1 and BRCA2
Ideal for individuals with strong family history
Report time: 3-4 weeks
🧬 Extended Breast–Ovarian Cancer Genetic Panel
Includes:
BRCA1, BRCA2, TP53, PTEN, STK11, PALB2, CHEK2, ATM, NBN, BARD1, BRIP1, RAD51C and 30+ additional cancer-associated genes.
Comprehensive hereditary cancer risk assessment
Report time: 3-4 weeks
Free home sample collection is available in major Indian cities.
How Is the BRCA Test Performed?
The test requires a simple:
- Blood sample (EDTA tube)
- OR
- Saliva sample
The sample is analyzed using Next-Generation Sequencing (NGS) technology to detect clinically significant gene variants with high accuracy.
Benefits of BRCA Genetic Testing
Early knowledge empowers proactive healthcare decisions.
BRCA Testing Available Across India
DNA Labs India offers services in:
and 100+ cities nationwide, with convenient home collection.
What Does a BRCA Test Result Mean?
Positive Result
- A pathogenic mutation is detected
- Higher cancer risk
- May require enhanced screening or preventive measures
- Family members should consider testing
Negative Result
- No harmful BRCA mutation detected
- Risk assessment still depends on personal and family history
- Further testing may be advised if suspicion remains high
Frequently Asked Questions (FAQ)
It analyzes tumor suppressor genes BRCA1 and BRCA2 to detect harmful mutations associated with hereditary breast and ovarian cancer.
The BRCA1 & BRCA2 test costs ₹15,000. The extended cancer panel costs ₹20,000. Reports are available in 3-4 weeks.
Yes. Men with BRCA mutations have increased risks of prostate, pancreatic, and male breast cancer.
A blood sample (EDTA tube) or saliva sample is used for testing via NGS technology.
Yes, testing is available across India with home collection services in major and tier-2 cities.
Final Thoughts
Hereditary breast and ovarian cancers can often be managed effectively with early detection and preventive strategies. If you have a family history of cancer, consider discussing BRCA1 and BRCA2 genetic testing in India with your healthcare provider.
Proactive testing today could protect you and future generations.
Book Your Test Today
